Causes and pattern of mortality in HIV-infected, hospitalized patients in a tertiary care hospital: a fourteen year study
The introduction of highly active antiRetroviral therapy (HAART) in several centers in India has raised the expectation that many human immunodeficiency virus (HIV)-infected individuals will live longer. However, as most infected individuals remain undiagnosed till the late stage of infection; sever...
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| Veröffentlicht in: | Indian journal of medical sciences 2007-10, Vol.61 (10), p.555-561 |
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| creator | Teja, Vijay Dharma Sudha, Talasila Lakshmi, Vemu |
| description | The introduction of highly active antiRetroviral therapy (HAART) in several centers in India has raised the expectation that many human immunodeficiency virus (HIV)-infected individuals will live longer. However, as most infected individuals remain undiagnosed till the late stage of infection; several continue to succumb to this infection even in the era of HAART.
A retrospective study was conducted over a 14 year period on 2,050 HIV-infected, hospitalized patients to evaluate the pattern of mortality and to determine proportion, risk factors and causes of death.
A total of 145 deaths among HIV-infected patients were documented during hospitalization, with an overall mortality rate of 8.15%: 2.94% in the pre HAART era (1992-1996), 7.29% in the early HAART era (1997-2000) and 9.73% in the present HAART era (2001-2005). 11.7% (17/145) of deceased patients were aware of their HIV-infected status before getting admitted. Only five patients were on any antiretroviral treatment prior to admission. Ninety (62.07%) deaths were HIV-related (AIDS-defining conditions) and 55 (37.93%) were non HIV-related.
Our study stresses the importance of early diagnosis of HIV infection to curb adult mortality, which will continue to rise unless effective treatment interventions are introduced. |
| doi_str_mv | 10.4103/0019-5359.35805 |
| format | Article |
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A retrospective study was conducted over a 14 year period on 2,050 HIV-infected, hospitalized patients to evaluate the pattern of mortality and to determine proportion, risk factors and causes of death.
A total of 145 deaths among HIV-infected patients were documented during hospitalization, with an overall mortality rate of 8.15%: 2.94% in the pre HAART era (1992-1996), 7.29% in the early HAART era (1997-2000) and 9.73% in the present HAART era (2001-2005). 11.7% (17/145) of deceased patients were aware of their HIV-infected status before getting admitted. Only five patients were on any antiretroviral treatment prior to admission. Ninety (62.07%) deaths were HIV-related (AIDS-defining conditions) and 55 (37.93%) were non HIV-related.
Our study stresses the importance of early diagnosis of HIV infection to curb adult mortality, which will continue to rise unless effective treatment interventions are introduced.</description><identifier>ISSN: 0019-5359</identifier><identifier>EISSN: 1998-3654</identifier><identifier>DOI: 10.4103/0019-5359.35805</identifier><identifier>PMID: 17932446</identifier><language>eng</language><publisher>India: Medknow Publications and Media Pvt. Ltd</publisher><subject>Adolescent ; Adult ; AIDS-Related Opportunistic Infections ; Anti-Retroviral Agents - therapeutic use ; Antiretroviral Therapy, Highly Active ; Antiviral agents ; Care and treatment ; CD4 Lymphocyte Count ; Development and progression ; Diagnosis ; Dosage and administration ; Evaluation ; Female ; Health aspects ; Highly active antiretroviral therapy ; HIV infection ; HIV Infections - epidemiology ; HIV Infections - mortality ; HIV Infections - physiopathology ; Hospitalization ; Humans ; India - epidemiology ; Male ; Middle Aged ; Patient outcomes ; Retrospective Studies ; Risk Factors ; Time Factors</subject><ispartof>Indian journal of medical sciences, 2007-10, Vol.61 (10), p.555-561</ispartof><rights>COPYRIGHT 2007 Medknow Publications and Media Pvt. Ltd.</rights><rights>Copyright Medknow Publications Oct 2007</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3835-455936a77940fb030e6a3e3fadc53c2aca47b486de1842193bc5cbba89b8b2f73</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17932446$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Teja, Vijay Dharma</creatorcontrib><creatorcontrib>Sudha, Talasila</creatorcontrib><creatorcontrib>Lakshmi, Vemu</creatorcontrib><title>Causes and pattern of mortality in HIV-infected, hospitalized patients in a tertiary care hospital: a fourteen year study</title><title>Indian journal of medical sciences</title><addtitle>Indian J Med Sci</addtitle><description>The introduction of highly active antiRetroviral therapy (HAART) in several centers in India has raised the expectation that many human immunodeficiency virus (HIV)-infected individuals will live longer. However, as most infected individuals remain undiagnosed till the late stage of infection; several continue to succumb to this infection even in the era of HAART.
A retrospective study was conducted over a 14 year period on 2,050 HIV-infected, hospitalized patients to evaluate the pattern of mortality and to determine proportion, risk factors and causes of death.
A total of 145 deaths among HIV-infected patients were documented during hospitalization, with an overall mortality rate of 8.15%: 2.94% in the pre HAART era (1992-1996), 7.29% in the early HAART era (1997-2000) and 9.73% in the present HAART era (2001-2005). 11.7% (17/145) of deceased patients were aware of their HIV-infected status before getting admitted. Only five patients were on any antiretroviral treatment prior to admission. Ninety (62.07%) deaths were HIV-related (AIDS-defining conditions) and 55 (37.93%) were non HIV-related.
Our study stresses the importance of early diagnosis of HIV infection to curb adult mortality, which will continue to rise unless effective treatment interventions are introduced.</description><subject>Adolescent</subject><subject>Adult</subject><subject>AIDS-Related Opportunistic Infections</subject><subject>Anti-Retroviral Agents - therapeutic use</subject><subject>Antiretroviral Therapy, Highly Active</subject><subject>Antiviral agents</subject><subject>Care and treatment</subject><subject>CD4 Lymphocyte Count</subject><subject>Development and progression</subject><subject>Diagnosis</subject><subject>Dosage and administration</subject><subject>Evaluation</subject><subject>Female</subject><subject>Health aspects</subject><subject>Highly active antiretroviral therapy</subject><subject>HIV infection</subject><subject>HIV Infections - epidemiology</subject><subject>HIV Infections - mortality</subject><subject>HIV Infections - physiopathology</subject><subject>Hospitalization</subject><subject>Humans</subject><subject>India - epidemiology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Patient outcomes</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Time Factors</subject><issn>0019-5359</issn><issn>1998-3654</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNptkkFv1DAQhS0EotvCmRuyQOJEtnZsJzG3akVppUpcgKs1cSbFVeIstnMIvx6nuyoCrSzL0sz3nsYzQ8gbzraSM3HJGNeFEkpvhWqYekY2XOumEJWSz8nmKXtGzmN8YKwUpWIvyRmvtSilrDZk2cEcMVLwHd1DShg8nXo6TiHB4NJCnac3tz8K53u0CbuP9OcU925N_sZHiUOf4ooBzerkICzUQsAn8FPO9NMcEqKnC0KgMc3d8oq86GGI-Pr4XpDv15-_7W6Ku69fbndXd4UVjVCFVEqLCupaS9a3TDCsQKDoobNK2BIsyLqVTdUhb2TJtWitsm0LjW6btuxrcUE-HHz3Yfo1Y0xmdNHiMIDHaY6makRdNpxn8N1_4EOu2ufaDNdKyXxXt_cH6B4GNLkrUwpgV0dzxWvGmK6VylRxgrpHjwGGyWPvcvgffnuCz6fD0dmTgsuDwIYpxoC92Qc35tYbzsy6GWadvVlnbx43IyveHn83tyN2f_njKog_iUux0Q</recordid><startdate>20071001</startdate><enddate>20071001</enddate><creator>Teja, Vijay Dharma</creator><creator>Sudha, Talasila</creator><creator>Lakshmi, Vemu</creator><general>Medknow Publications and Media Pvt. 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therapeutic use</topic><topic>Antiretroviral Therapy, Highly Active</topic><topic>Antiviral agents</topic><topic>Care and treatment</topic><topic>CD4 Lymphocyte Count</topic><topic>Development and progression</topic><topic>Diagnosis</topic><topic>Dosage and administration</topic><topic>Evaluation</topic><topic>Female</topic><topic>Health aspects</topic><topic>Highly active antiretroviral therapy</topic><topic>HIV infection</topic><topic>HIV Infections - epidemiology</topic><topic>HIV Infections - mortality</topic><topic>HIV Infections - physiopathology</topic><topic>Hospitalization</topic><topic>Humans</topic><topic>India - epidemiology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Patient outcomes</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Time Factors</topic><toplevel>online_resources</toplevel><creatorcontrib>Teja, Vijay Dharma</creatorcontrib><creatorcontrib>Sudha, Talasila</creatorcontrib><creatorcontrib>Lakshmi, Vemu</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Indian journal of medical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Teja, Vijay Dharma</au><au>Sudha, Talasila</au><au>Lakshmi, Vemu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Causes and pattern of mortality in HIV-infected, hospitalized patients in a tertiary care hospital: a fourteen year study</atitle><jtitle>Indian journal of medical sciences</jtitle><addtitle>Indian J Med Sci</addtitle><date>2007-10-01</date><risdate>2007</risdate><volume>61</volume><issue>10</issue><spage>555</spage><epage>561</epage><pages>555-561</pages><issn>0019-5359</issn><eissn>1998-3654</eissn><abstract>The introduction of highly active antiRetroviral therapy (HAART) in several centers in India has raised the expectation that many human immunodeficiency virus (HIV)-infected individuals will live longer. However, as most infected individuals remain undiagnosed till the late stage of infection; several continue to succumb to this infection even in the era of HAART.
A retrospective study was conducted over a 14 year period on 2,050 HIV-infected, hospitalized patients to evaluate the pattern of mortality and to determine proportion, risk factors and causes of death.
A total of 145 deaths among HIV-infected patients were documented during hospitalization, with an overall mortality rate of 8.15%: 2.94% in the pre HAART era (1992-1996), 7.29% in the early HAART era (1997-2000) and 9.73% in the present HAART era (2001-2005). 11.7% (17/145) of deceased patients were aware of their HIV-infected status before getting admitted. Only five patients were on any antiretroviral treatment prior to admission. Ninety (62.07%) deaths were HIV-related (AIDS-defining conditions) and 55 (37.93%) were non HIV-related.
Our study stresses the importance of early diagnosis of HIV infection to curb adult mortality, which will continue to rise unless effective treatment interventions are introduced.</abstract><cop>India</cop><pub>Medknow Publications and Media Pvt. Ltd</pub><pmid>17932446</pmid><doi>10.4103/0019-5359.35805</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Indian journal of medical sciences, 2007-10, Vol.61 (10), p.555-561 |
| issn | 0019-5359 1998-3654 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Bioline International |
| subjects | Adolescent Adult AIDS-Related Opportunistic Infections Anti-Retroviral Agents - therapeutic use Antiretroviral Therapy, Highly Active Antiviral agents Care and treatment CD4 Lymphocyte Count Development and progression Diagnosis Dosage and administration Evaluation Female Health aspects Highly active antiretroviral therapy HIV infection HIV Infections - epidemiology HIV Infections - mortality HIV Infections - physiopathology Hospitalization Humans India - epidemiology Male Middle Aged Patient outcomes Retrospective Studies Risk Factors Time Factors |
| title | Causes and pattern of mortality in HIV-infected, hospitalized patients in a tertiary care hospital: a fourteen year study |
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