Durable HIV-1 antibody and T-cell responses elicited by an adjuvanted multi-protein recombinant vaccine in uninfected human volunteers

Abstract Background Use of the recombinant proteins NefTat and gp120W61D formulated with the AS02A adjuvant system was previously shown to protect against AIDS in a rhesus macaque SHIV animal model system. Methods Eighty-four HIV uninfected human participants were vaccinated intramuscularly at 0, 1,...

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Veröffentlicht in:	Vaccine 2007-01, Vol.25 (3), p.510-518
Hauptverfasser:	Goepfert, Paul A, Tomaras, Georgia D, Horton, Helen, Montefiori, David, Ferrari, Guido, Deers, Mark, Voss, Gerald, Koutsoukos, Marguerite, Pedneault, Louise, Vandepapeliere, Pierre, McElrath, M. Juliana, Spearman, Paul, Fuchs, Jonathan D, Koblin, Beryl A, Blattner, William A, Frey, Sharon, Baden, Lindsey R, Harro, Clayton, Evans, Thomas
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired immune deficiency syndrome Adjuvants, Immunologic - pharmacology Adolescent Adult AIDS AIDS Vaccines - immunology Allergy and Immunology Animal models Antibody Formation - immunology Applied microbiology AS02A adjuvant Biological and medical sciences CD8-Positive T-Lymphocytes - immunology Cell Proliferation Clinical trial Double-Blind Method Enzyme-Linked Immunosorbent Assay Female Fundamental and applied biological sciences. Psychology gp120 HIV HIV Antibodies - adverse effects HIV Antibodies - biosynthesis HIV Envelope Protein gp120 - immunology HIV vaccine HIV-1 - immunology Human immunodeficiency virus Human immunodeficiency virus 1 Humans Immunity, Cellular - immunology Immunization Infections Interferon-gamma - analysis Lymphocytes Macaca mulatta Malaria Vaccines - pharmacology Male Microbiology Middle Aged Miscellaneous Nef Neutralization Tests Pathogenesis Proteins Response rates T-Lymphocytes - immunology Tat Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Vaccines, Synthetic - immunology Virology
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