A naturally occurring genetic variant of human XRCC2 (R188H) confers increased resistance to cisplatin-induced DNA damage

Homologous recombination, a major double strand break repair pathway, plays critical roles in maintaining genome stability. Genetic polymorphisms in HR genes have been implicated in cancer risk. We report a novel assay system for evaluating polymorphisms in human homologous recombination genes using...

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Veröffentlicht in:	Biochemical and biophysical research communications 2007-01, Vol.352 (3), p.763-768
Hauptverfasser:	Danoy, Patrick, Sonoda, Eiichiro, Lathrop, Mark, Takeda, Shunichi, Matsuda, Fumihiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals B-Lymphocytes - drug effects B-Lymphocytes - physiology Cancer risk Cell Line Chickens Cisplatin Cisplatin - administration & dosage DNA Damage - physiology DNA repair gene DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism DT40 Homologous recombination Humans Mutation RAD51 Rad51 Recombinase - metabolism Single nucleotide polymorphism XRCC2 XRCC3
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