Raman spectroscopy of coated pharmaceutical tablets and physical models for multivariate calibration to tablet coating thickness

Raman spectra of a set of coated pharmaceutical tablets were analyzed for the purpose of calibrating the spectra to tablet coating thickness. Acetaminophen tablets were coated with a hydroxypropylmethylcellulose/polyethylene glycol film coating whose thickness was varied from 0 to 6% weight gain. Co...

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Veröffentlicht in:	Journal of pharmaceutical and biomedical analysis 2007-01, Vol.43 (1), p.39-48
Hauptverfasser:	Kauffman, John F., Dellibovi, Marybeth, Cunningham, Charles R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetaminophen - administration & dosage Acetaminophen - analysis Algorithms Analgesics, Non-Narcotic - administration & dosage Analgesics, Non-Narcotic - analysis Analysis Analytical, structural and metabolic biochemistry Biological and medical sciences Calibration Chemometrics Coloring Agents Data Interpretation, Statistical Excipients Fluorescent Dyes Fundamental and applied biological sciences. Psychology General pharmacology Hypromellose Derivatives Indicators and Reagents Medical sciences Methylcellulose - analogs & derivatives Models, Chemical Multivariate calibration Pharmacology. Drug treatments Photobleaching Polyethylene Glycols Raman spectroscopy Spectrum Analysis, Raman Tablet coating analysis Tablets - analysis Target factor analysis Titanium
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