Antinociceptive effect of antisense oligonucleotides against the vanilloid receptor VR1/TRPV1

To examine the role of the vanilloid receptor TRPV1 in neuropathic pain, we assessed the effects of the receptor antagonist thioxo-BCTC and antisense oligonucleotides against the TRPV1 mRNA in a rat model of spinal nerve ligation. In order to identify accessible sites on the mRNA of TRPV1, the RNase...

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Veröffentlicht in:	Neurochemistry international 2007, Vol.50 (1), p.281-290
Hauptverfasser:	Christoph, Thomas, Gillen, Clemens, Mika, Joanna, Grünweller, Arnold, Schäfer, Martin K.-H., Schiene, Klaus, Frank, Robert, Jostock, Ruth, Bahrenberg, Gregor, Weihe, Eberhard, Erdmann, Volker A., Kurreck, Jens
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesics - pharmacology Animals Antisense oligonucleotides Base Sequence Biological and medical sciences Capsaicin receptor Cercopithecus aethiops CHO Cells COS Cells Cranial nerves. Spinal roots. Peripheral nerves. Autonomic nervous system. Gustation. Olfaction Cricetinae Cricetulus DNA Primers Fundamental and applied biological sciences. Psychology Immunohistochemistry Male Medical sciences Microscopy, Fluorescence Nervous system (semeiology, syndromes) Neurology Neuropathic pain Oligonucleotides, Antisense - pharmacology Rats Rats, Sprague-Dawley Spinal Cord - drug effects Spinal Cord - metabolism Thioxo-BCTC TRPV Cation Channels - drug effects Vanilloid receptor Vertebrates: nervous system and sense organs
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