A Comparison of Tissue-Engineered Hyaluronic Acid Dermal Matrices in a Human Wound Model
The derivatives of hyaluronic acid (hyaluronan) have been extensively studied in the field of tissue engineering. Several forms of the material are available (benzyl esters of hyaluronic acid, HYAFF ® ), with differing degradation profiles. This study compared 2 such products used for dermal regener...
Gespeichert in:
| Veröffentlicht in: | Tissue engineering 2006-10, Vol.12 (10), p.2985-2995 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 2995 |
|---|---|
| container_issue | 10 |
| container_start_page | 2985 |
| container_title | Tissue engineering |
| container_volume | 12 |
| creator | Price, Richard D. Das-Gupta, Victoria Leigh, Irene M. Navsaria, Harshad A. |
| description | The derivatives of hyaluronic acid (hyaluronan) have been extensively studied in the field of tissue
engineering. Several forms of the material are available (benzyl esters of hyaluronic acid, HYAFF
®
),
with differing degradation profiles. This study compared 2 such products used for dermal regeneration
(HYAFF p80 and HYAFF p100, the partial and total benzyl ester of hyaluronan, respectively), in a
human model. In a prospective, randomized, controlled trial, 20 tattoos were tangentially excised and 1 of
2 hyaluronic acid-derived dermal matrices were applied to the wound bed. The partial ester was changed
after 1 week and the total ester was kept for 2 weeks. After 2 weeks, cultured epidermal autograft was
applied using the Laserskin
®
method. Wounds were subsequently assessed by several modalities and by
such features as rate of epithelialization, wound contraction, and histologic and immunohistologic appearances.
Subtle differences were seen between the 2 groups, indicating that the total ester, which
showed better clinical performance, could be used, especially in burns. This has the advantage of a single
application for a 2-week period, rather than the comparison material, a partial ester, which requires
weekly changing and degrades faster. Further, the method of epidermal grafting with a dermal substitute
shows excellent results and adds to the armory for the treatment of both chronic and acute wounds. |
| doi_str_mv | 10.1089/ten.2006.12.2985 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_68360404</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>68360404</sourcerecordid><originalsourceid>FETCH-LOGICAL-c394t-6642b0b623be61e2afe35e0d11f5daba5e5a5939ce26fa1614cc4222f6883cf83</originalsourceid><addsrcrecordid>eNqFkUFr3DAQRkVJaJJt7j0VkUNudiTZGlvHZZN0C1lySWhuQpbHRcGWtpJ9yL-PzS4tpIeeZhje98HwCPnKWc5ZrW5G9LlgDHIucqFq-YmccymrrAbFTuadVZAVolJn5CKlV8aYlLz6TM54JXkNAOfkZU03Ydib6FLwNHT0yaU0YXbnfzmPGLGl2zfTTzF4Z-naupbeYhxMT3dmjM5ios5TQ7fTYDz9GSbf0l1osf9CTjvTJ7w8zhV5vr972myzh8fvPzbrh8wWqhwzgFI0rAFRNAgchemwkMhazjvZmsZIlEaqQlkU0BkOvLS2FEJ0UNeF7epiRa4PvfsYfk-YRj24ZLHvjccwJQ11Aaxk5X9BrkolRVXN4NUH8DVM0c9PaMElMAVqaWMHyMaQUsRO76MbTHzTnOnFjZ7d6MWN5kIvbubIt2Pv1AzY_g0cZcxAfgCWs_G-d9hgHP-A_zS-A-hLmUs</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>215609694</pqid></control><display><type>article</type><title>A Comparison of Tissue-Engineered Hyaluronic Acid Dermal Matrices in a Human Wound Model</title><source>Mary Ann Liebert Online Subscription</source><source>MEDLINE</source><creator>Price, Richard D. ; Das-Gupta, Victoria ; Leigh, Irene M. ; Navsaria, Harshad A.</creator><creatorcontrib>Price, Richard D. ; Das-Gupta, Victoria ; Leigh, Irene M. ; Navsaria, Harshad A.</creatorcontrib><description>The derivatives of hyaluronic acid (hyaluronan) have been extensively studied in the field of tissue
engineering. Several forms of the material are available (benzyl esters of hyaluronic acid, HYAFF
®
),
with differing degradation profiles. This study compared 2 such products used for dermal regeneration
(HYAFF p80 and HYAFF p100, the partial and total benzyl ester of hyaluronan, respectively), in a
human model. In a prospective, randomized, controlled trial, 20 tattoos were tangentially excised and 1 of
2 hyaluronic acid-derived dermal matrices were applied to the wound bed. The partial ester was changed
after 1 week and the total ester was kept for 2 weeks. After 2 weeks, cultured epidermal autograft was
applied using the Laserskin
®
method. Wounds were subsequently assessed by several modalities and by
such features as rate of epithelialization, wound contraction, and histologic and immunohistologic appearances.
Subtle differences were seen between the 2 groups, indicating that the total ester, which
showed better clinical performance, could be used, especially in burns. This has the advantage of a single
application for a 2-week period, rather than the comparison material, a partial ester, which requires
weekly changing and degrades faster. Further, the method of epidermal grafting with a dermal substitute
shows excellent results and adds to the armory for the treatment of both chronic and acute wounds.</description><identifier>ISSN: 1076-3279</identifier><identifier>EISSN: 1557-8690</identifier><identifier>DOI: 10.1089/ten.2006.12.2985</identifier><identifier>PMID: 17518666</identifier><language>eng</language><publisher>United States: Mary Ann Liebert, Inc</publisher><subject>Acids ; Clinical trials ; Comparative studies ; Female ; Guided Tissue Regeneration - methods ; Humans ; Hyaluronic Acid - administration & dosage ; Male ; Matrix ; Skin, Artificial ; Tissue engineering ; Tissue Engineering - methods ; Treatment Outcome ; Wound Healing - drug effects ; Wound Healing - physiology ; Wounds and Injuries - pathology ; Wounds and Injuries - therapy</subject><ispartof>Tissue engineering, 2006-10, Vol.12 (10), p.2985-2995</ispartof><rights>2006, Mary Ann Liebert, Inc.</rights><rights>(©) Copyright 2006, Mary Ann Liebert, Inc.</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c394t-6642b0b623be61e2afe35e0d11f5daba5e5a5939ce26fa1614cc4222f6883cf83</citedby><cites>FETCH-LOGICAL-c394t-6642b0b623be61e2afe35e0d11f5daba5e5a5939ce26fa1614cc4222f6883cf83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.liebertpub.com/doi/epdf/10.1089/ten.2006.12.2985$$EPDF$$P50$$Gmaryannliebert$$H</linktopdf><linktohtml>$$Uhttps://www.liebertpub.com/doi/full/10.1089/ten.2006.12.2985$$EHTML$$P50$$Gmaryannliebert$$H</linktohtml><link.rule.ids>314,780,784,3042,21723,27924,27925,55291,55303</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17518666$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Price, Richard D.</creatorcontrib><creatorcontrib>Das-Gupta, Victoria</creatorcontrib><creatorcontrib>Leigh, Irene M.</creatorcontrib><creatorcontrib>Navsaria, Harshad A.</creatorcontrib><title>A Comparison of Tissue-Engineered Hyaluronic Acid Dermal Matrices in a Human Wound Model</title><title>Tissue engineering</title><addtitle>Tissue Eng</addtitle><description>The derivatives of hyaluronic acid (hyaluronan) have been extensively studied in the field of tissue
engineering. Several forms of the material are available (benzyl esters of hyaluronic acid, HYAFF
®
),
with differing degradation profiles. This study compared 2 such products used for dermal regeneration
(HYAFF p80 and HYAFF p100, the partial and total benzyl ester of hyaluronan, respectively), in a
human model. In a prospective, randomized, controlled trial, 20 tattoos were tangentially excised and 1 of
2 hyaluronic acid-derived dermal matrices were applied to the wound bed. The partial ester was changed
after 1 week and the total ester was kept for 2 weeks. After 2 weeks, cultured epidermal autograft was
applied using the Laserskin
®
method. Wounds were subsequently assessed by several modalities and by
such features as rate of epithelialization, wound contraction, and histologic and immunohistologic appearances.
Subtle differences were seen between the 2 groups, indicating that the total ester, which
showed better clinical performance, could be used, especially in burns. This has the advantage of a single
application for a 2-week period, rather than the comparison material, a partial ester, which requires
weekly changing and degrades faster. Further, the method of epidermal grafting with a dermal substitute
shows excellent results and adds to the armory for the treatment of both chronic and acute wounds.</description><subject>Acids</subject><subject>Clinical trials</subject><subject>Comparative studies</subject><subject>Female</subject><subject>Guided Tissue Regeneration - methods</subject><subject>Humans</subject><subject>Hyaluronic Acid - administration & dosage</subject><subject>Male</subject><subject>Matrix</subject><subject>Skin, Artificial</subject><subject>Tissue engineering</subject><subject>Tissue Engineering - methods</subject><subject>Treatment Outcome</subject><subject>Wound Healing - drug effects</subject><subject>Wound Healing - physiology</subject><subject>Wounds and Injuries - pathology</subject><subject>Wounds and Injuries - therapy</subject><issn>1076-3279</issn><issn>1557-8690</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkUFr3DAQRkVJaJJt7j0VkUNudiTZGlvHZZN0C1lySWhuQpbHRcGWtpJ9yL-PzS4tpIeeZhje98HwCPnKWc5ZrW5G9LlgDHIucqFq-YmccymrrAbFTuadVZAVolJn5CKlV8aYlLz6TM54JXkNAOfkZU03Ydib6FLwNHT0yaU0YXbnfzmPGLGl2zfTTzF4Z-naupbeYhxMT3dmjM5ios5TQ7fTYDz9GSbf0l1osf9CTjvTJ7w8zhV5vr972myzh8fvPzbrh8wWqhwzgFI0rAFRNAgchemwkMhazjvZmsZIlEaqQlkU0BkOvLS2FEJ0UNeF7epiRa4PvfsYfk-YRj24ZLHvjccwJQ11Aaxk5X9BrkolRVXN4NUH8DVM0c9PaMElMAVqaWMHyMaQUsRO76MbTHzTnOnFjZ7d6MWN5kIvbubIt2Pv1AzY_g0cZcxAfgCWs_G-d9hgHP-A_zS-A-hLmUs</recordid><startdate>20061001</startdate><enddate>20061001</enddate><creator>Price, Richard D.</creator><creator>Das-Gupta, Victoria</creator><creator>Leigh, Irene M.</creator><creator>Navsaria, Harshad A.</creator><general>Mary Ann Liebert, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20061001</creationdate><title>A Comparison of Tissue-Engineered Hyaluronic Acid Dermal Matrices in a Human Wound Model</title><author>Price, Richard D. ; Das-Gupta, Victoria ; Leigh, Irene M. ; Navsaria, Harshad A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c394t-6642b0b623be61e2afe35e0d11f5daba5e5a5939ce26fa1614cc4222f6883cf83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Acids</topic><topic>Clinical trials</topic><topic>Comparative studies</topic><topic>Female</topic><topic>Guided Tissue Regeneration - methods</topic><topic>Humans</topic><topic>Hyaluronic Acid - administration & dosage</topic><topic>Male</topic><topic>Matrix</topic><topic>Skin, Artificial</topic><topic>Tissue engineering</topic><topic>Tissue Engineering - methods</topic><topic>Treatment Outcome</topic><topic>Wound Healing - drug effects</topic><topic>Wound Healing - physiology</topic><topic>Wounds and Injuries - pathology</topic><topic>Wounds and Injuries - therapy</topic><toplevel>online_resources</toplevel><creatorcontrib>Price, Richard D.</creatorcontrib><creatorcontrib>Das-Gupta, Victoria</creatorcontrib><creatorcontrib>Leigh, Irene M.</creatorcontrib><creatorcontrib>Navsaria, Harshad A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Tissue engineering</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Price, Richard D.</au><au>Das-Gupta, Victoria</au><au>Leigh, Irene M.</au><au>Navsaria, Harshad A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Comparison of Tissue-Engineered Hyaluronic Acid Dermal Matrices in a Human Wound Model</atitle><jtitle>Tissue engineering</jtitle><addtitle>Tissue Eng</addtitle><date>2006-10-01</date><risdate>2006</risdate><volume>12</volume><issue>10</issue><spage>2985</spage><epage>2995</epage><pages>2985-2995</pages><issn>1076-3279</issn><eissn>1557-8690</eissn><abstract>The derivatives of hyaluronic acid (hyaluronan) have been extensively studied in the field of tissue
engineering. Several forms of the material are available (benzyl esters of hyaluronic acid, HYAFF
®
),
with differing degradation profiles. This study compared 2 such products used for dermal regeneration
(HYAFF p80 and HYAFF p100, the partial and total benzyl ester of hyaluronan, respectively), in a
human model. In a prospective, randomized, controlled trial, 20 tattoos were tangentially excised and 1 of
2 hyaluronic acid-derived dermal matrices were applied to the wound bed. The partial ester was changed
after 1 week and the total ester was kept for 2 weeks. After 2 weeks, cultured epidermal autograft was
applied using the Laserskin
®
method. Wounds were subsequently assessed by several modalities and by
such features as rate of epithelialization, wound contraction, and histologic and immunohistologic appearances.
Subtle differences were seen between the 2 groups, indicating that the total ester, which
showed better clinical performance, could be used, especially in burns. This has the advantage of a single
application for a 2-week period, rather than the comparison material, a partial ester, which requires
weekly changing and degrades faster. Further, the method of epidermal grafting with a dermal substitute
shows excellent results and adds to the armory for the treatment of both chronic and acute wounds.</abstract><cop>United States</cop><pub>Mary Ann Liebert, Inc</pub><pmid>17518666</pmid><doi>10.1089/ten.2006.12.2985</doi><tpages>11</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1076-3279 |
| ispartof | Tissue engineering, 2006-10, Vol.12 (10), p.2985-2995 |
| issn | 1076-3279 1557-8690 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_68360404 |
| source | Mary Ann Liebert Online Subscription; MEDLINE |
| subjects | Acids Clinical trials Comparative studies Female Guided Tissue Regeneration - methods Humans Hyaluronic Acid - administration & dosage Male Matrix Skin, Artificial Tissue engineering Tissue Engineering - methods Treatment Outcome Wound Healing - drug effects Wound Healing - physiology Wounds and Injuries - pathology Wounds and Injuries - therapy |
| title | A Comparison of Tissue-Engineered Hyaluronic Acid Dermal Matrices in a Human Wound Model |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-29T09%3A21%3A59IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20Comparison%20of%20Tissue-Engineered%20Hyaluronic%20Acid%20Dermal%20Matrices%20in%20a%20Human%20Wound%20Model&rft.jtitle=Tissue%20engineering&rft.au=Price,%20Richard%20D.&rft.date=2006-10-01&rft.volume=12&rft.issue=10&rft.spage=2985&rft.epage=2995&rft.pages=2985-2995&rft.issn=1076-3279&rft.eissn=1557-8690&rft_id=info:doi/10.1089/ten.2006.12.2985&rft_dat=%3Cproquest_cross%3E68360404%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=215609694&rft_id=info:pmid/17518666&rfr_iscdi=true |