Purinergic signalling and intercellular Ca2+ wave propagation in the organ of Corti

Abstract Extracellular ATP is a key neuromodulator of visual and auditory sensory epithelia. In the rat cochlea, pharmacological dissection indicates that ATP, acting through a highly sensitive purinergic/IP3 -mediated signaling pathway with (little or) no involvement of ryanodine receptors, is the...

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Veröffentlicht in:	Cell calcium (Edinburgh) 2007-01, Vol.41 (1), p.77-86
Hauptverfasser:	Piazza, Valeria, Ciubotaru, Catalin D, Gale, Jonathan E, Mammano, Fabio
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - metabolism Adenosine Triphosphate - pharmacology Advanced Basic Science Animals Calcium Signaling - drug effects Calcium Signaling - physiology Inositol 1,4,5-Trisphosphate - metabolism Organ Culture Techniques Organ of Corti - drug effects Organ of Corti - metabolism Rats Rats, Sprague-Dawley Receptors, Purinergic P2 - metabolism Receptors, Purinergic P2Y2 Thapsigargin - pharmacology
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