Molecular oxygen (a substrate of the cyclooxygenase reaction) in the kinetic mechanism of the bifunctional enzyme prostaglandin-H-synthase

Prostaglandin-H-synthase is a bifunctional enzyme catalyzing conversion of arachidonic acid into prostaglandin H2 as a result of cyclooxygenase and peroxidase reactions. The dependence of the rate of the cyclooxygenase reaction on oxygen concentration in the absence and in the presence of electron d...

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Veröffentlicht in:	Biochemistry (Moscow) 2007-09, Vol.72 (9), p.944-953
Hauptverfasser:	Filimonov, I S, Vrzheshch, P V
Format:	Artikel
Sprache:	eng
Schlagworte:	Arachidonic acid Arachidonic Acid - metabolism Chemical properties Chemical reactions Cyclooxygenases Electrons Enzymes Kinetics Measurement Models, Biological Molecular biology Oxidation-Reduction Oxygen Oxygen - metabolism Prostaglandin-Endoperoxide Synthases - metabolism Prostaglandins Prostaglandins G - metabolism
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