Antidepressant behavioral effects of duloxetine and fluoxetine in the rat forced swimming test
To compare the effects of the antidepressant drugs duloxetine and fluoxetine on depressive behaviors in rodents. Eighteen male Wistar rats were given systemic injections of duloxetine, fluoxetine, or saline prior to a Forced Swimming Test (FST). Immobility and number of stops were measured. Rats giv...
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| Veröffentlicht in: | Acta cirúrgica brasileira 2007-10, Vol.22 (5), p.351-354 |
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| container_title | Acta cirúrgica brasileira |
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| creator | Ciulla, Leandro Menezes, Honório Sampaio Bueno, Bárbara Beatriz Moreira Schuh, Alexandre Alves, Rafael José Vargas Abegg, Milena Pacheco |
| description | To compare the effects of the antidepressant drugs duloxetine and fluoxetine on depressive behaviors in rodents.
Eighteen male Wistar rats were given systemic injections of duloxetine, fluoxetine, or saline prior to a Forced Swimming Test (FST). Immobility and number of stops were measured.
Rats given injections of fluoxetine displayed significantly less immobility (p = 0.02) and fewer stops than the control group (p = 0.003). Duloxetine significantly reduced the number of stops (p = 0.003), but did not effect immobility (p = 0.48).
Duloxetine and fluoxetine reduced depressive behaviors in the Forced FST. However, our findings suggest that fluoxetine is more effective than duloxetine. |
| doi_str_mv | 10.1590/s0102-86502007000500005 |
| format | Article |
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Eighteen male Wistar rats were given systemic injections of duloxetine, fluoxetine, or saline prior to a Forced Swimming Test (FST). Immobility and number of stops were measured.
Rats given injections of fluoxetine displayed significantly less immobility (p = 0.02) and fewer stops than the control group (p = 0.003). Duloxetine significantly reduced the number of stops (p = 0.003), but did not effect immobility (p = 0.48).
Duloxetine and fluoxetine reduced depressive behaviors in the Forced FST. However, our findings suggest that fluoxetine is more effective than duloxetine.</description><identifier>ISSN: 0102-8650</identifier><identifier>EISSN: 0102-8650</identifier><identifier>DOI: 10.1590/s0102-86502007000500005</identifier><identifier>PMID: 17923954</identifier><language>eng</language><publisher>Brazil</publisher><subject>Analysis of Variance ; Animals ; Antidepressive Agents - pharmacology ; Depression - drug therapy ; Duloxetine Hydrochloride ; Fluoxetine - pharmacology ; Immobilization - psychology ; Male ; Models, Animal ; Motor Activity - drug effects ; Motor Activity - physiology ; Rats ; Rats, Wistar ; Statistics, Nonparametric ; Swimming - psychology ; Thiophenes - pharmacology</subject><ispartof>Acta cirúrgica brasileira, 2007-10, Vol.22 (5), p.351-354</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c465t-7b4cf3578e69f1632f617250e6f49d83baba8de76ffc8c68188872e4afbe8e403</citedby><cites>FETCH-LOGICAL-c465t-7b4cf3578e69f1632f617250e6f49d83baba8de76ffc8c68188872e4afbe8e403</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,860,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17923954$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ciulla, Leandro</creatorcontrib><creatorcontrib>Menezes, Honório Sampaio</creatorcontrib><creatorcontrib>Bueno, Bárbara Beatriz Moreira</creatorcontrib><creatorcontrib>Schuh, Alexandre</creatorcontrib><creatorcontrib>Alves, Rafael José Vargas</creatorcontrib><creatorcontrib>Abegg, Milena Pacheco</creatorcontrib><title>Antidepressant behavioral effects of duloxetine and fluoxetine in the rat forced swimming test</title><title>Acta cirúrgica brasileira</title><addtitle>Acta Cir Bras</addtitle><description>To compare the effects of the antidepressant drugs duloxetine and fluoxetine on depressive behaviors in rodents.
Eighteen male Wistar rats were given systemic injections of duloxetine, fluoxetine, or saline prior to a Forced Swimming Test (FST). Immobility and number of stops were measured.
Rats given injections of fluoxetine displayed significantly less immobility (p = 0.02) and fewer stops than the control group (p = 0.003). Duloxetine significantly reduced the number of stops (p = 0.003), but did not effect immobility (p = 0.48).
Duloxetine and fluoxetine reduced depressive behaviors in the Forced FST. However, our findings suggest that fluoxetine is more effective than duloxetine.</description><subject>Analysis of Variance</subject><subject>Animals</subject><subject>Antidepressive Agents - pharmacology</subject><subject>Depression - drug therapy</subject><subject>Duloxetine Hydrochloride</subject><subject>Fluoxetine - pharmacology</subject><subject>Immobilization - psychology</subject><subject>Male</subject><subject>Models, Animal</subject><subject>Motor Activity - drug effects</subject><subject>Motor Activity - physiology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Statistics, Nonparametric</subject><subject>Swimming - psychology</subject><subject>Thiophenes - pharmacology</subject><issn>0102-8650</issn><issn>0102-8650</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNplkElPwzAQhS0EomX5C-ATt8A4TmznWFVsUiUOwJXIccbUKEuxHZZ_T6qWReIyi-bNe9JHyCmDc5YXcBGAQZookUMKIAEgh3XZIdOfw-6feUIOQngBYJlgfJ9MmCxSXuTZlDzNuuhqXHkMQXeRVrjUb673uqFoLZoYaG9pPTT9B0bXIdVdTW0zfK-uo3GJ1OtIbe8N1jS8u7Z13TONGOIR2bO6CXi87Yfk8eryYX6TLO6ub-ezRWIykcdEVpmxPJcKRWGZ4KkVTKY5oLBZUSte6UqrGqWw1igjFFNKyRQzbStUmAE_JGcb35XvX4cxuGxdMNg0usN-CKVQfHQFNgrlRmh8H4JHW668a7X_LBmUa7Tl_Zpa-Q_t-HmyjRiqFuvfvy1L_gX1UnXS</recordid><startdate>20071001</startdate><enddate>20071001</enddate><creator>Ciulla, Leandro</creator><creator>Menezes, Honório Sampaio</creator><creator>Bueno, Bárbara Beatriz Moreira</creator><creator>Schuh, Alexandre</creator><creator>Alves, Rafael José Vargas</creator><creator>Abegg, Milena Pacheco</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20071001</creationdate><title>Antidepressant behavioral effects of duloxetine and fluoxetine in the rat forced swimming test</title><author>Ciulla, Leandro ; Menezes, Honório Sampaio ; Bueno, Bárbara Beatriz Moreira ; Schuh, Alexandre ; Alves, Rafael José Vargas ; Abegg, Milena Pacheco</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c465t-7b4cf3578e69f1632f617250e6f49d83baba8de76ffc8c68188872e4afbe8e403</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Analysis of Variance</topic><topic>Animals</topic><topic>Antidepressive Agents - pharmacology</topic><topic>Depression - drug therapy</topic><topic>Duloxetine Hydrochloride</topic><topic>Fluoxetine - pharmacology</topic><topic>Immobilization - psychology</topic><topic>Male</topic><topic>Models, Animal</topic><topic>Motor Activity - drug effects</topic><topic>Motor Activity - physiology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Statistics, Nonparametric</topic><topic>Swimming - psychology</topic><topic>Thiophenes - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ciulla, Leandro</creatorcontrib><creatorcontrib>Menezes, Honório Sampaio</creatorcontrib><creatorcontrib>Bueno, Bárbara Beatriz Moreira</creatorcontrib><creatorcontrib>Schuh, Alexandre</creatorcontrib><creatorcontrib>Alves, Rafael José Vargas</creatorcontrib><creatorcontrib>Abegg, Milena Pacheco</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Acta cirúrgica brasileira</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ciulla, Leandro</au><au>Menezes, Honório Sampaio</au><au>Bueno, Bárbara Beatriz Moreira</au><au>Schuh, Alexandre</au><au>Alves, Rafael José Vargas</au><au>Abegg, Milena Pacheco</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antidepressant behavioral effects of duloxetine and fluoxetine in the rat forced swimming test</atitle><jtitle>Acta cirúrgica brasileira</jtitle><addtitle>Acta Cir Bras</addtitle><date>2007-10-01</date><risdate>2007</risdate><volume>22</volume><issue>5</issue><spage>351</spage><epage>354</epage><pages>351-354</pages><issn>0102-8650</issn><eissn>0102-8650</eissn><abstract>To compare the effects of the antidepressant drugs duloxetine and fluoxetine on depressive behaviors in rodents.
Eighteen male Wistar rats were given systemic injections of duloxetine, fluoxetine, or saline prior to a Forced Swimming Test (FST). Immobility and number of stops were measured.
Rats given injections of fluoxetine displayed significantly less immobility (p = 0.02) and fewer stops than the control group (p = 0.003). Duloxetine significantly reduced the number of stops (p = 0.003), but did not effect immobility (p = 0.48).
Duloxetine and fluoxetine reduced depressive behaviors in the Forced FST. However, our findings suggest that fluoxetine is more effective than duloxetine.</abstract><cop>Brazil</cop><pmid>17923954</pmid><doi>10.1590/s0102-86502007000500005</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Analysis of Variance Animals Antidepressive Agents - pharmacology Depression - drug therapy Duloxetine Hydrochloride Fluoxetine - pharmacology Immobilization - psychology Male Models, Animal Motor Activity - drug effects Motor Activity - physiology Rats Rats, Wistar Statistics, Nonparametric Swimming - psychology Thiophenes - pharmacology |
| title | Antidepressant behavioral effects of duloxetine and fluoxetine in the rat forced swimming test |
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