Ferrophilic Characteristics of Vibrio vulnificus and Potential Usefulness of Iron Chelation Therapy
We determined the ferrophilic characteristics of Vibrio vulnificus to evaluate the potential usefulness of iron chelation therapy for the prevention of V. vulnificus infection. Readily available non–transferrin-bound iron (NTBI) is required for the initiation of V. vulnificus growth under in vitro i...
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| Veröffentlicht in: | The Journal of infectious diseases 2007-01, Vol.195 (1), p.90-98 |
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| container_title | The Journal of infectious diseases |
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| creator | Kim, Choon-Mee Park, Ra-Young Choi, Mi-Hwa Sun, Hui-Yu Shin, Sung-Heui |
| description | We determined the ferrophilic characteristics of Vibrio vulnificus to evaluate the potential usefulness of iron chelation therapy for the prevention of V. vulnificus infection. Readily available non–transferrin-bound iron (NTBI) is required for the initiation of V. vulnificus growth under in vitro iron-limited conditions and human ex vivo conditions. NTBI aided efficient transferrin-bound iron (TBI) use by V. vulnificus and the vulnibactin-mediated iron-uptake system was expressed after bacterial growth had been started by NTBI. V. vulnificus required higher NTBI levels for the initiation of growth, produced siderophores at lower levels, and used TBI less efficiently than other bacteria. In addition, the growth of V. vulnificus was inhibited by deferiprone, a clinically available iron chelator. These results show that V. vulnificus is a ferrophilic bacterium that requires higher NTBI levels than other pathogens and that iron chelation therapy might be an effective means of preventing the in vivo growth of V. vulnificus in susceptible patients |
| doi_str_mv | 10.1086/509822 |
| format | Article |
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Readily available non–transferrin-bound iron (NTBI) is required for the initiation of V. vulnificus growth under in vitro iron-limited conditions and human ex vivo conditions. NTBI aided efficient transferrin-bound iron (TBI) use by V. vulnificus and the vulnibactin-mediated iron-uptake system was expressed after bacterial growth had been started by NTBI. V. vulnificus required higher NTBI levels for the initiation of growth, produced siderophores at lower levels, and used TBI less efficiently than other bacteria. In addition, the growth of V. vulnificus was inhibited by deferiprone, a clinically available iron chelator. These results show that V. vulnificus is a ferrophilic bacterium that requires higher NTBI levels than other pathogens and that iron chelation therapy might be an effective means of preventing the in vivo growth of V. vulnificus in susceptible patients</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1086/509822</identifier><identifier>PMID: 17152012</identifier><identifier>CODEN: JIDIAQ</identifier><language>eng</language><publisher>Chicago, IL: The University of Chicago Press</publisher><subject>Bacteria ; Bacterial Proteins ; Bacteriology ; Biological and medical sciences ; Escherichia coli ; Ferric Compounds - metabolism ; Fundamental and applied biological sciences. Psychology ; Gels ; Growth, nutrition, cell differenciation ; Infections ; Iron ; Iron - metabolism ; Iron Chelating Agents - therapeutic use ; Microbiology ; Optical density ; Repressor Proteins ; Sepsis ; Siderophores ; Transferrin - metabolism ; Transferrins ; Vibrio vulnificus ; Vibrio vulnificus - enzymology ; Vibrio vulnificus - growth & development ; Vibrio vulnificus - metabolism</subject><ispartof>The Journal of infectious diseases, 2007-01, Vol.195 (1), p.90-98</ispartof><rights>Copyright 2006 Infectious Diseases Society of America</rights><rights>2007 by the Infectious Diseases Society of America 2007</rights><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c424t-549de79491bc6c91cc0da00e05696f13e2aa24c326844508f7a8b141dd9163933</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/30087454$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/30087454$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>315,782,786,805,4026,27930,27931,27932,58024,58257</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18384677$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17152012$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Choon-Mee</creatorcontrib><creatorcontrib>Park, Ra-Young</creatorcontrib><creatorcontrib>Choi, Mi-Hwa</creatorcontrib><creatorcontrib>Sun, Hui-Yu</creatorcontrib><creatorcontrib>Shin, Sung-Heui</creatorcontrib><title>Ferrophilic Characteristics of Vibrio vulnificus and Potential Usefulness of Iron Chelation Therapy</title><title>The Journal of infectious diseases</title><addtitle>The Journal of Infectious Diseases</addtitle><addtitle>The Journal of Infectious Diseases</addtitle><description>We determined the ferrophilic characteristics of Vibrio vulnificus to evaluate the potential usefulness of iron chelation therapy for the prevention of V. vulnificus infection. Readily available non–transferrin-bound iron (NTBI) is required for the initiation of V. vulnificus growth under in vitro iron-limited conditions and human ex vivo conditions. NTBI aided efficient transferrin-bound iron (TBI) use by V. vulnificus and the vulnibactin-mediated iron-uptake system was expressed after bacterial growth had been started by NTBI. V. vulnificus required higher NTBI levels for the initiation of growth, produced siderophores at lower levels, and used TBI less efficiently than other bacteria. In addition, the growth of V. vulnificus was inhibited by deferiprone, a clinically available iron chelator. These results show that V. vulnificus is a ferrophilic bacterium that requires higher NTBI levels than other pathogens and that iron chelation therapy might be an effective means of preventing the in vivo growth of V. vulnificus in susceptible patients</description><subject>Bacteria</subject><subject>Bacterial Proteins</subject><subject>Bacteriology</subject><subject>Biological and medical sciences</subject><subject>Escherichia coli</subject><subject>Ferric Compounds - metabolism</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gels</subject><subject>Growth, nutrition, cell differenciation</subject><subject>Infections</subject><subject>Iron</subject><subject>Iron - metabolism</subject><subject>Iron Chelating Agents - therapeutic use</subject><subject>Microbiology</subject><subject>Optical density</subject><subject>Repressor Proteins</subject><subject>Sepsis</subject><subject>Siderophores</subject><subject>Transferrin - metabolism</subject><subject>Transferrins</subject><subject>Vibrio vulnificus</subject><subject>Vibrio vulnificus - enzymology</subject><subject>Vibrio vulnificus - growth & development</subject><subject>Vibrio vulnificus - metabolism</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0l1rFDEUBuAgil2r_gNlvNC70XPynUtZbLdQULAV8SZkMxk2dXYyTWbE_nunnaX1RrxK4H14A-eEkJcI7xG0_CDAaEofkRUKpmopkT0mKwBKa9TGHJFnpVwBAGdSPSVHqFBQQLoi_iTknIZd7KKv1juXnR9DjmWMvlSprb7FbY6p-jV1fWyjn0rl-qb6ksbQj9F11WUJ7ZyFcqfPcurnltC5Mc63i13Ibrh5Tp60rivhxeE8Jpcnny7Wm_r88-nZ-uN57TnlYy24aYIy3ODWS2_Qe2gcQAAhjWyRBeoc5Z5RqTkXoFvl9BY5No1ByQxjx-Td0jvkdD2FMtp9LD50netDmoqVmklgGv8L0QikHP-CPqdScmjtkOPe5RuLYG_nbpe5z_D1oXHa7kPzwA6DnsHbA3DFu67NrvexPDjNNJdKze7N4tI0_PuxV4u5KmPK94oBaMUFn_N6yec1ht_3ucs_rVRMCbv5_sOy-aOwzddTi-wPU8urng</recordid><startdate>20070101</startdate><enddate>20070101</enddate><creator>Kim, Choon-Mee</creator><creator>Park, Ra-Young</creator><creator>Choi, Mi-Hwa</creator><creator>Sun, Hui-Yu</creator><creator>Shin, Sung-Heui</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>C1K</scope><scope>F1W</scope><scope>H97</scope><scope>L.G</scope><scope>7X8</scope></search><sort><creationdate>20070101</creationdate><title>Ferrophilic Characteristics of Vibrio vulnificus and Potential Usefulness of Iron Chelation Therapy</title><author>Kim, Choon-Mee ; Park, Ra-Young ; Choi, Mi-Hwa ; Sun, Hui-Yu ; Shin, Sung-Heui</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c424t-549de79491bc6c91cc0da00e05696f13e2aa24c326844508f7a8b141dd9163933</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Bacteria</topic><topic>Bacterial Proteins</topic><topic>Bacteriology</topic><topic>Biological and medical sciences</topic><topic>Escherichia coli</topic><topic>Ferric Compounds - metabolism</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gels</topic><topic>Growth, nutrition, cell differenciation</topic><topic>Infections</topic><topic>Iron</topic><topic>Iron - metabolism</topic><topic>Iron Chelating Agents - therapeutic use</topic><topic>Microbiology</topic><topic>Optical density</topic><topic>Repressor Proteins</topic><topic>Sepsis</topic><topic>Siderophores</topic><topic>Transferrin - metabolism</topic><topic>Transferrins</topic><topic>Vibrio vulnificus</topic><topic>Vibrio vulnificus - enzymology</topic><topic>Vibrio vulnificus - growth & development</topic><topic>Vibrio vulnificus - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Choon-Mee</creatorcontrib><creatorcontrib>Park, Ra-Young</creatorcontrib><creatorcontrib>Choi, Mi-Hwa</creatorcontrib><creatorcontrib>Sun, Hui-Yu</creatorcontrib><creatorcontrib>Shin, Sung-Heui</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 3: Aquatic Pollution & Environmental Quality</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Choon-Mee</au><au>Park, Ra-Young</au><au>Choi, Mi-Hwa</au><au>Sun, Hui-Yu</au><au>Shin, Sung-Heui</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ferrophilic Characteristics of Vibrio vulnificus and Potential Usefulness of Iron Chelation Therapy</atitle><jtitle>The Journal of infectious diseases</jtitle><stitle>The Journal of Infectious Diseases</stitle><addtitle>The Journal of Infectious Diseases</addtitle><date>2007-01-01</date><risdate>2007</risdate><volume>195</volume><issue>1</issue><spage>90</spage><epage>98</epage><pages>90-98</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><coden>JIDIAQ</coden><abstract>We determined the ferrophilic characteristics of Vibrio vulnificus to evaluate the potential usefulness of iron chelation therapy for the prevention of V. vulnificus infection. Readily available non–transferrin-bound iron (NTBI) is required for the initiation of V. vulnificus growth under in vitro iron-limited conditions and human ex vivo conditions. NTBI aided efficient transferrin-bound iron (TBI) use by V. vulnificus and the vulnibactin-mediated iron-uptake system was expressed after bacterial growth had been started by NTBI. V. vulnificus required higher NTBI levels for the initiation of growth, produced siderophores at lower levels, and used TBI less efficiently than other bacteria. In addition, the growth of V. vulnificus was inhibited by deferiprone, a clinically available iron chelator. These results show that V. vulnificus is a ferrophilic bacterium that requires higher NTBI levels than other pathogens and that iron chelation therapy might be an effective means of preventing the in vivo growth of V. vulnificus in susceptible patients</abstract><cop>Chicago, IL</cop><pub>The University of Chicago Press</pub><pmid>17152012</pmid><doi>10.1086/509822</doi><tpages>9</tpages></addata></record> |
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| source | MEDLINE; JSTOR Archive Collection A-Z Listing; Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection |
| subjects | Bacteria Bacterial Proteins Bacteriology Biological and medical sciences Escherichia coli Ferric Compounds - metabolism Fundamental and applied biological sciences. Psychology Gels Growth, nutrition, cell differenciation Infections Iron Iron - metabolism Iron Chelating Agents - therapeutic use Microbiology Optical density Repressor Proteins Sepsis Siderophores Transferrin - metabolism Transferrins Vibrio vulnificus Vibrio vulnificus - enzymology Vibrio vulnificus - growth & development Vibrio vulnificus - metabolism |
| title | Ferrophilic Characteristics of Vibrio vulnificus and Potential Usefulness of Iron Chelation Therapy |
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