Anhidrosis: A clue to an underlying autonomic disorder
Abstract We describe a patient with Ross syndrome who had the classic triad of segmental anhidrosis, tonic pupils and hyporeflexia. Dilute pilocarpine (0.1%) instillation in both eyes revealed parasympathetic denervation hypersensitivity. There was evidence of cardiac dysautonomia in the form of a d...
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| Veröffentlicht in: | Journal of clinical neuroscience 2007-01, Vol.14 (1), p.94-96 |
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| creator | Chemmanam, Thomas Pandian, Jeyaraj D Kadyan, Randhir S Bhatti, S.M |
| description | Abstract We describe a patient with Ross syndrome who had the classic triad of segmental anhidrosis, tonic pupils and hyporeflexia. Dilute pilocarpine (0.1%) instillation in both eyes revealed parasympathetic denervation hypersensitivity. There was evidence of cardiac dysautonomia in the form of a decrease in heart rate variability with deep breathing and an abnormal Valsalva response. A thermoregulatory sweat test showed the presence of sweating in the right cheek, neck and upper one-third of the left arm and shoulder only. Sympathetic skin responses were absent in the affected segments of the upper limb. Ross syndrome is a degenerative disorder that progressively involves different fibre populations, starting with autonomic fibres and then involving the unmyelinated and myelinated sensory fibres. A careful clinical examination and simple bedside autonomic tests can confirm the diagnosis. |
| doi_str_mv | 10.1016/j.jocn.2005.11.041 |
| format | Article |
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Dilute pilocarpine (0.1%) instillation in both eyes revealed parasympathetic denervation hypersensitivity. There was evidence of cardiac dysautonomia in the form of a decrease in heart rate variability with deep breathing and an abnormal Valsalva response. A thermoregulatory sweat test showed the presence of sweating in the right cheek, neck and upper one-third of the left arm and shoulder only. Sympathetic skin responses were absent in the affected segments of the upper limb. Ross syndrome is a degenerative disorder that progressively involves different fibre populations, starting with autonomic fibres and then involving the unmyelinated and myelinated sensory fibres. A careful clinical examination and simple bedside autonomic tests can confirm the diagnosis.</description><identifier>ISSN: 0967-5868</identifier><identifier>EISSN: 1532-2653</identifier><identifier>DOI: 10.1016/j.jocn.2005.11.041</identifier><identifier>PMID: 17070054</identifier><language>eng</language><publisher>Scotland: Elsevier Ltd</publisher><subject>Adult ; Anhidrosis ; Autonomic Nervous System Diseases - complications ; Autonomic Nervous System Diseases - diagnosis ; Blood Pressure - drug effects ; Humans ; Hypohidrosis - diagnosis ; Hypohidrosis - etiology ; Male ; Miotics ; Neural Conduction ; Neurology ; Pilocarpine ; Pupil - physiology ; Reflex, Abnormal - physiology ; Ross syndrome ; Syndrome ; Tonic pupils</subject><ispartof>Journal of clinical neuroscience, 2007-01, Vol.14 (1), p.94-96</ispartof><rights>Elsevier Ltd</rights><rights>2006 Elsevier Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c409t-1333143c899865f163bd891317b3c850afc912abc56b21a90a7319efe1b30f003</citedby><cites>FETCH-LOGICAL-c409t-1333143c899865f163bd891317b3c850afc912abc56b21a90a7319efe1b30f003</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jocn.2005.11.041$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,778,782,3539,27911,27912,45982</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17070054$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chemmanam, Thomas</creatorcontrib><creatorcontrib>Pandian, Jeyaraj D</creatorcontrib><creatorcontrib>Kadyan, Randhir S</creatorcontrib><creatorcontrib>Bhatti, S.M</creatorcontrib><title>Anhidrosis: A clue to an underlying autonomic disorder</title><title>Journal of clinical neuroscience</title><addtitle>J Clin Neurosci</addtitle><description>Abstract We describe a patient with Ross syndrome who had the classic triad of segmental anhidrosis, tonic pupils and hyporeflexia. Dilute pilocarpine (0.1%) instillation in both eyes revealed parasympathetic denervation hypersensitivity. There was evidence of cardiac dysautonomia in the form of a decrease in heart rate variability with deep breathing and an abnormal Valsalva response. A thermoregulatory sweat test showed the presence of sweating in the right cheek, neck and upper one-third of the left arm and shoulder only. Sympathetic skin responses were absent in the affected segments of the upper limb. Ross syndrome is a degenerative disorder that progressively involves different fibre populations, starting with autonomic fibres and then involving the unmyelinated and myelinated sensory fibres. A careful clinical examination and simple bedside autonomic tests can confirm the diagnosis.</description><subject>Adult</subject><subject>Anhidrosis</subject><subject>Autonomic Nervous System Diseases - complications</subject><subject>Autonomic Nervous System Diseases - diagnosis</subject><subject>Blood Pressure - drug effects</subject><subject>Humans</subject><subject>Hypohidrosis - diagnosis</subject><subject>Hypohidrosis - etiology</subject><subject>Male</subject><subject>Miotics</subject><subject>Neural Conduction</subject><subject>Neurology</subject><subject>Pilocarpine</subject><subject>Pupil - physiology</subject><subject>Reflex, Abnormal - physiology</subject><subject>Ross syndrome</subject><subject>Syndrome</subject><subject>Tonic pupils</subject><issn>0967-5868</issn><issn>1532-2653</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kUGL1TAUhYMoznP0D7iQrty13pu0aSMiPIYZFQZczAjuQpreampfMibtwPv3prwHggtXFw7nHLjfYew1QoWA8t1UTcH6igM0FWIFNT5hO2wEL7lsxFO2AyXbsulkd8FepDQBgKoFPGcX2EKbU_WOyb3_6YYYkkvvi31h55WKJRTGF6sfKM5H538UZl2CDwdni8GlELP-kj0bzZzo1flesm831_dXn8vbr5--XO1vS1uDWkoUQmAtbKdUJ5sRpeiHTqHAts9iA2a0CrnpbSN7jkaBaQUqGgl7ASOAuGRvT70PMfxeKS364JKleTaewpq07IRE4HU28pPR5l9SpFE_RHcw8agR9EZLT3qjpTdaGlFnWjn05ty-9gca_kbOeLLhw8lA-cdHR1En68hbGlwku-ghuP_3f_wnbmfnnTXzLzpSmsIafaanUSeuQd9te21zgQSoOf8u_gD3RI5P</recordid><startdate>20070101</startdate><enddate>20070101</enddate><creator>Chemmanam, Thomas</creator><creator>Pandian, Jeyaraj D</creator><creator>Kadyan, Randhir S</creator><creator>Bhatti, S.M</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20070101</creationdate><title>Anhidrosis: A clue to an underlying autonomic disorder</title><author>Chemmanam, Thomas ; Pandian, Jeyaraj D ; Kadyan, Randhir S ; Bhatti, S.M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c409t-1333143c899865f163bd891317b3c850afc912abc56b21a90a7319efe1b30f003</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adult</topic><topic>Anhidrosis</topic><topic>Autonomic Nervous System Diseases - complications</topic><topic>Autonomic Nervous System Diseases - diagnosis</topic><topic>Blood Pressure - drug effects</topic><topic>Humans</topic><topic>Hypohidrosis - diagnosis</topic><topic>Hypohidrosis - etiology</topic><topic>Male</topic><topic>Miotics</topic><topic>Neural Conduction</topic><topic>Neurology</topic><topic>Pilocarpine</topic><topic>Pupil - physiology</topic><topic>Reflex, Abnormal - physiology</topic><topic>Ross syndrome</topic><topic>Syndrome</topic><topic>Tonic pupils</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chemmanam, Thomas</creatorcontrib><creatorcontrib>Pandian, Jeyaraj D</creatorcontrib><creatorcontrib>Kadyan, Randhir S</creatorcontrib><creatorcontrib>Bhatti, S.M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of clinical neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chemmanam, Thomas</au><au>Pandian, Jeyaraj D</au><au>Kadyan, Randhir S</au><au>Bhatti, S.M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anhidrosis: A clue to an underlying autonomic disorder</atitle><jtitle>Journal of clinical neuroscience</jtitle><addtitle>J Clin Neurosci</addtitle><date>2007-01-01</date><risdate>2007</risdate><volume>14</volume><issue>1</issue><spage>94</spage><epage>96</epage><pages>94-96</pages><issn>0967-5868</issn><eissn>1532-2653</eissn><abstract>Abstract We describe a patient with Ross syndrome who had the classic triad of segmental anhidrosis, tonic pupils and hyporeflexia. Dilute pilocarpine (0.1%) instillation in both eyes revealed parasympathetic denervation hypersensitivity. There was evidence of cardiac dysautonomia in the form of a decrease in heart rate variability with deep breathing and an abnormal Valsalva response. A thermoregulatory sweat test showed the presence of sweating in the right cheek, neck and upper one-third of the left arm and shoulder only. Sympathetic skin responses were absent in the affected segments of the upper limb. Ross syndrome is a degenerative disorder that progressively involves different fibre populations, starting with autonomic fibres and then involving the unmyelinated and myelinated sensory fibres. A careful clinical examination and simple bedside autonomic tests can confirm the diagnosis.</abstract><cop>Scotland</cop><pub>Elsevier Ltd</pub><pmid>17070054</pmid><doi>10.1016/j.jocn.2005.11.041</doi><tpages>3</tpages></addata></record> |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Adult Anhidrosis Autonomic Nervous System Diseases - complications Autonomic Nervous System Diseases - diagnosis Blood Pressure - drug effects Humans Hypohidrosis - diagnosis Hypohidrosis - etiology Male Miotics Neural Conduction Neurology Pilocarpine Pupil - physiology Reflex, Abnormal - physiology Ross syndrome Syndrome Tonic pupils |
| title | Anhidrosis: A clue to an underlying autonomic disorder |
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