Identification of a regulatory cis-element within the 3′-untranslated region of the murine inducible nitric oxide synthase (iNOS) mRNA; interaction with heterogeneous nuclear ribonucleoproteins I and L and role in the iNOS gene expression

The aim of this study was to investigate the role of heterogeneous nuclear ribonucleoprotein I (hnRNPI) and hnRNPL in the regulation of the murine inducible nitric oxide synthase (iNOS) gene during inflammation. Treatment of mice with lipopolysaccharide (LPS)/ d-galactosamine, or of RAW 264.7 cells...

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Veröffentlicht in:	Molecular Immunology 2007, Vol.44 (4), p.434-442
Hauptverfasser:	Söderberg, Malin, Raffalli-Mathieu, Françoise, Lang, Matti A.
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated Regions - genetics 3' Untranslated Regions - metabolism 3′-UTR Animals Gene Expression Regulation, Enzymologic Heterogeneous-Nuclear Ribonucleoprotein L - genetics Heterogeneous-Nuclear Ribonucleoprotein L - metabolism Heterogeneous-Nuclear Ribonucleoproteins - genetics Heterogeneous-Nuclear Ribonucleoproteins - metabolism hnRNP Inflammation - metabolism iNOS Lipopolysaccharides - pharmacology Male Mice Mice, Inbred DBA Nitric Oxide Synthase Type II - genetics Post-transcriptional regulation Protein Binding RNA Processing, Post-Transcriptional RNA, Messenger - genetics RNA, Messenger - metabolism Tumor Necrosis Factor-alpha - pharmacology
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