The effect of intrauterine growth retardation on renal function in the first two months of life
Background. Children born with growth retardation (GR) have a smaller nephron number and are at increased risk for the development of renal disease and hypertension in adult life. Data on the immediate post-natal development of renal function in neonates born with GR are limited and data on the effe...
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description | Background. Children born with growth retardation (GR) have a smaller nephron number and are at increased risk for the development of renal disease and hypertension in adult life. Data on the immediate post-natal development of renal function in neonates born with GR are limited and data on the effects of aminoglycosides (AGs) on renal function in these infants are lacking. Methods. This was a prospective study of 81 preterm neonates with a mean gestational age of 32.5 weeks, 40 born with GR (small for gestational age, SGA) and 41 without GR (appropriate for gestational age, AGA). The infants were classified into 4 groups. Groups A (n = 21) and B (n = 20) consisted of AGA and SGA neonates, respectively, who received AGs, and groups C (n = 20) and D (n = 20) of AGA and SGA neonates, respectively, who did not receive AG treatment. Indices of renal function were: serum creatinine (SeCr), the fractional excretion of sodium (FENa), potassium (FEK), phosphorus (FEP), magnesium and uric acid (FEUA), the urinary calcium/creatinine ratio and the transtubular potassium gradient (TTKG). Results. No differences were observed in the parameters examined between SGA and AGA neonates who did not receive AGs. Conversely, SGA infants who received AGs after birth (group B) exhibited higher values of SeCr 2 months later. Specifically, their mean ± SD value of SeCr (µmol/l) was 42 ± 05 compared with 33 ± 08 in group D, 35 ± 04 in group A and 33 ± 04 in group C (P < 0.01). These infants also had significantly higher values of TTKG than SGA infants without AG treatment (22 ± 9 vs 13 ± 3 in group D) and FEUA (60 ± 23 vs 35 ± 14 in group D). Their FENa and FEP were also inappropriately high despite having lower serum levels of Na and P. Conclusion. Preterm SGA infants who had no need of AG treatment after birth have similar renal functional maturation than AGA preterm infants at 2 months of life, but preterm SGA infants who received AGs had indications of impaired glomerular and tubular function at this age. |
doi_str_mv | 10.1093/ndt/gfl550 |
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Children born with growth retardation (GR) have a smaller nephron number and are at increased risk for the development of renal disease and hypertension in adult life. Data on the immediate post-natal development of renal function in neonates born with GR are limited and data on the effects of aminoglycosides (AGs) on renal function in these infants are lacking. Methods. This was a prospective study of 81 preterm neonates with a mean gestational age of 32.5 weeks, 40 born with GR (small for gestational age, SGA) and 41 without GR (appropriate for gestational age, AGA). The infants were classified into 4 groups. Groups A (n = 21) and B (n = 20) consisted of AGA and SGA neonates, respectively, who received AGs, and groups C (n = 20) and D (n = 20) of AGA and SGA neonates, respectively, who did not receive AG treatment. Indices of renal function were: serum creatinine (SeCr), the fractional excretion of sodium (FENa), potassium (FEK), phosphorus (FEP), magnesium and uric acid (FEUA), the urinary calcium/creatinine ratio and the transtubular potassium gradient (TTKG). Results. No differences were observed in the parameters examined between SGA and AGA neonates who did not receive AGs. Conversely, SGA infants who received AGs after birth (group B) exhibited higher values of SeCr 2 months later. Specifically, their mean ± SD value of SeCr (µmol/l) was 42 ± 05 compared with 33 ± 08 in group D, 35 ± 04 in group A and 33 ± 04 in group C (P < 0.01). These infants also had significantly higher values of TTKG than SGA infants without AG treatment (22 ± 9 vs 13 ± 3 in group D) and FEUA (60 ± 23 vs 35 ± 14 in group D). Their FENa and FEP were also inappropriately high despite having lower serum levels of Na and P. Conclusion. Preterm SGA infants who had no need of AG treatment after birth have similar renal functional maturation than AGA preterm infants at 2 months of life, but preterm SGA infants who received AGs had indications of impaired glomerular and tubular function at this age.</description><identifier>ISSN: 0931-0509</identifier><identifier>EISSN: 1460-2385</identifier><identifier>DOI: 10.1093/ndt/gfl550</identifier><identifier>PMID: 16998223</identifier><identifier>CODEN: NDTREA</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>aminoglycosides ; Aminoglycosides - metabolism ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Biological and medical sciences ; Calcium - urine ; Creatinine - blood ; Electrolytes ; Emergency and intensive care: renal failure. Dialysis management ; FENa ; Fetal Growth Retardation ; Gestational Age ; Humans ; Intensive care medicine ; Kidney - embryology ; Kidney - growth & development ; Magnesium - urine ; Medical sciences ; Nephrology. Urinary tract diseases ; Nephrons - embryology ; Nephrons - growth & development ; Nephropathies. Renovascular diseases. Renal failure ; Phosphates - urine ; Potassium - metabolism ; Prospective Studies ; Renal failure ; renal function ; small for gestational age ; Sodium - urine ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Surgery of the urinary system ; transtubular potassium gradient (TTKG) ; tubular function ; Uric Acid - metabolism</subject><ispartof>Nephrology, dialysis, transplantation, 2007-01, Vol.22 (1), p.96-103</ispartof><rights>The Author [2006]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org 2006</rights><rights>2007 INIST-CNRS</rights><rights>Copyright Oxford University Press(England) Jan 2007</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c446t-8c4078222f7fea78bca77f2345691219cafed6d021ea6e1b3a48aa3b9897f58d3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1584,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18473745$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16998223$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Giapros, Vasileios</creatorcontrib><creatorcontrib>Papadimitriou, Photeini</creatorcontrib><creatorcontrib>Challa, Anna</creatorcontrib><creatorcontrib>Andronikou, Styliani</creatorcontrib><title>The effect of intrauterine growth retardation on renal function in the first two months of life</title><title>Nephrology, dialysis, transplantation</title><addtitle>Nephrol Dial Transplant</addtitle><description>Background. Children born with growth retardation (GR) have a smaller nephron number and are at increased risk for the development of renal disease and hypertension in adult life. Data on the immediate post-natal development of renal function in neonates born with GR are limited and data on the effects of aminoglycosides (AGs) on renal function in these infants are lacking. Methods. This was a prospective study of 81 preterm neonates with a mean gestational age of 32.5 weeks, 40 born with GR (small for gestational age, SGA) and 41 without GR (appropriate for gestational age, AGA). The infants were classified into 4 groups. Groups A (n = 21) and B (n = 20) consisted of AGA and SGA neonates, respectively, who received AGs, and groups C (n = 20) and D (n = 20) of AGA and SGA neonates, respectively, who did not receive AG treatment. Indices of renal function were: serum creatinine (SeCr), the fractional excretion of sodium (FENa), potassium (FEK), phosphorus (FEP), magnesium and uric acid (FEUA), the urinary calcium/creatinine ratio and the transtubular potassium gradient (TTKG). Results. No differences were observed in the parameters examined between SGA and AGA neonates who did not receive AGs. Conversely, SGA infants who received AGs after birth (group B) exhibited higher values of SeCr 2 months later. Specifically, their mean ± SD value of SeCr (µmol/l) was 42 ± 05 compared with 33 ± 08 in group D, 35 ± 04 in group A and 33 ± 04 in group C (P < 0.01). These infants also had significantly higher values of TTKG than SGA infants without AG treatment (22 ± 9 vs 13 ± 3 in group D) and FEUA (60 ± 23 vs 35 ± 14 in group D). Their FENa and FEP were also inappropriately high despite having lower serum levels of Na and P. Conclusion. Preterm SGA infants who had no need of AG treatment after birth have similar renal functional maturation than AGA preterm infants at 2 months of life, but preterm SGA infants who received AGs had indications of impaired glomerular and tubular function at this age.</description><subject>aminoglycosides</subject><subject>Aminoglycosides - metabolism</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Biological and medical sciences</subject><subject>Calcium - urine</subject><subject>Creatinine - blood</subject><subject>Electrolytes</subject><subject>Emergency and intensive care: renal failure. Dialysis management</subject><subject>FENa</subject><subject>Fetal Growth Retardation</subject><subject>Gestational Age</subject><subject>Humans</subject><subject>Intensive care medicine</subject><subject>Kidney - embryology</subject><subject>Kidney - growth & development</subject><subject>Magnesium - urine</subject><subject>Medical sciences</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Nephrons - embryology</subject><subject>Nephrons - growth & development</subject><subject>Nephropathies. Renovascular diseases. Renal failure</subject><subject>Phosphates - urine</subject><subject>Potassium - metabolism</subject><subject>Prospective Studies</subject><subject>Renal failure</subject><subject>renal function</subject><subject>small for gestational age</subject><subject>Sodium - urine</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Surgery of the urinary system</subject><subject>transtubular potassium gradient (TTKG)</subject><subject>tubular function</subject><subject>Uric Acid - metabolism</subject><issn>0931-0509</issn><issn>1460-2385</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90FtrFDEYBuAgit1Wb_wBEgS9EMbmMJPDpRRtxYIHVizehGzmSzd1NlmTDNV_b-ouLnghBALJw5svL0JPKHlFieancayn134aBnIPLWgvSMe4Gu6jRbukHRmIPkLHpdwQQjST8iE6okJrxRhfILNcAwbvwVWcPA6xZjtXyCECvs7ptq5xhmrzaGtIEbeVIdoJ-zm6Pych4toifMil4nqb8CbFui53YVPw8Ag98HYq8Hi_n6Avb98szy66yw_n785eX3au70XtlOuJbBMxLz1YqVbOSukZ7wehKaPaWQ-jGAmjYAXQFbe9spavtNLSD2rkJ-jFLneb048ZSjWbUBxMk42Q5mKE4nJgWjT47B94k-bcvlQMo4pKwTVt6OUOuZxKyeDNNoeNzb8MJeauc9M6N7vOG366T5xXGxgPdF9yA8_3wBZnJ59tdKEcnOoll_1wcGne_v_BbudCqfDzr7T5uxEtaTAXV9_MR_H-09XnpTBf-W-clKbL</recordid><startdate>20070101</startdate><enddate>20070101</enddate><creator>Giapros, Vasileios</creator><creator>Papadimitriou, Photeini</creator><creator>Challa, Anna</creator><creator>Andronikou, Styliani</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>20070101</creationdate><title>The effect of intrauterine growth retardation on renal function in the first two months of life</title><author>Giapros, Vasileios ; Papadimitriou, Photeini ; Challa, Anna ; Andronikou, Styliani</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c446t-8c4078222f7fea78bca77f2345691219cafed6d021ea6e1b3a48aa3b9897f58d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>aminoglycosides</topic><topic>Aminoglycosides - metabolism</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Biological and medical sciences</topic><topic>Calcium - urine</topic><topic>Creatinine - blood</topic><topic>Electrolytes</topic><topic>Emergency and intensive care: renal failure. Dialysis management</topic><topic>FENa</topic><topic>Fetal Growth Retardation</topic><topic>Gestational Age</topic><topic>Humans</topic><topic>Intensive care medicine</topic><topic>Kidney - embryology</topic><topic>Kidney - growth & development</topic><topic>Magnesium - urine</topic><topic>Medical sciences</topic><topic>Nephrology. Urinary tract diseases</topic><topic>Nephrons - embryology</topic><topic>Nephrons - growth & development</topic><topic>Nephropathies. Renovascular diseases. Renal failure</topic><topic>Phosphates - urine</topic><topic>Potassium - metabolism</topic><topic>Prospective Studies</topic><topic>Renal failure</topic><topic>renal function</topic><topic>small for gestational age</topic><topic>Sodium - urine</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Surgery of the urinary system</topic><topic>transtubular potassium gradient (TTKG)</topic><topic>tubular function</topic><topic>Uric Acid - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Giapros, Vasileios</creatorcontrib><creatorcontrib>Papadimitriou, Photeini</creatorcontrib><creatorcontrib>Challa, Anna</creatorcontrib><creatorcontrib>Andronikou, Styliani</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Nephrology, dialysis, transplantation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Giapros, Vasileios</au><au>Papadimitriou, Photeini</au><au>Challa, Anna</au><au>Andronikou, Styliani</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effect of intrauterine growth retardation on renal function in the first two months of life</atitle><jtitle>Nephrology, dialysis, transplantation</jtitle><addtitle>Nephrol Dial Transplant</addtitle><date>2007-01-01</date><risdate>2007</risdate><volume>22</volume><issue>1</issue><spage>96</spage><epage>103</epage><pages>96-103</pages><issn>0931-0509</issn><eissn>1460-2385</eissn><coden>NDTREA</coden><abstract>Background. Children born with growth retardation (GR) have a smaller nephron number and are at increased risk for the development of renal disease and hypertension in adult life. Data on the immediate post-natal development of renal function in neonates born with GR are limited and data on the effects of aminoglycosides (AGs) on renal function in these infants are lacking. Methods. This was a prospective study of 81 preterm neonates with a mean gestational age of 32.5 weeks, 40 born with GR (small for gestational age, SGA) and 41 without GR (appropriate for gestational age, AGA). The infants were classified into 4 groups. Groups A (n = 21) and B (n = 20) consisted of AGA and SGA neonates, respectively, who received AGs, and groups C (n = 20) and D (n = 20) of AGA and SGA neonates, respectively, who did not receive AG treatment. Indices of renal function were: serum creatinine (SeCr), the fractional excretion of sodium (FENa), potassium (FEK), phosphorus (FEP), magnesium and uric acid (FEUA), the urinary calcium/creatinine ratio and the transtubular potassium gradient (TTKG). Results. No differences were observed in the parameters examined between SGA and AGA neonates who did not receive AGs. Conversely, SGA infants who received AGs after birth (group B) exhibited higher values of SeCr 2 months later. Specifically, their mean ± SD value of SeCr (µmol/l) was 42 ± 05 compared with 33 ± 08 in group D, 35 ± 04 in group A and 33 ± 04 in group C (P < 0.01). These infants also had significantly higher values of TTKG than SGA infants without AG treatment (22 ± 9 vs 13 ± 3 in group D) and FEUA (60 ± 23 vs 35 ± 14 in group D). Their FENa and FEP were also inappropriately high despite having lower serum levels of Na and P. Conclusion. Preterm SGA infants who had no need of AG treatment after birth have similar renal functional maturation than AGA preterm infants at 2 months of life, but preterm SGA infants who received AGs had indications of impaired glomerular and tubular function at this age.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>16998223</pmid><doi>10.1093/ndt/gfl550</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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subjects | aminoglycosides Aminoglycosides - metabolism Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Calcium - urine Creatinine - blood Electrolytes Emergency and intensive care: renal failure. Dialysis management FENa Fetal Growth Retardation Gestational Age Humans Intensive care medicine Kidney - embryology Kidney - growth & development Magnesium - urine Medical sciences Nephrology. Urinary tract diseases Nephrons - embryology Nephrons - growth & development Nephropathies. Renovascular diseases. Renal failure Phosphates - urine Potassium - metabolism Prospective Studies Renal failure renal function small for gestational age Sodium - urine Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the urinary system transtubular potassium gradient (TTKG) tubular function Uric Acid - metabolism |
title | The effect of intrauterine growth retardation on renal function in the first two months of life |
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