SNPs on Chips: The Hidden Genetic Code in Expression Arrays

Gene expression microarray analysis in postmortem brains is one of the fastest growing fields of psychiatric research. Here we show that common polymorphisms (SNPs) present on probe sets can masquerade as significant “gene expression” differences. After first observing this artifact in the Catechol-...

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Veröffentlicht in:	Biological psychiatry (1969) 2007, Vol.61 (1), p.13-16
Hauptverfasser:	Sliwerska, Elzbieta, Meng, Fan, Speed, Terence P, Jones, Edward G, Bunney, William E, Akil, Huda, Watson, Stanley J, Burmeister, Margit
Format:	Artikel
Sprache:	eng
Schlagworte:	Affymetrix Analysis of Variance Catechol O-Methyltransferase - genetics Catechol-O-Methyl-Transferase gene expression Gene Expression - physiology genetic association Genetic Code Genotype Humans microarray Oligonucleotide Array Sequence Analysis Polymorphism, Genetic postmortem brain Psychiatry
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