The effects of JWB1-84-1 on memory-related task performance by amyloid Abeta transgenic mice and by young and aged monkeys

JWB1-84-1 is one of 50 tertiary amine analogs of choline synthesized with expectation that they would be high potency compounds for cytoprotection. As one of the more potent analogs in this regard, JWB1-84-1, a piperazine derivative, was selected for testing as a cognition-enhancing agent. The compo...

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Veröffentlicht in:	Neuropharmacology 2007-10, Vol.53 (5), p.588-600
Hauptverfasser:	Sood, Ajay, Warren Beach, J, Webster, Scott J, Terry, Alvin V, Buccafusco, Jerry J
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging - psychology Amyloid beta-Peptides - genetics Amyloid beta-Peptides - physiology Animals Anxiety - psychology Brain Chemistry - drug effects Darkness Dose-Response Relationship, Drug Female Hand Strength - physiology Light Macaca mulatta Macaca nemestrina Male Maze Learning - drug effects Memory - drug effects Mice Mice, Transgenic Motor Activity - drug effects Neuroprotective Agents - therapeutic use Piperazines - pharmacology Postural Balance - drug effects Psychomotor Performance - drug effects Pyridines - pharmacology
Online-Zugang:	Volltext
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