Alterations in D-amino acid levels in the brains of mice and rats after the administration of D-amino acids

To mutant ddY/DAO- mice lacking D-amino-acid oxidase activity and normal ddY/DAO⁺ mice, five D-amino acids (D-Asp, D-Ser, D-Ala, D-Leu and D-Pro) were orally administered for two weeks, and the D-amino acid levels were examined in seven brain regions. The levels of D-Asp markedly increased in the pi...

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