Coronary Vessel Development Is Dependent on the Type III Transforming Growth Factor β Receptor

Transforming growth factor (TGF)β receptor III (TGFβR3), or β-glycan, binds all 3 TGFβ ligands and inhibin with high affinity but lacks the serine/threonine kinase domain found in the type I and type II receptors (TGFβR1, TGFβR2). TGFβR3 facilitates signaling via TGFβR1/TGFβR2 but also has been sugg...

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Veröffentlicht in:	Circulation research 2007-10, Vol.101 (8), p.784-791
Hauptverfasser:	Compton, Leigh A, Potash, Dru A, Brown, Christopher B, Barnett, Joey V
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Coronary Vessels - embryology Coronary Vessels - metabolism Coronary Vessels - pathology Female Fetal Development - genetics Fundamental and applied biological sciences. Psychology Mice Mice, Knockout Pregnancy Proteoglycans - biosynthesis Proteoglycans - deficiency Proteoglycans - genetics Receptors, Transforming Growth Factor beta - biosynthesis Receptors, Transforming Growth Factor beta - deficiency Receptors, Transforming Growth Factor beta - genetics Vertebrates: cardiovascular system
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