Preparation of secolycorines against acetylcholinesterase

Secolycorines were facilely prepared from lycorine and some of them are more potent than galanthamine against acetylcholinesterase. 5,6-Secolycorines possessing a 5,6-dihydrophenanthridine skeleton were facilely prepared from lycorine through chemical transformations, mainly including N-alkylation,...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2007-01, Vol.15 (2), p.1034-1043
Hauptverfasser:	Lee, Shoei-Sheng, Venkatesham, Uppala, Rao, Chitneni Prasad, Lam, Sio-Hong, Lin, Jung-Hsin
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholinesterase - metabolism Alkylation Animals Anti-acetylcholinesterase Chemical modification Chemical Phenomena Chemistry, Physical Cholinesterase Inhibitors - chemical synthesis Cholinesterase Inhibitors - pharmacology Chromatography, Thin Layer Crinum - chemistry Dose-Response Relationship, Drug Drug Design Eels Galantamine - pharmacology Indicators and Reagents Lycorine Magnetic Resonance Spectroscopy Mass Spectrometry Phenanthridines - chemical synthesis Phenanthridines - pharmacology Secolycorines Spectroscopy, Fourier Transform Infrared Stereoisomerism
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