Association Between Functional Polymorphisms of Renin-Angiotensin System, Left Ventricular Mass, and Geometry Over 4 Years in a Healthy Chinese Population Aged 60 Years and Older
Background. Cross-sectional studies investigated the impact of renin-angiotensin system (RAS) gene polymorphism on left ventricular mass index (LVMI) with conflicting results. We conducted a longitudinal study to investigate the influence of the angiotensin-converting enzyme (ACE) insertion/deletion...
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| container_title | The journals of gerontology. Series A, Biological sciences and medical sciences |
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| creator | Lin, Tsung-Hsien Chiu, Herng-Chia Lee, Ya-Ting Su, Ho-Ming Voon, Wen-Chol Liu, Hong-Wen Lai, Wen-Ter Sheu, Sheng-Hsiung |
| description | Background. Cross-sectional studies investigated the impact of renin-angiotensin system (RAS) gene polymorphism on left ventricular mass index (LVMI) with conflicting results. We conducted a longitudinal study to investigate the influence of the angiotensin-converting enzyme (ACE) insertion/deletion (I/D) and angiotensinogen (AGT) M235T and angiotensin II type 1 receptor (AT1R) A1166C gene polymorphisms on the LVMI and geometry. Methods. Of 1500 people screened, 110 nondiabetic normotensive elderly Chinese persons were recruited and received echocardiography at baseline and at the 2nd and 4th year follow-up. No participants had a history of organic heart disease or chronic medication. The gene polymorphisms were analyzed by using polymerase chain reaction. Results. Participant age was 71.9 ± 3.9 years (range 60–81 years). The prevalence of concentric remodeling, eccentric hypertrophy, and concentric hypertrophy was significantly increased as well as LVMI after 4 years (all p |
| doi_str_mv | 10.1093/gerona/62.10.1157 |
| format | Article |
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Cross-sectional studies investigated the impact of renin-angiotensin system (RAS) gene polymorphism on left ventricular mass index (LVMI) with conflicting results. We conducted a longitudinal study to investigate the influence of the angiotensin-converting enzyme (ACE) insertion/deletion (I/D) and angiotensinogen (AGT) M235T and angiotensin II type 1 receptor (AT1R) A1166C gene polymorphisms on the LVMI and geometry. Methods. Of 1500 people screened, 110 nondiabetic normotensive elderly Chinese persons were recruited and received echocardiography at baseline and at the 2nd and 4th year follow-up. No participants had a history of organic heart disease or chronic medication. The gene polymorphisms were analyzed by using polymerase chain reaction. Results. Participant age was 71.9 ± 3.9 years (range 60–81 years). The prevalence of concentric remodeling, eccentric hypertrophy, and concentric hypertrophy was significantly increased as well as LVMI after 4 years (all p <.05). These changes and the magnitude of LVMI increase were significantly higher in participants carrying the ACE D allele than non-D-allele carriers (all p <.05). This association was still significant in multivariate analyses (p ≤.02). A similar analysis showed a borderline significance in the AT1R but not in the AGT gene polymorphism. Conclusions. This longitudinal study showed that the aging process was associated with an increase of LVMI and changes of geometry. The RAS gene polymorphism, especially the ACE D allele, might modulate these changes in the Chinese population. This provides further knowledge that is essential in the assessment of cardiac disease and the determination of the left ventricular structure in older persons.</description><identifier>ISSN: 1079-5006</identifier><identifier>EISSN: 1758-535X</identifier><identifier>DOI: 10.1093/gerona/62.10.1157</identifier><identifier>PMID: 17921431</identifier><language>eng</language><publisher>United States: Oxford University Press</publisher><subject>ACE inhibitors ; Age ; Aged ; Aged, 80 and over ; Aging ; Aging - physiology ; Angiotensinogen - genetics ; Asian Continental Ancestry Group - genetics ; Blood pressure ; Cardiovascular disease ; Cohort Studies ; Deoxyribonucleic acid ; DNA ; Female ; Gerontology ; Heart ; Humans ; Hypertrophy, Left Ventricular - ethnology ; Hypertrophy, Left Ventricular - genetics ; Male ; Middle Aged ; Mortality ; Peptidyl-Dipeptidase A - genetics ; Plasma ; Polymorphism ; Polymorphism, Genetic - genetics ; Receptor, Angiotensin, Type 1 - genetics ; Regression analysis ; Risk factors ; Standard deviation ; Studies ; Taiwan ; Ventricular Remodeling - genetics</subject><ispartof>The journals of gerontology. Series A, Biological sciences and medical sciences, 2007-10, Vol.62 (10), p.1157-1163</ispartof><rights>Copyright Gerontological Society of America, Incorporated Oct 2007</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c407t-1a24b4b0b1754ef7c79e3188dea00ff186070466c64edf54388c05931944a2d63</citedby><cites>FETCH-LOGICAL-c407t-1a24b4b0b1754ef7c79e3188dea00ff186070466c64edf54388c05931944a2d63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17921431$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lin, Tsung-Hsien</creatorcontrib><creatorcontrib>Chiu, Herng-Chia</creatorcontrib><creatorcontrib>Lee, Ya-Ting</creatorcontrib><creatorcontrib>Su, Ho-Ming</creatorcontrib><creatorcontrib>Voon, Wen-Chol</creatorcontrib><creatorcontrib>Liu, Hong-Wen</creatorcontrib><creatorcontrib>Lai, Wen-Ter</creatorcontrib><creatorcontrib>Sheu, Sheng-Hsiung</creatorcontrib><title>Association Between Functional Polymorphisms of Renin-Angiotensin System, Left Ventricular Mass, and Geometry Over 4 Years in a Healthy Chinese Population Aged 60 Years and Older</title><title>The journals of gerontology. Series A, Biological sciences and medical sciences</title><addtitle>J Gerontol A Biol Sci Med Sci</addtitle><description>Background. Cross-sectional studies investigated the impact of renin-angiotensin system (RAS) gene polymorphism on left ventricular mass index (LVMI) with conflicting results. We conducted a longitudinal study to investigate the influence of the angiotensin-converting enzyme (ACE) insertion/deletion (I/D) and angiotensinogen (AGT) M235T and angiotensin II type 1 receptor (AT1R) A1166C gene polymorphisms on the LVMI and geometry. Methods. Of 1500 people screened, 110 nondiabetic normotensive elderly Chinese persons were recruited and received echocardiography at baseline and at the 2nd and 4th year follow-up. No participants had a history of organic heart disease or chronic medication. The gene polymorphisms were analyzed by using polymerase chain reaction. Results. Participant age was 71.9 ± 3.9 years (range 60–81 years). The prevalence of concentric remodeling, eccentric hypertrophy, and concentric hypertrophy was significantly increased as well as LVMI after 4 years (all p <.05). These changes and the magnitude of LVMI increase were significantly higher in participants carrying the ACE D allele than non-D-allele carriers (all p <.05). This association was still significant in multivariate analyses (p ≤.02). A similar analysis showed a borderline significance in the AT1R but not in the AGT gene polymorphism. Conclusions. This longitudinal study showed that the aging process was associated with an increase of LVMI and changes of geometry. The RAS gene polymorphism, especially the ACE D allele, might modulate these changes in the Chinese population. This provides further knowledge that is essential in the assessment of cardiac disease and the determination of the left ventricular structure in older persons.</description><subject>ACE inhibitors</subject><subject>Age</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Aging</subject><subject>Aging - physiology</subject><subject>Angiotensinogen - genetics</subject><subject>Asian Continental Ancestry Group - genetics</subject><subject>Blood pressure</subject><subject>Cardiovascular disease</subject><subject>Cohort Studies</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>Female</subject><subject>Gerontology</subject><subject>Heart</subject><subject>Humans</subject><subject>Hypertrophy, Left Ventricular - ethnology</subject><subject>Hypertrophy, Left Ventricular - genetics</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Peptidyl-Dipeptidase A - genetics</subject><subject>Plasma</subject><subject>Polymorphism</subject><subject>Polymorphism, Genetic - genetics</subject><subject>Receptor, Angiotensin, Type 1 - genetics</subject><subject>Regression analysis</subject><subject>Risk factors</subject><subject>Standard deviation</subject><subject>Studies</subject><subject>Taiwan</subject><subject>Ventricular Remodeling - genetics</subject><issn>1079-5006</issn><issn>1758-535X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkd9u0zAUxiMEYmPwANwgiwuuls2O_yWXpWIrUFQEZRq7sdzkpPVI7GI7G3ktnhB3rUDCN7aOf993js6XZS8JPiO4oudr8M7qc1Gc7SqEy0fZMZG8zDnl14_TG8sq5xiLo-xZCLd4d3jxNDsisioIo-Q4-z0JwdVGR-MsegvxHsCii8HWu4Lu0GfXjb3z240JfUCuRV_AGptP7Nq4CDYYi76OIUJ_iubQRnQFNnpTD5326JMO4RRp26BLcD1EP6LFHXjE0HfQPqCk1WgGuoubEU03xkKA1HCbxA_jTNbQIIEP9M5n0TXgn2dPWt0FeHG4T7JvF--W01k-X1y-n07mec2wjDnRBVuxFV6ljTBoZS0roKQsG9AYty0pBZaYCVELBk3LGS3LGvOKkooxXTSCnmRv9r5b734OEKLqTaih67QFNwQlSsqrUvAEvv4PvHWDT9sLqsCpTUWYTBDZQ7V3IXho1dabXvtREax2aap9mkoUD5WUZtK8OhgPqx6af4pDfAnI94BJEfz6-6_9DyUklVzNrm8U_vjhBvPllVrSPxjHrIU</recordid><startdate>20071001</startdate><enddate>20071001</enddate><creator>Lin, Tsung-Hsien</creator><creator>Chiu, Herng-Chia</creator><creator>Lee, Ya-Ting</creator><creator>Su, Ho-Ming</creator><creator>Voon, Wen-Chol</creator><creator>Liu, Hong-Wen</creator><creator>Lai, Wen-Ter</creator><creator>Sheu, Sheng-Hsiung</creator><general>Oxford University Press</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20071001</creationdate><title>Association Between Functional Polymorphisms of Renin-Angiotensin System, Left Ventricular Mass, and Geometry Over 4 Years in a Healthy Chinese Population Aged 60 Years and Older</title><author>Lin, Tsung-Hsien ; Chiu, Herng-Chia ; Lee, Ya-Ting ; Su, Ho-Ming ; Voon, Wen-Chol ; Liu, Hong-Wen ; Lai, Wen-Ter ; Sheu, Sheng-Hsiung</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c407t-1a24b4b0b1754ef7c79e3188dea00ff186070466c64edf54388c05931944a2d63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>ACE inhibitors</topic><topic>Age</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Aging</topic><topic>Aging - physiology</topic><topic>Angiotensinogen - genetics</topic><topic>Asian Continental Ancestry Group - genetics</topic><topic>Blood pressure</topic><topic>Cardiovascular disease</topic><topic>Cohort Studies</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>Female</topic><topic>Gerontology</topic><topic>Heart</topic><topic>Humans</topic><topic>Hypertrophy, Left Ventricular - ethnology</topic><topic>Hypertrophy, Left Ventricular - genetics</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Peptidyl-Dipeptidase A - genetics</topic><topic>Plasma</topic><topic>Polymorphism</topic><topic>Polymorphism, Genetic - genetics</topic><topic>Receptor, Angiotensin, Type 1 - genetics</topic><topic>Regression analysis</topic><topic>Risk factors</topic><topic>Standard deviation</topic><topic>Studies</topic><topic>Taiwan</topic><topic>Ventricular Remodeling - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lin, Tsung-Hsien</creatorcontrib><creatorcontrib>Chiu, Herng-Chia</creatorcontrib><creatorcontrib>Lee, Ya-Ting</creatorcontrib><creatorcontrib>Su, Ho-Ming</creatorcontrib><creatorcontrib>Voon, Wen-Chol</creatorcontrib><creatorcontrib>Liu, Hong-Wen</creatorcontrib><creatorcontrib>Lai, Wen-Ter</creatorcontrib><creatorcontrib>Sheu, Sheng-Hsiung</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>The journals of gerontology. Series A, Biological sciences and medical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lin, Tsung-Hsien</au><au>Chiu, Herng-Chia</au><au>Lee, Ya-Ting</au><au>Su, Ho-Ming</au><au>Voon, Wen-Chol</au><au>Liu, Hong-Wen</au><au>Lai, Wen-Ter</au><au>Sheu, Sheng-Hsiung</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association Between Functional Polymorphisms of Renin-Angiotensin System, Left Ventricular Mass, and Geometry Over 4 Years in a Healthy Chinese Population Aged 60 Years and Older</atitle><jtitle>The journals of gerontology. Series A, Biological sciences and medical sciences</jtitle><addtitle>J Gerontol A Biol Sci Med Sci</addtitle><date>2007-10-01</date><risdate>2007</risdate><volume>62</volume><issue>10</issue><spage>1157</spage><epage>1163</epage><pages>1157-1163</pages><issn>1079-5006</issn><eissn>1758-535X</eissn><abstract>Background. Cross-sectional studies investigated the impact of renin-angiotensin system (RAS) gene polymorphism on left ventricular mass index (LVMI) with conflicting results. We conducted a longitudinal study to investigate the influence of the angiotensin-converting enzyme (ACE) insertion/deletion (I/D) and angiotensinogen (AGT) M235T and angiotensin II type 1 receptor (AT1R) A1166C gene polymorphisms on the LVMI and geometry. Methods. Of 1500 people screened, 110 nondiabetic normotensive elderly Chinese persons were recruited and received echocardiography at baseline and at the 2nd and 4th year follow-up. No participants had a history of organic heart disease or chronic medication. The gene polymorphisms were analyzed by using polymerase chain reaction. Results. Participant age was 71.9 ± 3.9 years (range 60–81 years). The prevalence of concentric remodeling, eccentric hypertrophy, and concentric hypertrophy was significantly increased as well as LVMI after 4 years (all p <.05). These changes and the magnitude of LVMI increase were significantly higher in participants carrying the ACE D allele than non-D-allele carriers (all p <.05). This association was still significant in multivariate analyses (p ≤.02). A similar analysis showed a borderline significance in the AT1R but not in the AGT gene polymorphism. Conclusions. This longitudinal study showed that the aging process was associated with an increase of LVMI and changes of geometry. The RAS gene polymorphism, especially the ACE D allele, might modulate these changes in the Chinese population. This provides further knowledge that is essential in the assessment of cardiac disease and the determination of the left ventricular structure in older persons.</abstract><cop>United States</cop><pub>Oxford University Press</pub><pmid>17921431</pmid><doi>10.1093/gerona/62.10.1157</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | ACE inhibitors Age Aged Aged, 80 and over Aging Aging - physiology Angiotensinogen - genetics Asian Continental Ancestry Group - genetics Blood pressure Cardiovascular disease Cohort Studies Deoxyribonucleic acid DNA Female Gerontology Heart Humans Hypertrophy, Left Ventricular - ethnology Hypertrophy, Left Ventricular - genetics Male Middle Aged Mortality Peptidyl-Dipeptidase A - genetics Plasma Polymorphism Polymorphism, Genetic - genetics Receptor, Angiotensin, Type 1 - genetics Regression analysis Risk factors Standard deviation Studies Taiwan Ventricular Remodeling - genetics |
| title | Association Between Functional Polymorphisms of Renin-Angiotensin System, Left Ventricular Mass, and Geometry Over 4 Years in a Healthy Chinese Population Aged 60 Years and Older |
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