Modulation of cholestasis-induced antinociception in rats by two NMDA receptor antagonists: MK-801 and magnesium sulfate

Acute cholestasis is associated with increased activity of the endogenous opioid system that results to changes including analgesia. N-methyl- d-aspartate (NMDA) receptors are involved in the nociceptive pathway and play a major role in the development of morphine induced analgesia. The magnesium ac...

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Veröffentlicht in:	European journal of pharmacology 2007-01, Vol.554 (2), p.123-127
Hauptverfasser:	Hasanein, Parisa, Parviz, Mohsen, Keshavarz, Mansoor, Javanmardi, Kazem, Allahtavakoli, Mohammad, Ghaseminejad, Majid
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance Animals Antinociception Bile Ducts - surgery Biological and medical sciences Cholestasis Cholestasis - etiology Cholestasis - physiopathology Dizocilpine Maleate - administration & dosage Dizocilpine Maleate - pharmacology Excitatory Amino Acid Antagonists - administration & dosage Excitatory Amino Acid Antagonists - pharmacology Gastroenterology. Liver. Pancreas. Abdomen Ligation - adverse effects Liver. Biliary tract. Portal circulation. Exocrine pancreas Magnesium Magnesium - administration & dosage Magnesium - pharmacology Medical sciences Mk-801 Other diseases. Semiology Pain - etiology Pain - physiopathology Pain - prevention & control Pain Measurement - methods Pharmacology. Drug treatments Rat Rats Rats, Sprague-Dawley Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors Receptors, N-Methyl-D-Aspartate - physiology
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