Improvement of nutritional status and incidence of infection in hospitalised, enterally fed elderly by feeding of fermented milk containing probiotic Lactobacillus johnsonii La1 (NCC533)
Probiotics have potential to improve host immunity; however, there is less evidence showing their efficacy against infections and nutritional status in the elderly. We conducted a double-blinded feeding trial in the elderly to elucidate the effect of fermented milk containing Lactobacillus johnsonii...
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| Veröffentlicht in: | British journal of nutrition 2007-11, Vol.98 (5), p.969-977 |
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| creator | Fukushima, Yoichi Miyaguchi, Shingo Yamano, Toshihiko Kaburagi, Tomoko Iino, Hisakazu Ushida, Kazunari Sato, Kazuto |
| description | Probiotics have potential to improve host immunity; however, there is less evidence showing their efficacy against infections and nutritional status in the elderly. We conducted a double-blinded feeding trial in the elderly to elucidate the effect of fermented milk containing Lactobacillus johnsonii La1 (LC1®) on infections and nutritional status. Twenty-four completely enterally fed elderly in-patients aged over 70 years were randomly assigned into two groups. All subjects were administered 3768 kJ (900 kcal)/d of total enteral nutrition (EN) through tube feeding for 12 weeks. Subjects in the LC1 group were administered 373 kJ (89 kcal)/d of LC1 fermented milk after feeding of 3395 kJ (811 kcal)/d of EN for 12 weeks. In the control group, 373 kJ/d of the same EN was replaced from the fermented milk. In the LC1 group, the percentage of days with infections during the run-in observation period was 15·4 (sd 17·3) %, which significantly decreased to 5·7 (sd 8·1) % during the intervention period (P = 0·018), and the reduction was larger than that of the control group (P = 0·047). Blood Hb increased (P |
| doi_str_mv | 10.1017/S0007114507764723 |
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We conducted a double-blinded feeding trial in the elderly to elucidate the effect of fermented milk containing Lactobacillus johnsonii La1 (LC1®) on infections and nutritional status. Twenty-four completely enterally fed elderly in-patients aged over 70 years were randomly assigned into two groups. All subjects were administered 3768 kJ (900 kcal)/d of total enteral nutrition (EN) through tube feeding for 12 weeks. Subjects in the LC1 group were administered 373 kJ (89 kcal)/d of LC1 fermented milk after feeding of 3395 kJ (811 kcal)/d of EN for 12 weeks. In the control group, 373 kJ/d of the same EN was replaced from the fermented milk. In the LC1 group, the percentage of days with infections during the run-in observation period was 15·4 (sd 17·3) %, which significantly decreased to 5·7 (sd 8·1) % during the intervention period (P = 0·018), and the reduction was larger than that of the control group (P = 0·047). Blood Hb increased (P < 0·05), and there was a tendency towards an increase in serum albumin and a decrease in TNF-α (a pro-inflammatory cytokine) in the LC1 group. There was a trend towards an increase in blood phagocytic activity (a natural immunity marker) in the subjects whose initial level was low in the LC1 group. There were no changes in those parameters in the control group. Administration of fermented milk containing the probiotic L. johnsonii La1 may contribute to suppressing infections by improving nutritional and immunological status in the elderly.</description><identifier>ISSN: 0007-1145</identifier><identifier>EISSN: 1475-2662</identifier><identifier>DOI: 10.1017/S0007114507764723</identifier><identifier>PMID: 17617944</identifier><identifier>CODEN: BJNUAV</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>Aged ; Aged, 80 and over ; Animals ; Antibiotics ; Bacteria ; Biological and medical sciences ; Blood ; Body Temperature ; Cross Infection - prevention & control ; Diet ; dietary supplements ; disease incidence ; Double-Blind Method ; elderly ; Elderly enterally fed in-patients ; elderly nutrition ; Energy Intake ; enteral feeding ; Enteral nutrition ; Enteral Nutrition - methods ; Feces - microbiology ; Feeding. Feeding behavior ; Female ; Fermentation ; fermented milk ; Fundamental and applied biological sciences. Psychology ; Hospitalization ; Hospitals ; Human studies ; Humans ; immune system ; Infection ; Lactobacillus ; Lactobacillus johnsonii ; Lactobacillus johnsonii La1 NCC533 ; Male ; Milk ; Milk - microbiology ; Nutrition ; nutrition assessment ; Nutritional Status ; patients ; Phagocytosis ; Probiotics ; Probiotics - therapeutic use ; Staphylococcus infections ; Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><ispartof>British journal of nutrition, 2007-11, Vol.98 (5), p.969-977</ispartof><rights>Copyright © The Authors 2007</rights><rights>2007 INIST-CNRS</rights><rights>The Authors</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c493t-eed786540db884675930fa06bbab0c3e2d36712da56cb493bc64dd7db8f811123</citedby><cites>FETCH-LOGICAL-c493t-eed786540db884675930fa06bbab0c3e2d36712da56cb493bc64dd7db8f811123</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.cambridge.org/core/product/identifier/S0007114507764723/type/journal_article$$EHTML$$P50$$Gcambridge$$H</linktohtml><link.rule.ids>164,314,780,784,27924,27925,55628</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19194487$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17617944$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fukushima, Yoichi</creatorcontrib><creatorcontrib>Miyaguchi, Shingo</creatorcontrib><creatorcontrib>Yamano, Toshihiko</creatorcontrib><creatorcontrib>Kaburagi, Tomoko</creatorcontrib><creatorcontrib>Iino, Hisakazu</creatorcontrib><creatorcontrib>Ushida, Kazunari</creatorcontrib><creatorcontrib>Sato, Kazuto</creatorcontrib><title>Improvement of nutritional status and incidence of infection in hospitalised, enterally fed elderly by feeding of fermented milk containing probiotic Lactobacillus johnsonii La1 (NCC533)</title><title>British journal of nutrition</title><addtitle>Br J Nutr</addtitle><description>Probiotics have potential to improve host immunity; however, there is less evidence showing their efficacy against infections and nutritional status in the elderly. We conducted a double-blinded feeding trial in the elderly to elucidate the effect of fermented milk containing Lactobacillus johnsonii La1 (LC1®) on infections and nutritional status. Twenty-four completely enterally fed elderly in-patients aged over 70 years were randomly assigned into two groups. All subjects were administered 3768 kJ (900 kcal)/d of total enteral nutrition (EN) through tube feeding for 12 weeks. Subjects in the LC1 group were administered 373 kJ (89 kcal)/d of LC1 fermented milk after feeding of 3395 kJ (811 kcal)/d of EN for 12 weeks. In the control group, 373 kJ/d of the same EN was replaced from the fermented milk. In the LC1 group, the percentage of days with infections during the run-in observation period was 15·4 (sd 17·3) %, which significantly decreased to 5·7 (sd 8·1) % during the intervention period (P = 0·018), and the reduction was larger than that of the control group (P = 0·047). Blood Hb increased (P < 0·05), and there was a tendency towards an increase in serum albumin and a decrease in TNF-α (a pro-inflammatory cytokine) in the LC1 group. There was a trend towards an increase in blood phagocytic activity (a natural immunity marker) in the subjects whose initial level was low in the LC1 group. There were no changes in those parameters in the control group. Administration of fermented milk containing the probiotic L. johnsonii La1 may contribute to suppressing infections by improving nutritional and immunological status in the elderly.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Animals</subject><subject>Antibiotics</subject><subject>Bacteria</subject><subject>Biological and medical sciences</subject><subject>Blood</subject><subject>Body Temperature</subject><subject>Cross Infection - prevention & control</subject><subject>Diet</subject><subject>dietary supplements</subject><subject>disease incidence</subject><subject>Double-Blind Method</subject><subject>elderly</subject><subject>Elderly enterally fed in-patients</subject><subject>elderly nutrition</subject><subject>Energy Intake</subject><subject>enteral feeding</subject><subject>Enteral nutrition</subject><subject>Enteral Nutrition - methods</subject><subject>Feces - microbiology</subject><subject>Feeding. Feeding behavior</subject><subject>Female</subject><subject>Fermentation</subject><subject>fermented milk</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hospitalization</subject><subject>Hospitals</subject><subject>Human studies</subject><subject>Humans</subject><subject>immune system</subject><subject>Infection</subject><subject>Lactobacillus</subject><subject>Lactobacillus johnsonii</subject><subject>Lactobacillus johnsonii La1 NCC533</subject><subject>Male</subject><subject>Milk</subject><subject>Milk - microbiology</subject><subject>Nutrition</subject><subject>nutrition assessment</subject><subject>Nutritional Status</subject><subject>patients</subject><subject>Phagocytosis</subject><subject>Probiotics</subject><subject>Probiotics - therapeutic use</subject><subject>Staphylococcus infections</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><issn>0007-1145</issn><issn>1475-2662</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkt-K1DAUxoso7rj6AN5oWFAUrCZNm7SXOrjj4qDIuiLelDRJZzObJmOSivtqPp2nTnFAEa_y5_ud75yTkyy7T_Bzggl_cY4x5oSUFeaclbygN7IFKXmVF4wVN7PFJOeTfpTdiXELx5rg5nZ2RDgjvCnLRfbjbNgF_00P2iXke-TGFEwy3gmLYhJpjEg4hYyTRmkn9cQY12s5MbBDlz7uTBLWRK2eIXDRQVh7jXqtkLZKB9h301Er4zZTeK_DlA30wdgrJL1LwrhJhEo645ORaC1k8p2QxlqoYOsvXfTOGLgn6Mm75bKi9Ond7FYvbNT35vU4uzh9_XH5Jl-_X50tX65zWTY05ZCY16wqserqumS8aijuBWZdJzosqS4UZZwUSlRMdhDRSVYqxYHua0JIQY-zx3tfKO_rqGNqBxOltlY47cfYshoMMOP_BQuMK1YTCuDJH-DWjwGeHBhCa0rYLzeyh2TwMQbdt7tgBhGuW4LbafztX-OHmAez8dgNWh0i5nkD8GgGRJTC9kHAYOOBawhQ9ZQ833MmJv39ty7CVQul8aplqw_t28_1q9Mvq0_tCviHe74XvhWbAJ4X5wUmFL5cyZqGAUHndsTQBaM2-tD0vxv6CfEZ4V8</recordid><startdate>20071101</startdate><enddate>20071101</enddate><creator>Fukushima, Yoichi</creator><creator>Miyaguchi, Shingo</creator><creator>Yamano, Toshihiko</creator><creator>Kaburagi, Tomoko</creator><creator>Iino, Hisakazu</creator><creator>Ushida, Kazunari</creator><creator>Sato, Kazuto</creator><general>Cambridge University Press</general><scope>FBQ</scope><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7T5</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7QL</scope><scope>7QO</scope><scope>7T7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20071101</creationdate><title>Improvement of nutritional status and incidence of infection in hospitalised, enterally fed elderly by feeding of fermented milk containing probiotic Lactobacillus johnsonii La1 (NCC533)</title><author>Fukushima, Yoichi ; Miyaguchi, Shingo ; Yamano, Toshihiko ; Kaburagi, Tomoko ; Iino, Hisakazu ; Ushida, Kazunari ; Sato, Kazuto</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c493t-eed786540db884675930fa06bbab0c3e2d36712da56cb493bc64dd7db8f811123</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Animals</topic><topic>Antibiotics</topic><topic>Bacteria</topic><topic>Biological and medical sciences</topic><topic>Blood</topic><topic>Body Temperature</topic><topic>Cross Infection - prevention & control</topic><topic>Diet</topic><topic>dietary supplements</topic><topic>disease incidence</topic><topic>Double-Blind Method</topic><topic>elderly</topic><topic>Elderly enterally fed in-patients</topic><topic>elderly nutrition</topic><topic>Energy Intake</topic><topic>enteral feeding</topic><topic>Enteral nutrition</topic><topic>Enteral Nutrition - methods</topic><topic>Feces - microbiology</topic><topic>Feeding. Feeding behavior</topic><topic>Female</topic><topic>Fermentation</topic><topic>fermented milk</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hospitalization</topic><topic>Hospitals</topic><topic>Human studies</topic><topic>Humans</topic><topic>immune system</topic><topic>Infection</topic><topic>Lactobacillus</topic><topic>Lactobacillus johnsonii</topic><topic>Lactobacillus johnsonii La1 NCC533</topic><topic>Male</topic><topic>Milk</topic><topic>Milk - microbiology</topic><topic>Nutrition</topic><topic>nutrition assessment</topic><topic>Nutritional Status</topic><topic>patients</topic><topic>Phagocytosis</topic><topic>Probiotics</topic><topic>Probiotics - therapeutic use</topic><topic>Staphylococcus infections</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fukushima, Yoichi</creatorcontrib><creatorcontrib>Miyaguchi, Shingo</creatorcontrib><creatorcontrib>Yamano, Toshihiko</creatorcontrib><creatorcontrib>Kaburagi, Tomoko</creatorcontrib><creatorcontrib>Iino, Hisakazu</creatorcontrib><creatorcontrib>Ushida, Kazunari</creatorcontrib><creatorcontrib>Sato, Kazuto</creatorcontrib><collection>AGRIS</collection><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fukushima, Yoichi</au><au>Miyaguchi, Shingo</au><au>Yamano, Toshihiko</au><au>Kaburagi, Tomoko</au><au>Iino, Hisakazu</au><au>Ushida, Kazunari</au><au>Sato, Kazuto</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Improvement of nutritional status and incidence of infection in hospitalised, enterally fed elderly by feeding of fermented milk containing probiotic Lactobacillus johnsonii La1 (NCC533)</atitle><jtitle>British journal of nutrition</jtitle><addtitle>Br J Nutr</addtitle><date>2007-11-01</date><risdate>2007</risdate><volume>98</volume><issue>5</issue><spage>969</spage><epage>977</epage><pages>969-977</pages><issn>0007-1145</issn><eissn>1475-2662</eissn><coden>BJNUAV</coden><abstract>Probiotics have potential to improve host immunity; however, there is less evidence showing their efficacy against infections and nutritional status in the elderly. We conducted a double-blinded feeding trial in the elderly to elucidate the effect of fermented milk containing Lactobacillus johnsonii La1 (LC1®) on infections and nutritional status. Twenty-four completely enterally fed elderly in-patients aged over 70 years were randomly assigned into two groups. All subjects were administered 3768 kJ (900 kcal)/d of total enteral nutrition (EN) through tube feeding for 12 weeks. Subjects in the LC1 group were administered 373 kJ (89 kcal)/d of LC1 fermented milk after feeding of 3395 kJ (811 kcal)/d of EN for 12 weeks. In the control group, 373 kJ/d of the same EN was replaced from the fermented milk. In the LC1 group, the percentage of days with infections during the run-in observation period was 15·4 (sd 17·3) %, which significantly decreased to 5·7 (sd 8·1) % during the intervention period (P = 0·018), and the reduction was larger than that of the control group (P = 0·047). Blood Hb increased (P < 0·05), and there was a tendency towards an increase in serum albumin and a decrease in TNF-α (a pro-inflammatory cytokine) in the LC1 group. There was a trend towards an increase in blood phagocytic activity (a natural immunity marker) in the subjects whose initial level was low in the LC1 group. There were no changes in those parameters in the control group. Administration of fermented milk containing the probiotic L. johnsonii La1 may contribute to suppressing infections by improving nutritional and immunological status in the elderly.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><pmid>17617944</pmid><doi>10.1017/S0007114507764723</doi><tpages>9</tpages></addata></record> |
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| subjects | Aged Aged, 80 and over Animals Antibiotics Bacteria Biological and medical sciences Blood Body Temperature Cross Infection - prevention & control Diet dietary supplements disease incidence Double-Blind Method elderly Elderly enterally fed in-patients elderly nutrition Energy Intake enteral feeding Enteral nutrition Enteral Nutrition - methods Feces - microbiology Feeding. Feeding behavior Female Fermentation fermented milk Fundamental and applied biological sciences. Psychology Hospitalization Hospitals Human studies Humans immune system Infection Lactobacillus Lactobacillus johnsonii Lactobacillus johnsonii La1 NCC533 Male Milk Milk - microbiology Nutrition nutrition assessment Nutritional Status patients Phagocytosis Probiotics Probiotics - therapeutic use Staphylococcus infections Vertebrates: anatomy and physiology, studies on body, several organs or systems |
| title | Improvement of nutritional status and incidence of infection in hospitalised, enterally fed elderly by feeding of fermented milk containing probiotic Lactobacillus johnsonii La1 (NCC533) |
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