Colorectal cancer in a population with endemic Schistosoma mansoni : is this an at-risk population?
Chronic infection with schistosomiasis has been clearly associated with the development of bladder cancer, and infestation is associated with a high incidence of colorectal cancer in endemic populations. Despite this association, the potential role of alterations in tumor suppressor genes colorectal...
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| Veröffentlicht in: | International journal of colorectal disease 2007-02, Vol.22 (2), p.175-181 |
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| container_title | International journal of colorectal disease |
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| creator | MADBOULY, Khaled M SENAGORE, Anthony J MUKERJEE, Abir HUSSIEN, Ahmed M SHEHATA, M. A NAVINE, Philippa DELANEY, Conor P FAZIO, Victor W |
| description | Chronic infection with schistosomiasis has been clearly associated with the development of bladder cancer, and infestation is associated with a high incidence of colorectal cancer in endemic populations. Despite this association, the potential role of alterations in tumor suppressor genes colorectal cancers has never been evaluated in an endemically infected population. The aim of this paper was to compare histopathologic and genetic changes in schistosomal colitis-associated colorectal cancer (SCC) with colorectal cancer in a group of patients from the same population not affected by the disease (NDCC).
Sixty patients were included in this study: SCC-40, NDCC-20. Data collected included age, sex, clinical presentation, presence of synchronous tumors, histopathology, and clinical stage. p53, DCC (deleted in colorectal cancer gene), and mismatch repair genes (MLH1 and MSH2) were studied using immunohistochemical staining.
Patients with SCC were significantly younger than the NDCC group (34.52+/-11.22 years vs 50.73+/-12.75 years, p=0.02). Mucinous adenocarcinoma occurred significantly more frequently in SCC (35 vs 10%, p=0.02). SCC tumors were more frequently stage III or IV, and significantly more synchronous tumors were present in the affected group (SCC-8/40 vs NDCC-1/20, p=0.05). p53 staining was far more frequent in SCC (SCC-32/40 vs NDCC-8/20, p=0.006). DCC expression was similar in two groups. There were only four cases, three in SCC and one in NDCC, that showed microsatellite instability.
The data suggest that schistosomal colitis is more commonly associated with earlier onset of multicentric colorectal cancer, high percentage of mucinous adenocarcinoma, and presents at an advanced stage. The identification of a higher incidence of altered p53 expression in the SCC group raises the possibility of an association between schistosomiasis and alterations in p53 activation as an inciting event in colorectal cancer development. |
| doi_str_mv | 10.1007/s00384-006-0144-3 |
| format | Article |
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Sixty patients were included in this study: SCC-40, NDCC-20. Data collected included age, sex, clinical presentation, presence of synchronous tumors, histopathology, and clinical stage. p53, DCC (deleted in colorectal cancer gene), and mismatch repair genes (MLH1 and MSH2) were studied using immunohistochemical staining.
Patients with SCC were significantly younger than the NDCC group (34.52+/-11.22 years vs 50.73+/-12.75 years, p=0.02). Mucinous adenocarcinoma occurred significantly more frequently in SCC (35 vs 10%, p=0.02). SCC tumors were more frequently stage III or IV, and significantly more synchronous tumors were present in the affected group (SCC-8/40 vs NDCC-1/20, p=0.05). p53 staining was far more frequent in SCC (SCC-32/40 vs NDCC-8/20, p=0.006). DCC expression was similar in two groups. There were only four cases, three in SCC and one in NDCC, that showed microsatellite instability.
The data suggest that schistosomal colitis is more commonly associated with earlier onset of multicentric colorectal cancer, high percentage of mucinous adenocarcinoma, and presents at an advanced stage. The identification of a higher incidence of altered p53 expression in the SCC group raises the possibility of an association between schistosomiasis and alterations in p53 activation as an inciting event in colorectal cancer development.</description><identifier>ISSN: 0179-1958</identifier><identifier>EISSN: 1432-1262</identifier><identifier>DOI: 10.1007/s00384-006-0144-3</identifier><identifier>PMID: 16786317</identifier><identifier>CODEN: IJCDE6</identifier><language>eng</language><publisher>Heidelberg: Springer</publisher><subject>Adenocarcinoma - genetics ; Adenocarcinoma - parasitology ; Adult ; Age of Onset ; Aged ; Biological and medical sciences ; Colitis - parasitology ; Colorectal Neoplasms - genetics ; Colorectal Neoplasms - parasitology ; Colorectal Neoplasms - pathology ; Diseases caused by trematodes ; Egypt ; Endemic Diseases ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; Gene Expression ; Genes, DCC - genetics ; Genes, p53 - genetics ; Helminthic diseases ; Humans ; Infectious diseases ; Male ; Medical sciences ; Middle Aged ; Parasitic diseases ; Schistosomiases ; Schistosomiasis mansoni - complications ; Sex Factors ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Tumors</subject><ispartof>International journal of colorectal disease, 2007-02, Vol.22 (2), p.175-181</ispartof><rights>2007 INIST-CNRS</rights><rights>Springer-Verlag 2007</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-9914572732bd93a030967d5627ca71c7164c586399d7a757f0d52c0612d92d513</citedby><cites>FETCH-LOGICAL-c356t-9914572732bd93a030967d5627ca71c7164c586399d7a757f0d52c0612d92d513</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18507018$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16786317$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MADBOULY, Khaled M</creatorcontrib><creatorcontrib>SENAGORE, Anthony J</creatorcontrib><creatorcontrib>MUKERJEE, Abir</creatorcontrib><creatorcontrib>HUSSIEN, Ahmed M</creatorcontrib><creatorcontrib>SHEHATA, M. A</creatorcontrib><creatorcontrib>NAVINE, Philippa</creatorcontrib><creatorcontrib>DELANEY, Conor P</creatorcontrib><creatorcontrib>FAZIO, Victor W</creatorcontrib><title>Colorectal cancer in a population with endemic Schistosoma mansoni : is this an at-risk population?</title><title>International journal of colorectal disease</title><addtitle>Int J Colorectal Dis</addtitle><description>Chronic infection with schistosomiasis has been clearly associated with the development of bladder cancer, and infestation is associated with a high incidence of colorectal cancer in endemic populations. Despite this association, the potential role of alterations in tumor suppressor genes colorectal cancers has never been evaluated in an endemically infected population. The aim of this paper was to compare histopathologic and genetic changes in schistosomal colitis-associated colorectal cancer (SCC) with colorectal cancer in a group of patients from the same population not affected by the disease (NDCC).
Sixty patients were included in this study: SCC-40, NDCC-20. Data collected included age, sex, clinical presentation, presence of synchronous tumors, histopathology, and clinical stage. p53, DCC (deleted in colorectal cancer gene), and mismatch repair genes (MLH1 and MSH2) were studied using immunohistochemical staining.
Patients with SCC were significantly younger than the NDCC group (34.52+/-11.22 years vs 50.73+/-12.75 years, p=0.02). Mucinous adenocarcinoma occurred significantly more frequently in SCC (35 vs 10%, p=0.02). SCC tumors were more frequently stage III or IV, and significantly more synchronous tumors were present in the affected group (SCC-8/40 vs NDCC-1/20, p=0.05). p53 staining was far more frequent in SCC (SCC-32/40 vs NDCC-8/20, p=0.006). DCC expression was similar in two groups. There were only four cases, three in SCC and one in NDCC, that showed microsatellite instability.
The data suggest that schistosomal colitis is more commonly associated with earlier onset of multicentric colorectal cancer, high percentage of mucinous adenocarcinoma, and presents at an advanced stage. The identification of a higher incidence of altered p53 expression in the SCC group raises the possibility of an association between schistosomiasis and alterations in p53 activation as an inciting event in colorectal cancer development.</description><subject>Adenocarcinoma - genetics</subject><subject>Adenocarcinoma - parasitology</subject><subject>Adult</subject><subject>Age of Onset</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Colitis - parasitology</subject><subject>Colorectal Neoplasms - genetics</subject><subject>Colorectal Neoplasms - parasitology</subject><subject>Colorectal Neoplasms - pathology</subject><subject>Diseases caused by trematodes</subject><subject>Egypt</subject><subject>Endemic Diseases</subject><subject>Female</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Gene Expression</subject><subject>Genes, DCC - genetics</subject><subject>Genes, p53 - genetics</subject><subject>Helminthic diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Parasitic diseases</subject><subject>Schistosomiases</subject><subject>Schistosomiasis mansoni - complications</subject><subject>Sex Factors</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. 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Abdomen</topic><topic>Gene Expression</topic><topic>Genes, DCC - genetics</topic><topic>Genes, p53 - genetics</topic><topic>Helminthic diseases</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Parasitic diseases</topic><topic>Schistosomiases</topic><topic>Schistosomiasis mansoni - complications</topic><topic>Sex Factors</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MADBOULY, Khaled M</creatorcontrib><creatorcontrib>SENAGORE, Anthony J</creatorcontrib><creatorcontrib>MUKERJEE, Abir</creatorcontrib><creatorcontrib>HUSSIEN, Ahmed M</creatorcontrib><creatorcontrib>SHEHATA, M. 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A</au><au>NAVINE, Philippa</au><au>DELANEY, Conor P</au><au>FAZIO, Victor W</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Colorectal cancer in a population with endemic Schistosoma mansoni : is this an at-risk population?</atitle><jtitle>International journal of colorectal disease</jtitle><addtitle>Int J Colorectal Dis</addtitle><date>2007-02-01</date><risdate>2007</risdate><volume>22</volume><issue>2</issue><spage>175</spage><epage>181</epage><pages>175-181</pages><issn>0179-1958</issn><eissn>1432-1262</eissn><coden>IJCDE6</coden><abstract>Chronic infection with schistosomiasis has been clearly associated with the development of bladder cancer, and infestation is associated with a high incidence of colorectal cancer in endemic populations. Despite this association, the potential role of alterations in tumor suppressor genes colorectal cancers has never been evaluated in an endemically infected population. The aim of this paper was to compare histopathologic and genetic changes in schistosomal colitis-associated colorectal cancer (SCC) with colorectal cancer in a group of patients from the same population not affected by the disease (NDCC).
Sixty patients were included in this study: SCC-40, NDCC-20. Data collected included age, sex, clinical presentation, presence of synchronous tumors, histopathology, and clinical stage. p53, DCC (deleted in colorectal cancer gene), and mismatch repair genes (MLH1 and MSH2) were studied using immunohistochemical staining.
Patients with SCC were significantly younger than the NDCC group (34.52+/-11.22 years vs 50.73+/-12.75 years, p=0.02). Mucinous adenocarcinoma occurred significantly more frequently in SCC (35 vs 10%, p=0.02). SCC tumors were more frequently stage III or IV, and significantly more synchronous tumors were present in the affected group (SCC-8/40 vs NDCC-1/20, p=0.05). p53 staining was far more frequent in SCC (SCC-32/40 vs NDCC-8/20, p=0.006). DCC expression was similar in two groups. There were only four cases, three in SCC and one in NDCC, that showed microsatellite instability.
The data suggest that schistosomal colitis is more commonly associated with earlier onset of multicentric colorectal cancer, high percentage of mucinous adenocarcinoma, and presents at an advanced stage. The identification of a higher incidence of altered p53 expression in the SCC group raises the possibility of an association between schistosomiasis and alterations in p53 activation as an inciting event in colorectal cancer development.</abstract><cop>Heidelberg</cop><cop>Berlin</cop><pub>Springer</pub><pmid>16786317</pmid><doi>10.1007/s00384-006-0144-3</doi><tpages>7</tpages></addata></record> |
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| issn | 0179-1958 1432-1262 |
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| subjects | Adenocarcinoma - genetics Adenocarcinoma - parasitology Adult Age of Onset Aged Biological and medical sciences Colitis - parasitology Colorectal Neoplasms - genetics Colorectal Neoplasms - parasitology Colorectal Neoplasms - pathology Diseases caused by trematodes Egypt Endemic Diseases Female Gastroenterology. Liver. Pancreas. Abdomen Gene Expression Genes, DCC - genetics Genes, p53 - genetics Helminthic diseases Humans Infectious diseases Male Medical sciences Middle Aged Parasitic diseases Schistosomiases Schistosomiasis mansoni - complications Sex Factors Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tumors |
| title | Colorectal cancer in a population with endemic Schistosoma mansoni : is this an at-risk population? |
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