The effect of time of day on the duration of neuromuscular blockade elicited by rocuronium
Summary In a prospective, observational trial, we investigated the influence of time of day on the duration of neuromuscular blockade (NMB) elicited by rocuronium. Forty‐nine patients scheduled for surgery between 08:00 and 02:00 were enrolled after giving written informed consent. Time to neuromusc...
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| Veröffentlicht in: | Anaesthesia 2007-11, Vol.62 (11), p.1114-1120 |
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| creator | Cheeseman, J. F. Merry, A. F. Pawley, M. D. M. De Souza, R. L. Warman, G. R. |
| description | Summary
In a prospective, observational trial, we investigated the influence of time of day on the duration of neuromuscular blockade (NMB) elicited by rocuronium. Forty‐nine patients scheduled for surgery between 08:00 and 02:00 were enrolled after giving written informed consent. Time to neuromuscular recovery was measured following three doses: (1) a fat‐free‐mass (FFM) related induction dose (0.6 mg.kg−1: n = 47); (2) a maintenance dose (20% of the induction dose: n = 42); and (3) a standard 10‐mg dose (n = 35). The extent of NMB was dependent on the time of administration (p = 0.038 General Linear Model Analysis). The maximum effect of 50 min (95% CI 41–59 min) was elicited between 08:00 and 11:00 and the minimum duration of 29 min (95% CI 23–35 min) between 14:00 and 17:00 (p = 0.005). A similar pattern was observed for the maintenance dose. The duration of action of rocuronium is influenced by time of day and this effect is of potential clinical significance and practical relevance to research. |
| doi_str_mv | 10.1111/j.1365-2044.2007.05222.x |
| format | Article |
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In a prospective, observational trial, we investigated the influence of time of day on the duration of neuromuscular blockade (NMB) elicited by rocuronium. Forty‐nine patients scheduled for surgery between 08:00 and 02:00 were enrolled after giving written informed consent. Time to neuromuscular recovery was measured following three doses: (1) a fat‐free‐mass (FFM) related induction dose (0.6 mg.kg−1: n = 47); (2) a maintenance dose (20% of the induction dose: n = 42); and (3) a standard 10‐mg dose (n = 35). The extent of NMB was dependent on the time of administration (p = 0.038 General Linear Model Analysis). The maximum effect of 50 min (95% CI 41–59 min) was elicited between 08:00 and 11:00 and the minimum duration of 29 min (95% CI 23–35 min) between 14:00 and 17:00 (p = 0.005). A similar pattern was observed for the maintenance dose. The duration of action of rocuronium is influenced by time of day and this effect is of potential clinical significance and practical relevance to research.</description><identifier>ISSN: 0003-2409</identifier><identifier>EISSN: 1365-2044</identifier><identifier>DOI: 10.1111/j.1365-2044.2007.05222.x</identifier><identifier>PMID: 17924891</identifier><identifier>CODEN: ANASAB</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adult ; Aged ; Androstanols - administration & dosage ; Androstanols - pharmacology ; Anesthesia ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Anesthesiology ; Biological and medical sciences ; Circadian Rhythm - physiology ; Dose-Response Relationship, Drug ; Drug dosages ; Female ; Humans ; Male ; Medical sciences ; Middle Aged ; Neuromuscular Blockade ; Neuromuscular Junction - drug effects ; Neuromuscular Junction - physiology ; Neuromuscular Nondepolarizing Agents - administration & dosage ; Neuromuscular Nondepolarizing Agents - pharmacology ; Postoperative period ; Prospective Studies ; Surgery ; Time Factors</subject><ispartof>Anaesthesia, 2007-11, Vol.62 (11), p.1114-1120</ispartof><rights>2007 INIST-CNRS</rights><rights>2007 The Authors Journal compilation 2007 The Association of Anaesthetists of Great Britain and Ireland</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4752-eff556aad626f738014ed7528a7e62b430dabf642da82a8a77f7d29dea43e97b3</citedby><cites>FETCH-LOGICAL-c4752-eff556aad626f738014ed7528a7e62b430dabf642da82a8a77f7d29dea43e97b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-2044.2007.05222.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-2044.2007.05222.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,1433,27924,27925,45574,45575,46409,46833</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19159570$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17924891$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cheeseman, J. F.</creatorcontrib><creatorcontrib>Merry, A. F.</creatorcontrib><creatorcontrib>Pawley, M. D. M.</creatorcontrib><creatorcontrib>De Souza, R. L.</creatorcontrib><creatorcontrib>Warman, G. R.</creatorcontrib><title>The effect of time of day on the duration of neuromuscular blockade elicited by rocuronium</title><title>Anaesthesia</title><addtitle>Anaesthesia</addtitle><description>Summary
In a prospective, observational trial, we investigated the influence of time of day on the duration of neuromuscular blockade (NMB) elicited by rocuronium. Forty‐nine patients scheduled for surgery between 08:00 and 02:00 were enrolled after giving written informed consent. Time to neuromuscular recovery was measured following three doses: (1) a fat‐free‐mass (FFM) related induction dose (0.6 mg.kg−1: n = 47); (2) a maintenance dose (20% of the induction dose: n = 42); and (3) a standard 10‐mg dose (n = 35). The extent of NMB was dependent on the time of administration (p = 0.038 General Linear Model Analysis). The maximum effect of 50 min (95% CI 41–59 min) was elicited between 08:00 and 11:00 and the minimum duration of 29 min (95% CI 23–35 min) between 14:00 and 17:00 (p = 0.005). A similar pattern was observed for the maintenance dose. The duration of action of rocuronium is influenced by time of day and this effect is of potential clinical significance and practical relevance to research.</description><subject>Adult</subject><subject>Aged</subject><subject>Androstanols - administration & dosage</subject><subject>Androstanols - pharmacology</subject><subject>Anesthesia</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Anesthesiology</subject><subject>Biological and medical sciences</subject><subject>Circadian Rhythm - physiology</subject><subject>Dose-Response Relationship, Drug</subject><subject>Drug dosages</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neuromuscular Blockade</subject><subject>Neuromuscular Junction - drug effects</subject><subject>Neuromuscular Junction - physiology</subject><subject>Neuromuscular Nondepolarizing Agents - administration & dosage</subject><subject>Neuromuscular Nondepolarizing Agents - pharmacology</subject><subject>Postoperative period</subject><subject>Prospective Studies</subject><subject>Surgery</subject><subject>Time Factors</subject><issn>0003-2409</issn><issn>1365-2044</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkE1r3DAQhkVJabZp_0IQgfRmV1-27EtgCekHhPaSXnoRsjSi2thWIlk0--8rd5cGcqouo5l53pnhRQhTUtPyPu5qytumYkSImhEia9IwxuqnV2jzr3GCNoQQXjFB-lP0NqUdIZR1tHuDTqnsmeh6ukE_734BBufALDg4vPgJ1mj1HocZL6Vpc9SLL0kpz5BjmHIyedQRD2Mw99oW_eiNX8DiYY9jMIWZfZ7eoddOjwneH-MZ-vHp5u76S3X7_fPX6-1tZYRsWFWWN02rtW1Z6yTvCBVgS6PTElo2CE6sHlwrmNUd06UqnbSst6AFh14O_Ax9OMx9iOExQ1rU5JOBcdQzhJxU2_GWCskLePEC3IUc53Kbor3kDSurC9QdIBNDShGceoh-0nGvKFGr-WqnVo_V6rFazVd_zVdPRXp-nJ-HCeyz8Oh2AS6PgE5Gjy7q2fj0zPW06RtJCnd14H77Efb_fYDaftverF_-B2O-n54</recordid><startdate>200711</startdate><enddate>200711</enddate><creator>Cheeseman, J. F.</creator><creator>Merry, A. F.</creator><creator>Pawley, M. D. M.</creator><creator>De Souza, R. L.</creator><creator>Warman, G. R.</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U7</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>200711</creationdate><title>The effect of time of day on the duration of neuromuscular blockade elicited by rocuronium</title><author>Cheeseman, J. F. ; Merry, A. F. ; Pawley, M. D. M. ; De Souza, R. L. ; Warman, G. R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4752-eff556aad626f738014ed7528a7e62b430dabf642da82a8a77f7d29dea43e97b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Androstanols - administration & dosage</topic><topic>Androstanols - pharmacology</topic><topic>Anesthesia</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Anesthesiology</topic><topic>Biological and medical sciences</topic><topic>Circadian Rhythm - physiology</topic><topic>Dose-Response Relationship, Drug</topic><topic>Drug dosages</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neuromuscular Blockade</topic><topic>Neuromuscular Junction - drug effects</topic><topic>Neuromuscular Junction - physiology</topic><topic>Neuromuscular Nondepolarizing Agents - administration & dosage</topic><topic>Neuromuscular Nondepolarizing Agents - pharmacology</topic><topic>Postoperative period</topic><topic>Prospective Studies</topic><topic>Surgery</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cheeseman, J. F.</creatorcontrib><creatorcontrib>Merry, A. F.</creatorcontrib><creatorcontrib>Pawley, M. D. M.</creatorcontrib><creatorcontrib>De Souza, R. L.</creatorcontrib><creatorcontrib>Warman, G. R.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Anaesthesia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cheeseman, J. F.</au><au>Merry, A. F.</au><au>Pawley, M. D. M.</au><au>De Souza, R. L.</au><au>Warman, G. R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effect of time of day on the duration of neuromuscular blockade elicited by rocuronium</atitle><jtitle>Anaesthesia</jtitle><addtitle>Anaesthesia</addtitle><date>2007-11</date><risdate>2007</risdate><volume>62</volume><issue>11</issue><spage>1114</spage><epage>1120</epage><pages>1114-1120</pages><issn>0003-2409</issn><eissn>1365-2044</eissn><coden>ANASAB</coden><abstract>Summary
In a prospective, observational trial, we investigated the influence of time of day on the duration of neuromuscular blockade (NMB) elicited by rocuronium. Forty‐nine patients scheduled for surgery between 08:00 and 02:00 were enrolled after giving written informed consent. Time to neuromuscular recovery was measured following three doses: (1) a fat‐free‐mass (FFM) related induction dose (0.6 mg.kg−1: n = 47); (2) a maintenance dose (20% of the induction dose: n = 42); and (3) a standard 10‐mg dose (n = 35). The extent of NMB was dependent on the time of administration (p = 0.038 General Linear Model Analysis). The maximum effect of 50 min (95% CI 41–59 min) was elicited between 08:00 and 11:00 and the minimum duration of 29 min (95% CI 23–35 min) between 14:00 and 17:00 (p = 0.005). A similar pattern was observed for the maintenance dose. The duration of action of rocuronium is influenced by time of day and this effect is of potential clinical significance and practical relevance to research.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>17924891</pmid><doi>10.1111/j.1365-2044.2007.05222.x</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Androstanols - administration & dosage Androstanols - pharmacology Anesthesia Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Anesthesiology Biological and medical sciences Circadian Rhythm - physiology Dose-Response Relationship, Drug Drug dosages Female Humans Male Medical sciences Middle Aged Neuromuscular Blockade Neuromuscular Junction - drug effects Neuromuscular Junction - physiology Neuromuscular Nondepolarizing Agents - administration & dosage Neuromuscular Nondepolarizing Agents - pharmacology Postoperative period Prospective Studies Surgery Time Factors |
| title | The effect of time of day on the duration of neuromuscular blockade elicited by rocuronium |
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