Inhibitiory effects of gold(III) ions on ribonuclease and deoxyribonuclease

Inhibitory effects of gold(III) ions (Au(III)) on ribonuclease A (RNase A) and deoxyribonuclease I (DNase I) were investigated at neutral pH. RNase A was completely inhibited by 3 molar equivalents of Au(III) ions. DNase I was inhibited by 10 molar equivalents of Au(III) ions. Stoichiometric analyse...

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Veröffentlicht in:	Journal of inorganic biochemistry 2007, Vol.101 (1), p.180-186
Hauptverfasser:	Maruyama, Tatsuo, Sonokawa, Saori, Matsushita, Hironari, Goto, Masahiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Circular Dichroism Deoxyribonucleases - antagonists & inhibitors DNase Enzyme Inhibitors - pharmacology Gold - pharmacology Gold ion Precious metal ions Reversible inhibition Ribonucleases - antagonists & inhibitors RNase
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