Diagnostic usefulness of a third-generation anti-cyclic citrulline antibody test in patients with recent-onset polyarthritis
: The high specificity of anti-cyclic citrullinated peptide antibodies (anti-CCP) helps substantially in the diagnosis of rheumatoid arthritis (RA), combined with classical markers such as rheumatoid factor (RF). The recent introduction of third-generation methods (anti-CCP3) for anti-CCP detection...
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| Veröffentlicht in: | Clinical chemistry and laboratory medicine 2007-01, Vol.45 (10), p.1396-1401 |
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| container_title | Clinical chemistry and laboratory medicine |
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| creator | Luis Caro-Oleas, José Fernández-Suárez, Antonio Reneses Cesteros, Sonsoles Porrino, Carmen Núñez-Roldán, Antonio Wichmann Schlipf, Ingeborg |
| description | : The high specificity of anti-cyclic citrullinated peptide antibodies (anti-CCP) helps substantially in the diagnosis of rheumatoid arthritis (RA), combined with classical markers such as rheumatoid factor (RF). The recent introduction of third-generation methods (anti-CCP3) for anti-CCP detection could further improve diagnostic efficiency. The aim of this study was to determinate the diagnostic efficiency (sensitivity and specificity) of anti-CCP using a new anti-CCP3 method and to compare it with the previous second-generation method (anti-CCP2).
: Anti-CCP were studied in sera of 234 patients with recent-onset polyarthritis (ROP) (age ≥16 years; evolution time ≥4 weeks ≤1 year; 2 or more inflamed joints, without drug therapy). After 1 year, 124 patients were diagnosed with RA (American College of Rheumatology criteria). Two ELISAs, an anti-CCP2 and an anti-CCP3, were performed.
: The best sensitivity according to receiver operating characteristic curves was 51.5% and 54.8% for anti-CCP3 and anti-CCP2, with a specificity of 96.2% and 98.1%, respectively (optimal cutoffs 14.2 and 18.7 U/mL). Significant correlations were obtained (p |
| doi_str_mv | 10.1515/CCLM.2007.294 |
| format | Article |
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: Anti-CCP were studied in sera of 234 patients with recent-onset polyarthritis (ROP) (age ≥16 years; evolution time ≥4 weeks ≤1 year; 2 or more inflamed joints, without drug therapy). After 1 year, 124 patients were diagnosed with RA (American College of Rheumatology criteria). Two ELISAs, an anti-CCP2 and an anti-CCP3, were performed.
: The best sensitivity according to receiver operating characteristic curves was 51.5% and 54.8% for anti-CCP3 and anti-CCP2, with a specificity of 96.2% and 98.1%, respectively (optimal cutoffs 14.2 and 18.7 U/mL). Significant correlations were obtained (p<0.001) when the methods were compared to each other and to RF.
: Testing with both types of anti-CCP kit is highly specific for the presence of RA. In our ROP group, anti-CCP2 and anti-CCP3 exhibited similar diagnostic efficiency.
Clin Chem Lab Med 2007;45:1396–401.</description><identifier>ISSN: 1434-6621</identifier><identifier>EISSN: 1437-4331</identifier><identifier>DOI: 10.1515/CCLM.2007.294</identifier><identifier>PMID: 17924851</identifier><language>eng</language><publisher>Berlin: Walter de Gruyter</publisher><subject>Adult ; anti-cyclic citrullinated peptide antibodies (anti-CCP) ; Arthritis - diagnosis ; Arthritis - immunology ; Autoantibodies - blood ; Biological and medical sciences ; Biomarkers - blood ; Enzyme-Linked Immunosorbent Assay ; Female ; General aspects ; Humans ; Investigative techniques, diagnostic techniques (general aspects) ; Male ; Medical sciences ; Middle Aged ; Peptides, Cyclic - immunology ; rheumatoid arthritis ; rheumatoid factor ; Rheumatoid Factor - blood ; Sensitivity and Specificity ; third-generation anti-CCP ELISA</subject><ispartof>Clinical chemistry and laboratory medicine, 2007-01, Vol.45 (10), p.1396-1401</ispartof><rights>2007 by Walter de Gruyter Berlin New York</rights><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-c9f843ee9e2b5254aaf5ed10395aa8154e6cb33616af422166fb5681a59b92c93</citedby><cites>FETCH-LOGICAL-c375t-c9f843ee9e2b5254aaf5ed10395aa8154e6cb33616af422166fb5681a59b92c93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.degruyter.com/document/doi/10.1515/CCLM.2007.294/pdf$$EPDF$$P50$$Gwalterdegruyter$$H</linktopdf><linktohtml>$$Uhttps://www.degruyter.com/document/doi/10.1515/CCLM.2007.294/html$$EHTML$$P50$$Gwalterdegruyter$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,66497,68281</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19204640$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17924851$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Luis Caro-Oleas, José</creatorcontrib><creatorcontrib>Fernández-Suárez, Antonio</creatorcontrib><creatorcontrib>Reneses Cesteros, Sonsoles</creatorcontrib><creatorcontrib>Porrino, Carmen</creatorcontrib><creatorcontrib>Núñez-Roldán, Antonio</creatorcontrib><creatorcontrib>Wichmann Schlipf, Ingeborg</creatorcontrib><title>Diagnostic usefulness of a third-generation anti-cyclic citrulline antibody test in patients with recent-onset polyarthritis</title><title>Clinical chemistry and laboratory medicine</title><addtitle>Clin Chem Lab Med</addtitle><description>: The high specificity of anti-cyclic citrullinated peptide antibodies (anti-CCP) helps substantially in the diagnosis of rheumatoid arthritis (RA), combined with classical markers such as rheumatoid factor (RF). The recent introduction of third-generation methods (anti-CCP3) for anti-CCP detection could further improve diagnostic efficiency. The aim of this study was to determinate the diagnostic efficiency (sensitivity and specificity) of anti-CCP using a new anti-CCP3 method and to compare it with the previous second-generation method (anti-CCP2).
: Anti-CCP were studied in sera of 234 patients with recent-onset polyarthritis (ROP) (age ≥16 years; evolution time ≥4 weeks ≤1 year; 2 or more inflamed joints, without drug therapy). After 1 year, 124 patients were diagnosed with RA (American College of Rheumatology criteria). Two ELISAs, an anti-CCP2 and an anti-CCP3, were performed.
: The best sensitivity according to receiver operating characteristic curves was 51.5% and 54.8% for anti-CCP3 and anti-CCP2, with a specificity of 96.2% and 98.1%, respectively (optimal cutoffs 14.2 and 18.7 U/mL). Significant correlations were obtained (p<0.001) when the methods were compared to each other and to RF.
: Testing with both types of anti-CCP kit is highly specific for the presence of RA. In our ROP group, anti-CCP2 and anti-CCP3 exhibited similar diagnostic efficiency.
Clin Chem Lab Med 2007;45:1396–401.</description><subject>Adult</subject><subject>anti-cyclic citrullinated peptide antibodies (anti-CCP)</subject><subject>Arthritis - diagnosis</subject><subject>Arthritis - immunology</subject><subject>Autoantibodies - blood</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Female</subject><subject>General aspects</subject><subject>Humans</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Peptides, Cyclic - immunology</subject><subject>rheumatoid arthritis</subject><subject>rheumatoid factor</subject><subject>Rheumatoid Factor - blood</subject><subject>Sensitivity and Specificity</subject><subject>third-generation anti-CCP ELISA</subject><issn>1434-6621</issn><issn>1437-4331</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpt0L1vEzEYwOETAtEPGFmRF9gc_H3ngQEFKEipupT55PO9l7hy7GD7VJ3EH1-nidSFya-tR6-sX9N8oGRFJZVf1uvN7YoR0q6YFq-aSyp4iwXn9PXzLLBSjF40Vzk_EEKlFO3b5oK2molO0svm33dntiHm4iyaM0yzD5AzihMyqOxcGvEWAiRTXAzIhOKwXayv2LqSZu9dgOfnIY4LKpALcgEdKodQMnp0ZYcS2HrBMWQo6BD9YlLZJVdcfte8mYzP8P58Xjd_fv64X__Cm7ub3-tvG2x5Kwu2euoEB9DABsmkMGaSMFLCtTSmo1KAsgPniiozCcaoUtMgVUeN1INmVvPr5vNp7yHFv3P9ZL932YL3JkCcc686rohmrEJ8gjbFnBNM_SG5vUlLT0l_zN0fc_fH3H3NXf3H8-J52MP4os99K_h0BiZb46dkgnX5xWlGhBKkuq8n92h8gTTCNs1LHfqHOKdQ2_z_A0JSQrlW_AmFy54R</recordid><startdate>20070101</startdate><enddate>20070101</enddate><creator>Luis Caro-Oleas, José</creator><creator>Fernández-Suárez, Antonio</creator><creator>Reneses Cesteros, Sonsoles</creator><creator>Porrino, Carmen</creator><creator>Núñez-Roldán, Antonio</creator><creator>Wichmann Schlipf, Ingeborg</creator><general>Walter de Gruyter</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20070101</creationdate><title>Diagnostic usefulness of a third-generation anti-cyclic citrulline antibody test in patients with recent-onset polyarthritis</title><author>Luis Caro-Oleas, José ; Fernández-Suárez, Antonio ; Reneses Cesteros, Sonsoles ; Porrino, Carmen ; Núñez-Roldán, Antonio ; Wichmann Schlipf, Ingeborg</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-c9f843ee9e2b5254aaf5ed10395aa8154e6cb33616af422166fb5681a59b92c93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adult</topic><topic>anti-cyclic citrullinated peptide antibodies (anti-CCP)</topic><topic>Arthritis - diagnosis</topic><topic>Arthritis - immunology</topic><topic>Autoantibodies - blood</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - blood</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Female</topic><topic>General aspects</topic><topic>Humans</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Peptides, Cyclic - immunology</topic><topic>rheumatoid arthritis</topic><topic>rheumatoid factor</topic><topic>Rheumatoid Factor - blood</topic><topic>Sensitivity and Specificity</topic><topic>third-generation anti-CCP ELISA</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Luis Caro-Oleas, José</creatorcontrib><creatorcontrib>Fernández-Suárez, Antonio</creatorcontrib><creatorcontrib>Reneses Cesteros, Sonsoles</creatorcontrib><creatorcontrib>Porrino, Carmen</creatorcontrib><creatorcontrib>Núñez-Roldán, Antonio</creatorcontrib><creatorcontrib>Wichmann Schlipf, Ingeborg</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical chemistry and laboratory medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Luis Caro-Oleas, José</au><au>Fernández-Suárez, Antonio</au><au>Reneses Cesteros, Sonsoles</au><au>Porrino, Carmen</au><au>Núñez-Roldán, Antonio</au><au>Wichmann Schlipf, Ingeborg</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Diagnostic usefulness of a third-generation anti-cyclic citrulline antibody test in patients with recent-onset polyarthritis</atitle><jtitle>Clinical chemistry and laboratory medicine</jtitle><addtitle>Clin Chem Lab Med</addtitle><date>2007-01-01</date><risdate>2007</risdate><volume>45</volume><issue>10</issue><spage>1396</spage><epage>1401</epage><pages>1396-1401</pages><issn>1434-6621</issn><eissn>1437-4331</eissn><abstract>: The high specificity of anti-cyclic citrullinated peptide antibodies (anti-CCP) helps substantially in the diagnosis of rheumatoid arthritis (RA), combined with classical markers such as rheumatoid factor (RF). The recent introduction of third-generation methods (anti-CCP3) for anti-CCP detection could further improve diagnostic efficiency. The aim of this study was to determinate the diagnostic efficiency (sensitivity and specificity) of anti-CCP using a new anti-CCP3 method and to compare it with the previous second-generation method (anti-CCP2).
: Anti-CCP were studied in sera of 234 patients with recent-onset polyarthritis (ROP) (age ≥16 years; evolution time ≥4 weeks ≤1 year; 2 or more inflamed joints, without drug therapy). After 1 year, 124 patients were diagnosed with RA (American College of Rheumatology criteria). Two ELISAs, an anti-CCP2 and an anti-CCP3, were performed.
: The best sensitivity according to receiver operating characteristic curves was 51.5% and 54.8% for anti-CCP3 and anti-CCP2, with a specificity of 96.2% and 98.1%, respectively (optimal cutoffs 14.2 and 18.7 U/mL). Significant correlations were obtained (p<0.001) when the methods were compared to each other and to RF.
: Testing with both types of anti-CCP kit is highly specific for the presence of RA. In our ROP group, anti-CCP2 and anti-CCP3 exhibited similar diagnostic efficiency.
Clin Chem Lab Med 2007;45:1396–401.</abstract><cop>Berlin</cop><cop>New York, NY</cop><pub>Walter de Gruyter</pub><pmid>17924851</pmid><doi>10.1515/CCLM.2007.294</doi><tpages>6</tpages></addata></record> |
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| ispartof | Clinical chemistry and laboratory medicine, 2007-01, Vol.45 (10), p.1396-1401 |
| issn | 1434-6621 1437-4331 |
| language | eng |
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| source | MEDLINE; De Gruyter journals |
| subjects | Adult anti-cyclic citrullinated peptide antibodies (anti-CCP) Arthritis - diagnosis Arthritis - immunology Autoantibodies - blood Biological and medical sciences Biomarkers - blood Enzyme-Linked Immunosorbent Assay Female General aspects Humans Investigative techniques, diagnostic techniques (general aspects) Male Medical sciences Middle Aged Peptides, Cyclic - immunology rheumatoid arthritis rheumatoid factor Rheumatoid Factor - blood Sensitivity and Specificity third-generation anti-CCP ELISA |
| title | Diagnostic usefulness of a third-generation anti-cyclic citrulline antibody test in patients with recent-onset polyarthritis |
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