Immunogenicity and induction of immunological memory of the heptavalent pneumococcal conjugate vaccine in preterm UK infants
Abstract Data on the immunogenicity and memory induction of pneumococcal conjugate vaccines in very preterm infants is limited. We vaccinated 69 full term and 68 preterm infants (median gestational age (GA) 30 weeks) with a 7-valent pneumococcal conjugate vaccine (PCV7) at 2/3/4 months of age, follo...
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| Veröffentlicht in: | Vaccine 2007-01, Vol.25 (2), p.264-271 |
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| creator | Ruggeberg, Jens U Collins, Clare Clarke, Paul Johnson, Nik Sinha, Ruchi Everest, Neil Chang, John Stanford, Elaine Balmer, Paul Borrow, Ray Martin, Sarah Robinson, Michael J Moxon, E Richard Pollard, Andrew J Heath, Paul T |
| description | Abstract Data on the immunogenicity and memory induction of pneumococcal conjugate vaccines in very preterm infants is limited. We vaccinated 69 full term and 68 preterm infants (median gestational age (GA) 30 weeks) with a 7-valent pneumococcal conjugate vaccine (PCV7) at 2/3/4 months of age, followed by a plain polysaccharide booster at 12 months of age. IgG-GMC (ELISA) was significantly lower in preterm infants to six vaccine serotypes (ST) at 2 months and 5 months of age, to five ST at 12 months of age and to three ST at 13 months of age. A significantly lower proportion of preterm infants achieved IgG levels ≥0.35 μg/ml to ST 4, 6B and 9V at 5 months and to ST 4, 6B, 18C, 19F and 23F at 12 months of age. Fold rises following the polysaccharide booster were comparable to those of term infants. At least 93% of both cohorts achieved IgG ≥0.35 μg/ml to all STs following booster vaccination. Pneumococcal conjugate vaccine at an accelerated schedule of 2/3/4 months of age is likely to provide protection against pneumococcal disease for preterm infants. Antibody concentrations wane over the first year of life in both preterm and term infants and booster vaccination is therefore likely to be important. |
| doi_str_mv | 10.1016/j.vaccine.2006.07.036 |
| format | Article |
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We vaccinated 69 full term and 68 preterm infants (median gestational age (GA) 30 weeks) with a 7-valent pneumococcal conjugate vaccine (PCV7) at 2/3/4 months of age, followed by a plain polysaccharide booster at 12 months of age. IgG-GMC (ELISA) was significantly lower in preterm infants to six vaccine serotypes (ST) at 2 months and 5 months of age, to five ST at 12 months of age and to three ST at 13 months of age. A significantly lower proportion of preterm infants achieved IgG levels ≥0.35 μg/ml to ST 4, 6B and 9V at 5 months and to ST 4, 6B, 18C, 19F and 23F at 12 months of age. Fold rises following the polysaccharide booster were comparable to those of term infants. At least 93% of both cohorts achieved IgG ≥0.35 μg/ml to all STs following booster vaccination. Pneumococcal conjugate vaccine at an accelerated schedule of 2/3/4 months of age is likely to provide protection against pneumococcal disease for preterm infants. Antibody concentrations wane over the first year of life in both preterm and term infants and booster vaccination is therefore likely to be important.</description><identifier>ISSN: 0264-410X</identifier><identifier>EISSN: 1873-2518</identifier><identifier>DOI: 10.1016/j.vaccine.2006.07.036</identifier><identifier>PMID: 17070968</identifier><identifier>CODEN: VACCDE</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Age ; Allergy and Immunology ; Antibodies, Bacterial - blood ; Antigens ; Applied microbiology ; Bacterial Capsules ; Bacteriology ; Biological and medical sciences ; Confidence intervals ; Female ; Fundamental and applied biological sciences. Psychology ; Haemophilus Vaccines - immunology ; Heptavalent Pneumococcal Conjugate Vaccine ; Humans ; Immunogenicity ; Immunologic Memory ; Immunological memory ; Infant ; Infant, Newborn ; Infant, Premature ; Infants ; Male ; Meningococcal Vaccines - immunology ; Microbiology ; Miscellaneous ; Pneumococcal conjugate vaccine ; Pneumococcal Vaccines - immunology ; Polysaccharides, Bacterial - immunology ; Premature birth ; Prematurity ; Streptococcus pneumoniae - immunology ; Vaccination ; Vaccines ; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)</subject><ispartof>Vaccine, 2007-01, Vol.25 (2), p.264-271</ispartof><rights>Elsevier Ltd</rights><rights>2006 Elsevier Ltd</rights><rights>2007 INIST-CNRS</rights><rights>Copyright Elsevier Limited Jan 4, 2007</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c507t-91b04f6ba426b707ad21f969464d4705e51c0716481caee0ef88f782567717593</citedby><cites>FETCH-LOGICAL-c507t-91b04f6ba426b707ad21f969464d4705e51c0716481caee0ef88f782567717593</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1547145692?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,45974,64362,64364,64366,72216</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18422649$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17070968$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ruggeberg, Jens U</creatorcontrib><creatorcontrib>Collins, Clare</creatorcontrib><creatorcontrib>Clarke, Paul</creatorcontrib><creatorcontrib>Johnson, Nik</creatorcontrib><creatorcontrib>Sinha, Ruchi</creatorcontrib><creatorcontrib>Everest, Neil</creatorcontrib><creatorcontrib>Chang, John</creatorcontrib><creatorcontrib>Stanford, Elaine</creatorcontrib><creatorcontrib>Balmer, Paul</creatorcontrib><creatorcontrib>Borrow, Ray</creatorcontrib><creatorcontrib>Martin, Sarah</creatorcontrib><creatorcontrib>Robinson, Michael J</creatorcontrib><creatorcontrib>Moxon, E Richard</creatorcontrib><creatorcontrib>Pollard, Andrew J</creatorcontrib><creatorcontrib>Heath, Paul T</creatorcontrib><title>Immunogenicity and induction of immunological memory of the heptavalent pneumococcal conjugate vaccine in preterm UK infants</title><title>Vaccine</title><addtitle>Vaccine</addtitle><description>Abstract Data on the immunogenicity and memory induction of pneumococcal conjugate vaccines in very preterm infants is limited. We vaccinated 69 full term and 68 preterm infants (median gestational age (GA) 30 weeks) with a 7-valent pneumococcal conjugate vaccine (PCV7) at 2/3/4 months of age, followed by a plain polysaccharide booster at 12 months of age. IgG-GMC (ELISA) was significantly lower in preterm infants to six vaccine serotypes (ST) at 2 months and 5 months of age, to five ST at 12 months of age and to three ST at 13 months of age. A significantly lower proportion of preterm infants achieved IgG levels ≥0.35 μg/ml to ST 4, 6B and 9V at 5 months and to ST 4, 6B, 18C, 19F and 23F at 12 months of age. Fold rises following the polysaccharide booster were comparable to those of term infants. At least 93% of both cohorts achieved IgG ≥0.35 μg/ml to all STs following booster vaccination. Pneumococcal conjugate vaccine at an accelerated schedule of 2/3/4 months of age is likely to provide protection against pneumococcal disease for preterm infants. Antibody concentrations wane over the first year of life in both preterm and term infants and booster vaccination is therefore likely to be important.</description><subject>Age</subject><subject>Allergy and Immunology</subject><subject>Antibodies, Bacterial - blood</subject><subject>Antigens</subject><subject>Applied microbiology</subject><subject>Bacterial Capsules</subject><subject>Bacteriology</subject><subject>Biological and medical sciences</subject><subject>Confidence intervals</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Haemophilus Vaccines - immunology</subject><subject>Heptavalent Pneumococcal Conjugate Vaccine</subject><subject>Humans</subject><subject>Immunogenicity</subject><subject>Immunologic Memory</subject><subject>Immunological memory</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Infant, Premature</subject><subject>Infants</subject><subject>Male</subject><subject>Meningococcal Vaccines - immunology</subject><subject>Microbiology</subject><subject>Miscellaneous</subject><subject>Pneumococcal conjugate vaccine</subject><subject>Pneumococcal Vaccines - immunology</subject><subject>Polysaccharides, Bacterial - immunology</subject><subject>Premature birth</subject><subject>Prematurity</subject><subject>Streptococcus pneumoniae - immunology</subject><subject>Vaccination</subject><subject>Vaccines</subject><subject>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)</subject><issn>0264-410X</issn><issn>1873-2518</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkl-L1DAUxYso7rj6EZSC6FvrTZom7Ysii38WF3zQBd9CJr2dTW2TMUkHBvzwpk5hYF_2KST53cO599wse0mgJED4u6E8KK2NxZIC8BJECRV_lG1II6qC1qR5nG2AclYwAr8usmchDABQV6R9ml0QAQJa3myyv9fTNFu3Q2u0icdc2S43tpt1NM7mrs_N___R7YxWYz7h5PxxeY93mN_hPqqDGtHGfG9xnpx2esG0s8O8UxHz1WTSzPceI_opv_2Wbr2yMTzPnvRqDPhiPS-z28-ffl59LW6-f7m--nhT6BpELFqyBdbzrWKUb5Nz1VHSt7xlnHVMQI010SAIZw3RChGwb5peNLTmQhBRt9Vl9vaku_fuz4whyskEjeOoLLo5SN5UIhU3D4KkZYIDZQl8fQ8c3OxtakKSmgnCat7SRNUnSnsXgsde7r2ZlD9KAnJJUQ5yHZBcUpQgZEox1b1a1efthN25ao0tAW9WQIU0794rq004cw2jKfql8Q8nDtN0Dwa9DNqg1dgZjzrKzpkHrby_p6BHY5dd-I1HDOeuZaAS5I9l5ZaNAw7QAqPVP2d40vo</recordid><startdate>20070104</startdate><enddate>20070104</enddate><creator>Ruggeberg, Jens U</creator><creator>Collins, Clare</creator><creator>Clarke, Paul</creator><creator>Johnson, Nik</creator><creator>Sinha, Ruchi</creator><creator>Everest, Neil</creator><creator>Chang, John</creator><creator>Stanford, Elaine</creator><creator>Balmer, Paul</creator><creator>Borrow, Ray</creator><creator>Martin, Sarah</creator><creator>Robinson, Michael J</creator><creator>Moxon, E Richard</creator><creator>Pollard, Andrew J</creator><creator>Heath, Paul T</creator><general>Elsevier Ltd</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7RV</scope><scope>7T2</scope><scope>7T5</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88C</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0R</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2O</scope><scope>M7N</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20070104</creationdate><title>Immunogenicity and induction of immunological memory of the heptavalent pneumococcal conjugate vaccine in preterm UK infants</title><author>Ruggeberg, Jens U ; Collins, Clare ; Clarke, Paul ; Johnson, Nik ; Sinha, Ruchi ; Everest, Neil ; Chang, John ; Stanford, Elaine ; Balmer, Paul ; Borrow, Ray ; Martin, Sarah ; Robinson, Michael J ; Moxon, E Richard ; Pollard, Andrew J ; Heath, Paul T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c507t-91b04f6ba426b707ad21f969464d4705e51c0716481caee0ef88f782567717593</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Age</topic><topic>Allergy and Immunology</topic><topic>Antibodies, Bacterial - blood</topic><topic>Antigens</topic><topic>Applied microbiology</topic><topic>Bacterial Capsules</topic><topic>Bacteriology</topic><topic>Biological and medical sciences</topic><topic>Confidence intervals</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Haemophilus Vaccines - immunology</topic><topic>Heptavalent Pneumococcal Conjugate Vaccine</topic><topic>Humans</topic><topic>Immunogenicity</topic><topic>Immunologic Memory</topic><topic>Immunological memory</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Infant, Premature</topic><topic>Infants</topic><topic>Male</topic><topic>Meningococcal Vaccines - immunology</topic><topic>Microbiology</topic><topic>Miscellaneous</topic><topic>Pneumococcal conjugate vaccine</topic><topic>Pneumococcal Vaccines - immunology</topic><topic>Polysaccharides, Bacterial - immunology</topic><topic>Premature birth</topic><topic>Prematurity</topic><topic>Streptococcus pneumoniae - immunology</topic><topic>Vaccination</topic><topic>Vaccines</topic><topic>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ruggeberg, Jens U</creatorcontrib><creatorcontrib>Collins, Clare</creatorcontrib><creatorcontrib>Clarke, Paul</creatorcontrib><creatorcontrib>Johnson, Nik</creatorcontrib><creatorcontrib>Sinha, Ruchi</creatorcontrib><creatorcontrib>Everest, Neil</creatorcontrib><creatorcontrib>Chang, John</creatorcontrib><creatorcontrib>Stanford, Elaine</creatorcontrib><creatorcontrib>Balmer, Paul</creatorcontrib><creatorcontrib>Borrow, Ray</creatorcontrib><creatorcontrib>Martin, Sarah</creatorcontrib><creatorcontrib>Robinson, Michael J</creatorcontrib><creatorcontrib>Moxon, E Richard</creatorcontrib><creatorcontrib>Pollard, Andrew J</creatorcontrib><creatorcontrib>Heath, Paul T</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Nursing & Allied Health Database</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Healthcare Administration Database (Alumni)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - 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We vaccinated 69 full term and 68 preterm infants (median gestational age (GA) 30 weeks) with a 7-valent pneumococcal conjugate vaccine (PCV7) at 2/3/4 months of age, followed by a plain polysaccharide booster at 12 months of age. IgG-GMC (ELISA) was significantly lower in preterm infants to six vaccine serotypes (ST) at 2 months and 5 months of age, to five ST at 12 months of age and to three ST at 13 months of age. A significantly lower proportion of preterm infants achieved IgG levels ≥0.35 μg/ml to ST 4, 6B and 9V at 5 months and to ST 4, 6B, 18C, 19F and 23F at 12 months of age. Fold rises following the polysaccharide booster were comparable to those of term infants. At least 93% of both cohorts achieved IgG ≥0.35 μg/ml to all STs following booster vaccination. Pneumococcal conjugate vaccine at an accelerated schedule of 2/3/4 months of age is likely to provide protection against pneumococcal disease for preterm infants. Antibody concentrations wane over the first year of life in both preterm and term infants and booster vaccination is therefore likely to be important.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>17070968</pmid><doi>10.1016/j.vaccine.2006.07.036</doi><tpages>8</tpages></addata></record> |
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| subjects | Age Allergy and Immunology Antibodies, Bacterial - blood Antigens Applied microbiology Bacterial Capsules Bacteriology Biological and medical sciences Confidence intervals Female Fundamental and applied biological sciences. Psychology Haemophilus Vaccines - immunology Heptavalent Pneumococcal Conjugate Vaccine Humans Immunogenicity Immunologic Memory Immunological memory Infant Infant, Newborn Infant, Premature Infants Male Meningococcal Vaccines - immunology Microbiology Miscellaneous Pneumococcal conjugate vaccine Pneumococcal Vaccines - immunology Polysaccharides, Bacterial - immunology Premature birth Prematurity Streptococcus pneumoniae - immunology Vaccination Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) |
| title | Immunogenicity and induction of immunological memory of the heptavalent pneumococcal conjugate vaccine in preterm UK infants |
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