Total Synthesis of (-)-Episilvestrol and (-)-Silvestrol

Sugar and spice…︁ The total synthesis of the rare but potent anticancer natural product (−)‐episilvestrol and its 5′′′ epimer (−)‐silvestrol was accomplished from D‐glucose, naringenin, and methyl cinnamate (see scheme). The key steps of the sequence were inspired by the possible biogenesis of these...

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Veröffentlicht in:	Angewandte Chemie (International ed.) 2007-01, Vol.46 (41), p.7835-7838
Hauptverfasser:	El Sous, Mariana, Khoo, Mui Ling, Holloway, Georgina, Owen, David, Scammells, Peter J, Rizzacasa, Mark A
Format:	Artikel
Sprache:	eng
Schlagworte:	antitumor agents Benzofurans - chemical synthesis Benzofurans - chemistry cycloaddition Macrocyclic Compounds - chemical synthesis Macrocyclic Compounds - chemistry Models, Chemical Molecular Structure natural products total synthesis Triterpenes - chemical synthesis Triterpenes - chemistry
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