Design of endoperoxides with anti- Candida activity
Broad antifungal structure–activity relationships governing epoxy-endoperoxides 2 and 3 and their parent endoperoxides 1 are reported. Their inhibitory activity against Candida albicans in conjunction with hemolytic activity and/or growth inhibition of cultured mammalian cells are reported. This inf...
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| Veröffentlicht in: | Bioorganic & medicinal chemistry 2007, Vol.15 (1), p.36-42 |
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| container_title | Bioorganic & medicinal chemistry |
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| creator | Avery, Thomas D. Macreadie, Peter I. Greatrex, Ben W. Robinson, Tony V. Taylor, Dennis K. Macreadie, Ian G. |
| description | Broad antifungal structure–activity relationships governing epoxy-endoperoxides
2 and
3 and their parent endoperoxides
1 are reported. Their inhibitory activity against
Candida albicans in conjunction with hemolytic activity and/or growth inhibition of cultured mammalian cells are reported. This information provided guidance for the further development of endoperoxide and epoxy-endoperoxides as topical antifungal agents. |
| doi_str_mv | 10.1016/j.bmc.2006.10.021 |
| format | Article |
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2 and
3 and their parent endoperoxides
1 are reported. Their inhibitory activity against
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2 and
3 and their parent endoperoxides
1 are reported. Their inhibitory activity against
Candida albicans in conjunction with hemolytic activity and/or growth inhibition of cultured mammalian cells are reported. 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2 and
3 and their parent endoperoxides
1 are reported. Their inhibitory activity against
Candida albicans in conjunction with hemolytic activity and/or growth inhibition of cultured mammalian cells are reported. This information provided guidance for the further development of endoperoxide and epoxy-endoperoxides as topical antifungal agents.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>17079152</pmid><doi>10.1016/j.bmc.2006.10.021</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0968-0896 |
| ispartof | Bioorganic & medicinal chemistry, 2007, Vol.15 (1), p.36-42 |
| issn | 0968-0896 1464-3391 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_68358453 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Animals Antifungal Antifungal Agents - chemical synthesis Antifungal Agents - chemistry Antifungal Agents - pharmacology Artemisinin Candida Candida albicans Candida albicans - drug effects Cell Proliferation - drug effects CHO Cells Cricetinae Drug Design Endoperoxide Erythrocytes - drug effects Growth inhibition Hemolytic activity Humans Microbial Sensitivity Tests Molecular Conformation Peroxides - chemical synthesis Peroxides - chemistry Peroxides - pharmacology Stereoisomerism Structure-Activity Relationship |
| title | Design of endoperoxides with anti- Candida activity |
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