Angelan isolated from Angelica gigas Nakai induces dendritic cell maturation through toll-like receptor 4
During the evolution of neoplastic diseases, dendritic cell (DC) functions are usually attenuated, and this presents a problem to DC-based immunotherapies against cancer. Here, we investigated the effects of angelan, an acidic polysaccharide isolated from Angelica gigas Nakai, on DC maturation. Ange...
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| Veröffentlicht in: | International immunopharmacology 2007-01, Vol.7 (1), p.78-87 |
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| creator | Kim, Jee Youn Yoon, Yeo Dae Ahn, Ji Mi Kang, Jong Soon Park, Song-Kyu Lee, Kiho Song, Kyung Bin Kim, Hwan Mook Han, Sang-Bae |
| description | During the evolution of neoplastic diseases, dendritic cell (DC) functions are usually attenuated, and this presents a problem to DC-based immunotherapies against cancer. Here, we investigated the effects of angelan, an acidic polysaccharide isolated from Angelica gigas Nakai, on DC maturation. Angelan efficiently increased the maturation of tlr4+/+ DCs from C57BL/6 and C3H/HeN mice, but not tlr4−/− DCs from C3H/HeJ mice. Phenotypic maturation was confirmed by the elevated expressions of CD80, CD86, and MHC-class II molecules, and functional maturation by increased IL-12 production, enhanced allogenic T cell stimulation, and decreased endocytosis. Angelan was found to activate ERK and NF-κB, which are signaling molecules down-stream of toll-like receptor-4 (TLR4) receptors. Angelan-treated mature DC more effectively inhibited B16F10 tumor growth than immature DCs in syngenic murine tumor model. These results indicate that angelan induces DC maturation via TLR4 signaling pathways and suggest the possible use of angelan in DC-based immunotherapies. |
| doi_str_mv | 10.1016/j.intimp.2006.08.017 |
| format | Article |
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Here, we investigated the effects of angelan, an acidic polysaccharide isolated from Angelica gigas Nakai, on DC maturation. Angelan efficiently increased the maturation of tlr4+/+ DCs from C57BL/6 and C3H/HeN mice, but not tlr4−/− DCs from C3H/HeJ mice. Phenotypic maturation was confirmed by the elevated expressions of CD80, CD86, and MHC-class II molecules, and functional maturation by increased IL-12 production, enhanced allogenic T cell stimulation, and decreased endocytosis. Angelan was found to activate ERK and NF-κB, which are signaling molecules down-stream of toll-like receptor-4 (TLR4) receptors. Angelan-treated mature DC more effectively inhibited B16F10 tumor growth than immature DCs in syngenic murine tumor model. These results indicate that angelan induces DC maturation via TLR4 signaling pathways and suggest the possible use of angelan in DC-based immunotherapies.</description><identifier>ISSN: 1567-5769</identifier><identifier>EISSN: 1878-1705</identifier><identifier>DOI: 10.1016/j.intimp.2006.08.017</identifier><identifier>PMID: 17161820</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Angelan ; Angelica ; Angelica - chemistry ; Angelica gigas Nakai ; Animals ; Biological and medical sciences ; Cell Differentiation - drug effects ; Cells, Cultured ; Cytokines - immunology ; Dendritic cells ; Dendritic Cells - cytology ; Dendritic Cells - drug effects ; Dendritic Cells - immunology ; Endocytosis - drug effects ; Female ; Lymphocyte Culture Test, Mixed ; Medical sciences ; Melanoma, Experimental - drug therapy ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C3H ; Mice, Inbred C57BL ; Pharmacology. Drug treatments ; Polysaccharides ; Polysaccharides - isolation & purification ; Polysaccharides - pharmacology ; Spleen - cytology ; T-Lymphocytes - immunology ; Toll-like receptor 4 ; Toll-Like Receptor 4 - immunology ; Xenograft Model Antitumor Assays</subject><ispartof>International immunopharmacology, 2007-01, Vol.7 (1), p.78-87</ispartof><rights>2006 Elsevier B.V.</rights><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c487t-ea2d68f847459c533cbdb9b2483a99866394b006296565cd3f19f4c3d965864d3</citedby><cites>FETCH-LOGICAL-c487t-ea2d68f847459c533cbdb9b2483a99866394b006296565cd3f19f4c3d965864d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.intimp.2006.08.017$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,4022,27921,27922,27923,45993</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18403228$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17161820$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Jee Youn</creatorcontrib><creatorcontrib>Yoon, Yeo Dae</creatorcontrib><creatorcontrib>Ahn, Ji Mi</creatorcontrib><creatorcontrib>Kang, Jong Soon</creatorcontrib><creatorcontrib>Park, Song-Kyu</creatorcontrib><creatorcontrib>Lee, Kiho</creatorcontrib><creatorcontrib>Song, Kyung Bin</creatorcontrib><creatorcontrib>Kim, Hwan Mook</creatorcontrib><creatorcontrib>Han, Sang-Bae</creatorcontrib><title>Angelan isolated from Angelica gigas Nakai induces dendritic cell maturation through toll-like receptor 4</title><title>International immunopharmacology</title><addtitle>Int Immunopharmacol</addtitle><description>During the evolution of neoplastic diseases, dendritic cell (DC) functions are usually attenuated, and this presents a problem to DC-based immunotherapies against cancer. Here, we investigated the effects of angelan, an acidic polysaccharide isolated from Angelica gigas Nakai, on DC maturation. Angelan efficiently increased the maturation of tlr4+/+ DCs from C57BL/6 and C3H/HeN mice, but not tlr4−/− DCs from C3H/HeJ mice. Phenotypic maturation was confirmed by the elevated expressions of CD80, CD86, and MHC-class II molecules, and functional maturation by increased IL-12 production, enhanced allogenic T cell stimulation, and decreased endocytosis. Angelan was found to activate ERK and NF-κB, which are signaling molecules down-stream of toll-like receptor-4 (TLR4) receptors. Angelan-treated mature DC more effectively inhibited B16F10 tumor growth than immature DCs in syngenic murine tumor model. These results indicate that angelan induces DC maturation via TLR4 signaling pathways and suggest the possible use of angelan in DC-based immunotherapies.</description><subject>Angelan</subject><subject>Angelica</subject><subject>Angelica - chemistry</subject><subject>Angelica gigas Nakai</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cell Differentiation - drug effects</subject><subject>Cells, Cultured</subject><subject>Cytokines - immunology</subject><subject>Dendritic cells</subject><subject>Dendritic Cells - cytology</subject><subject>Dendritic Cells - drug effects</subject><subject>Dendritic Cells - immunology</subject><subject>Endocytosis - drug effects</subject><subject>Female</subject><subject>Lymphocyte Culture Test, Mixed</subject><subject>Medical sciences</subject><subject>Melanoma, Experimental - drug therapy</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Mice, Inbred C3H</subject><subject>Mice, Inbred C57BL</subject><subject>Pharmacology. Drug treatments</subject><subject>Polysaccharides</subject><subject>Polysaccharides - isolation & purification</subject><subject>Polysaccharides - pharmacology</subject><subject>Spleen - cytology</subject><subject>T-Lymphocytes - immunology</subject><subject>Toll-like receptor 4</subject><subject>Toll-Like Receptor 4 - immunology</subject><subject>Xenograft Model Antitumor Assays</subject><issn>1567-5769</issn><issn>1878-1705</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1v1DAQhiMEoqXwDxDyBW4JdvwR-4JUVXxJFVzgbDm2s52tYy-2U4l_j5ddqTc4zYeeGc28b9e9JnggmIj3-wFihfUwjBiLAcsBk-lJd0nkJHsyYf605VxMPZ-EuuhelLLHjcCMPO8uyEQEkSO-7OA67nwwEUFJwVTv0JLTiv52wRq0g50p6Ju5N4Agus36gpyPLkMFi6wPAa2mbtlUSBHVu5y23R2qKYQ-wL1H2Vt_qCkj9rJ7tphQ_KtzvOp-fvr44-ZLf_v989eb69veMjnV3pvRCblINjGuLKfUzm5W88gkNUpJIahic_t4VIILbh1diFqYpa7VUjBHr7p3p72HnH5tvlS9QjkeaqJPW9FCUqE4Jf8FiWKSi1E0kJ1Am1Mp2S_6kGE1-bcmWB-90Ht98kIfvdBY6qZ0G3tz3r_Nq3ePQ2fxG_D2DJhiTViyiRbKIycZpuMoG_fhxPkm2wP4rIsFH6130OSt2iX49yV_ADl2qYw</recordid><startdate>200701</startdate><enddate>200701</enddate><creator>Kim, Jee Youn</creator><creator>Yoon, Yeo Dae</creator><creator>Ahn, Ji Mi</creator><creator>Kang, Jong Soon</creator><creator>Park, Song-Kyu</creator><creator>Lee, Kiho</creator><creator>Song, Kyung Bin</creator><creator>Kim, Hwan Mook</creator><creator>Han, Sang-Bae</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>200701</creationdate><title>Angelan isolated from Angelica gigas Nakai induces dendritic cell maturation through toll-like receptor 4</title><author>Kim, Jee Youn ; Yoon, Yeo Dae ; Ahn, Ji Mi ; Kang, Jong Soon ; Park, Song-Kyu ; Lee, Kiho ; Song, Kyung Bin ; Kim, Hwan Mook ; Han, Sang-Bae</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c487t-ea2d68f847459c533cbdb9b2483a99866394b006296565cd3f19f4c3d965864d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Angelan</topic><topic>Angelica</topic><topic>Angelica - chemistry</topic><topic>Angelica gigas Nakai</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cell Differentiation - drug effects</topic><topic>Cells, Cultured</topic><topic>Cytokines - immunology</topic><topic>Dendritic cells</topic><topic>Dendritic Cells - cytology</topic><topic>Dendritic Cells - drug effects</topic><topic>Dendritic Cells - immunology</topic><topic>Endocytosis - drug effects</topic><topic>Female</topic><topic>Lymphocyte Culture Test, Mixed</topic><topic>Medical sciences</topic><topic>Melanoma, Experimental - drug therapy</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Mice, Inbred C3H</topic><topic>Mice, Inbred C57BL</topic><topic>Pharmacology. Drug treatments</topic><topic>Polysaccharides</topic><topic>Polysaccharides - isolation & purification</topic><topic>Polysaccharides - pharmacology</topic><topic>Spleen - cytology</topic><topic>T-Lymphocytes - immunology</topic><topic>Toll-like receptor 4</topic><topic>Toll-Like Receptor 4 - immunology</topic><topic>Xenograft Model Antitumor Assays</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Jee Youn</creatorcontrib><creatorcontrib>Yoon, Yeo Dae</creatorcontrib><creatorcontrib>Ahn, Ji Mi</creatorcontrib><creatorcontrib>Kang, Jong Soon</creatorcontrib><creatorcontrib>Park, Song-Kyu</creatorcontrib><creatorcontrib>Lee, Kiho</creatorcontrib><creatorcontrib>Song, Kyung Bin</creatorcontrib><creatorcontrib>Kim, Hwan Mook</creatorcontrib><creatorcontrib>Han, Sang-Bae</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>International immunopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Jee Youn</au><au>Yoon, Yeo Dae</au><au>Ahn, Ji Mi</au><au>Kang, Jong Soon</au><au>Park, Song-Kyu</au><au>Lee, Kiho</au><au>Song, Kyung Bin</au><au>Kim, Hwan Mook</au><au>Han, Sang-Bae</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Angelan isolated from Angelica gigas Nakai induces dendritic cell maturation through toll-like receptor 4</atitle><jtitle>International immunopharmacology</jtitle><addtitle>Int Immunopharmacol</addtitle><date>2007-01</date><risdate>2007</risdate><volume>7</volume><issue>1</issue><spage>78</spage><epage>87</epage><pages>78-87</pages><issn>1567-5769</issn><eissn>1878-1705</eissn><abstract>During the evolution of neoplastic diseases, dendritic cell (DC) functions are usually attenuated, and this presents a problem to DC-based immunotherapies against cancer. Here, we investigated the effects of angelan, an acidic polysaccharide isolated from Angelica gigas Nakai, on DC maturation. Angelan efficiently increased the maturation of tlr4+/+ DCs from C57BL/6 and C3H/HeN mice, but not tlr4−/− DCs from C3H/HeJ mice. Phenotypic maturation was confirmed by the elevated expressions of CD80, CD86, and MHC-class II molecules, and functional maturation by increased IL-12 production, enhanced allogenic T cell stimulation, and decreased endocytosis. Angelan was found to activate ERK and NF-κB, which are signaling molecules down-stream of toll-like receptor-4 (TLR4) receptors. Angelan-treated mature DC more effectively inhibited B16F10 tumor growth than immature DCs in syngenic murine tumor model. These results indicate that angelan induces DC maturation via TLR4 signaling pathways and suggest the possible use of angelan in DC-based immunotherapies.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>17161820</pmid><doi>10.1016/j.intimp.2006.08.017</doi><tpages>10</tpages></addata></record> |
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| ispartof | International immunopharmacology, 2007-01, Vol.7 (1), p.78-87 |
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| subjects | Angelan Angelica Angelica - chemistry Angelica gigas Nakai Animals Biological and medical sciences Cell Differentiation - drug effects Cells, Cultured Cytokines - immunology Dendritic cells Dendritic Cells - cytology Dendritic Cells - drug effects Dendritic Cells - immunology Endocytosis - drug effects Female Lymphocyte Culture Test, Mixed Medical sciences Melanoma, Experimental - drug therapy Mice Mice, Inbred BALB C Mice, Inbred C3H Mice, Inbred C57BL Pharmacology. Drug treatments Polysaccharides Polysaccharides - isolation & purification Polysaccharides - pharmacology Spleen - cytology T-Lymphocytes - immunology Toll-like receptor 4 Toll-Like Receptor 4 - immunology Xenograft Model Antitumor Assays |
| title | Angelan isolated from Angelica gigas Nakai induces dendritic cell maturation through toll-like receptor 4 |
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