Delphinidin, an Anthocyanidin in Pigmented Fruits and Vegetables, Protects Human HaCaT Keratinocytes and Mouse Skin Against UVB-Mediated Oxidative Stress and Apoptosis
Solar UV radiation, in particular its UVB component, is the primary cause of many adverse biological effects, the most damaging of which is skin cancer. Here, we assessed the photochemopreventive effect of delphinidin, a major anthocyanidin present in many pigmented fruits and vegetables, on UVB-med...
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| Veröffentlicht in: | Journal of investigative dermatology 2007-01, Vol.127 (1), p.222-232 |
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| creator | Afaq, Farrukh Syed, Deeba N. Malik, Arshi Hadi, Naghma Sarfaraz, Sami Kweon, Mee-Hyang Khan, Naghma Zaid, Mohammad Abu Mukhtar, Hasan |
| description | Solar UV radiation, in particular its UVB component, is the primary cause of many adverse biological effects, the most damaging of which is skin cancer. Here, we assessed the photochemopreventive effect of delphinidin, a major anthocyanidin present in many pigmented fruits and vegetables, on UVB-mediated responses in human immortalized HaCaT keratinocytes and SKH-1 hairless mouse skin. We found that pretreatment of cells with delphinidin (1–20μm for 24hours) protected against UVB (15–30mJ/cm2, 24hours)-mediated (i) decrease in cell viability and (ii) induction of apoptosis. Furthermore, we found that pretreatment of HaCaT cells with delphinidin inhibited UVB-mediated (i) increase in lipid peroxidation; (ii) formation of 8-hydroxy-2′-deoxyguanosine (8-OHdG); (iii) decrease in proliferating cell nuclear antigen expression; (iv) increase in poly(ADP-ribose) polymerase cleavage; (v) activation of caspases; (vi) increase in Bax; (vii) decrease in Bcl-2; (viii) upregulation of Bid and Bak; and (ix) downregulation of Bcl-xL. Topical application of delphinidin (1mg/0.1ml DMSO/mouse) to SKH-1 hairless mouse skin inhibited UVB-mediated apoptosis and markers of DNA damage such as cyclobutane pyrimidine dimers and 8-OHdG. Taken together our results suggest that treatment of HaCaT cells and mouse skin with delphinidin inhibited UVB-mediated oxidative stress and reduced DNA damage, thereby protecting the cells from UVB-induced apoptosis. |
| doi_str_mv | 10.1038/sj.jid.5700510 |
| format | Article |
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Here, we assessed the photochemopreventive effect of delphinidin, a major anthocyanidin present in many pigmented fruits and vegetables, on UVB-mediated responses in human immortalized HaCaT keratinocytes and SKH-1 hairless mouse skin. We found that pretreatment of cells with delphinidin (1–20μm for 24hours) protected against UVB (15–30mJ/cm2, 24hours)-mediated (i) decrease in cell viability and (ii) induction of apoptosis. Furthermore, we found that pretreatment of HaCaT cells with delphinidin inhibited UVB-mediated (i) increase in lipid peroxidation; (ii) formation of 8-hydroxy-2′-deoxyguanosine (8-OHdG); (iii) decrease in proliferating cell nuclear antigen expression; (iv) increase in poly(ADP-ribose) polymerase cleavage; (v) activation of caspases; (vi) increase in Bax; (vii) decrease in Bcl-2; (viii) upregulation of Bid and Bak; and (ix) downregulation of Bcl-xL. Topical application of delphinidin (1mg/0.1ml DMSO/mouse) to SKH-1 hairless mouse skin inhibited UVB-mediated apoptosis and markers of DNA damage such as cyclobutane pyrimidine dimers and 8-OHdG. Taken together our results suggest that treatment of HaCaT cells and mouse skin with delphinidin inhibited UVB-mediated oxidative stress and reduced DNA damage, thereby protecting the cells from UVB-induced apoptosis.</description><identifier>ISSN: 0022-202X</identifier><identifier>EISSN: 1523-1747</identifier><identifier>DOI: 10.1038/sj.jid.5700510</identifier><identifier>PMID: 16902416</identifier><identifier>CODEN: JIDEAE</identifier><language>eng</language><publisher>Danvers, MA: Elsevier Inc</publisher><subject>Animals ; Anthocyanins - pharmacology ; Antioxidants - pharmacology ; Apoptosis - drug effects ; Apoptosis - radiation effects ; bcl-2-Associated X Protein - analysis ; Biological and medical sciences ; Caspases - metabolism ; Cell Survival - drug effects ; Cell Survival - radiation effects ; Cells, Cultured ; Deoxyguanosine - analogs & derivatives ; Deoxyguanosine - metabolism ; Dermatology ; Humans ; In Situ Nick-End Labeling ; Keratinocytes - radiation effects ; Lipid Peroxidation - drug effects ; Medical sciences ; Mice ; Mice, Hairless ; Oxidative Stress - drug effects ; Oxidative Stress - radiation effects ; Proliferating Cell Nuclear Antigen - analysis ; Proto-Oncogene Proteins c-bcl-2 - analysis ; Pyrimidine Dimers - metabolism ; Radiation-Protective Agents - pharmacology ; Skin - drug effects ; Skin - radiation effects</subject><ispartof>Journal of investigative dermatology, 2007-01, Vol.127 (1), p.222-232</ispartof><rights>2007 The Society for Investigative Dermatology, Inc</rights><rights>2007 INIST-CNRS</rights><rights>Copyright Nature Publishing Group Jan 2007</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c505t-2396a4461e9cb95095875d970f7fb72c20bf81f2465f8c23653b3fe069c44e853</citedby><cites>FETCH-LOGICAL-c505t-2396a4461e9cb95095875d970f7fb72c20bf81f2465f8c23653b3fe069c44e853</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19046489$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16902416$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Afaq, Farrukh</creatorcontrib><creatorcontrib>Syed, Deeba N.</creatorcontrib><creatorcontrib>Malik, Arshi</creatorcontrib><creatorcontrib>Hadi, Naghma</creatorcontrib><creatorcontrib>Sarfaraz, Sami</creatorcontrib><creatorcontrib>Kweon, Mee-Hyang</creatorcontrib><creatorcontrib>Khan, Naghma</creatorcontrib><creatorcontrib>Zaid, Mohammad Abu</creatorcontrib><creatorcontrib>Mukhtar, Hasan</creatorcontrib><title>Delphinidin, an Anthocyanidin in Pigmented Fruits and Vegetables, Protects Human HaCaT Keratinocytes and Mouse Skin Against UVB-Mediated Oxidative Stress and Apoptosis</title><title>Journal of investigative dermatology</title><addtitle>J Invest Dermatol</addtitle><description>Solar UV radiation, in particular its UVB component, is the primary cause of many adverse biological effects, the most damaging of which is skin cancer. Here, we assessed the photochemopreventive effect of delphinidin, a major anthocyanidin present in many pigmented fruits and vegetables, on UVB-mediated responses in human immortalized HaCaT keratinocytes and SKH-1 hairless mouse skin. We found that pretreatment of cells with delphinidin (1–20μm for 24hours) protected against UVB (15–30mJ/cm2, 24hours)-mediated (i) decrease in cell viability and (ii) induction of apoptosis. Furthermore, we found that pretreatment of HaCaT cells with delphinidin inhibited UVB-mediated (i) increase in lipid peroxidation; (ii) formation of 8-hydroxy-2′-deoxyguanosine (8-OHdG); (iii) decrease in proliferating cell nuclear antigen expression; (iv) increase in poly(ADP-ribose) polymerase cleavage; (v) activation of caspases; (vi) increase in Bax; (vii) decrease in Bcl-2; (viii) upregulation of Bid and Bak; and (ix) downregulation of Bcl-xL. Topical application of delphinidin (1mg/0.1ml DMSO/mouse) to SKH-1 hairless mouse skin inhibited UVB-mediated apoptosis and markers of DNA damage such as cyclobutane pyrimidine dimers and 8-OHdG. Taken together our results suggest that treatment of HaCaT cells and mouse skin with delphinidin inhibited UVB-mediated oxidative stress and reduced DNA damage, thereby protecting the cells from UVB-induced apoptosis.</description><subject>Animals</subject><subject>Anthocyanins - pharmacology</subject><subject>Antioxidants - pharmacology</subject><subject>Apoptosis - drug effects</subject><subject>Apoptosis - radiation effects</subject><subject>bcl-2-Associated X Protein - analysis</subject><subject>Biological and medical sciences</subject><subject>Caspases - metabolism</subject><subject>Cell Survival - drug effects</subject><subject>Cell Survival - radiation effects</subject><subject>Cells, Cultured</subject><subject>Deoxyguanosine - analogs & derivatives</subject><subject>Deoxyguanosine - metabolism</subject><subject>Dermatology</subject><subject>Humans</subject><subject>In Situ Nick-End Labeling</subject><subject>Keratinocytes - radiation effects</subject><subject>Lipid Peroxidation - 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Academic</collection><jtitle>Journal of investigative dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Afaq, Farrukh</au><au>Syed, Deeba N.</au><au>Malik, Arshi</au><au>Hadi, Naghma</au><au>Sarfaraz, Sami</au><au>Kweon, Mee-Hyang</au><au>Khan, Naghma</au><au>Zaid, Mohammad Abu</au><au>Mukhtar, Hasan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Delphinidin, an Anthocyanidin in Pigmented Fruits and Vegetables, Protects Human HaCaT Keratinocytes and Mouse Skin Against UVB-Mediated Oxidative Stress and Apoptosis</atitle><jtitle>Journal of investigative dermatology</jtitle><addtitle>J Invest Dermatol</addtitle><date>2007-01-01</date><risdate>2007</risdate><volume>127</volume><issue>1</issue><spage>222</spage><epage>232</epage><pages>222-232</pages><issn>0022-202X</issn><eissn>1523-1747</eissn><coden>JIDEAE</coden><abstract>Solar UV radiation, in particular its UVB component, is the primary cause of many adverse biological effects, the most damaging of which is skin cancer. Here, we assessed the photochemopreventive effect of delphinidin, a major anthocyanidin present in many pigmented fruits and vegetables, on UVB-mediated responses in human immortalized HaCaT keratinocytes and SKH-1 hairless mouse skin. We found that pretreatment of cells with delphinidin (1–20μm for 24hours) protected against UVB (15–30mJ/cm2, 24hours)-mediated (i) decrease in cell viability and (ii) induction of apoptosis. Furthermore, we found that pretreatment of HaCaT cells with delphinidin inhibited UVB-mediated (i) increase in lipid peroxidation; (ii) formation of 8-hydroxy-2′-deoxyguanosine (8-OHdG); (iii) decrease in proliferating cell nuclear antigen expression; (iv) increase in poly(ADP-ribose) polymerase cleavage; (v) activation of caspases; (vi) increase in Bax; (vii) decrease in Bcl-2; (viii) upregulation of Bid and Bak; and (ix) downregulation of Bcl-xL. Topical application of delphinidin (1mg/0.1ml DMSO/mouse) to SKH-1 hairless mouse skin inhibited UVB-mediated apoptosis and markers of DNA damage such as cyclobutane pyrimidine dimers and 8-OHdG. Taken together our results suggest that treatment of HaCaT cells and mouse skin with delphinidin inhibited UVB-mediated oxidative stress and reduced DNA damage, thereby protecting the cells from UVB-induced apoptosis.</abstract><cop>Danvers, MA</cop><pub>Elsevier Inc</pub><pmid>16902416</pmid><doi>10.1038/sj.jid.5700510</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of investigative dermatology, 2007-01, Vol.127 (1), p.222-232 |
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| subjects | Animals Anthocyanins - pharmacology Antioxidants - pharmacology Apoptosis - drug effects Apoptosis - radiation effects bcl-2-Associated X Protein - analysis Biological and medical sciences Caspases - metabolism Cell Survival - drug effects Cell Survival - radiation effects Cells, Cultured Deoxyguanosine - analogs & derivatives Deoxyguanosine - metabolism Dermatology Humans In Situ Nick-End Labeling Keratinocytes - radiation effects Lipid Peroxidation - drug effects Medical sciences Mice Mice, Hairless Oxidative Stress - drug effects Oxidative Stress - radiation effects Proliferating Cell Nuclear Antigen - analysis Proto-Oncogene Proteins c-bcl-2 - analysis Pyrimidine Dimers - metabolism Radiation-Protective Agents - pharmacology Skin - drug effects Skin - radiation effects |
| title | Delphinidin, an Anthocyanidin in Pigmented Fruits and Vegetables, Protects Human HaCaT Keratinocytes and Mouse Skin Against UVB-Mediated Oxidative Stress and Apoptosis |
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