Protein-Resistant Silicones: Incorporation of Poly(ethylene oxide) via Siloxane Tethers
Silicones with enhanced protein resistance were prepared by introducing poly(ethylene oxide) (PEO) chains via siloxane tethers (a−c) of varying lengths. Three unique ambifunctional molecules (a−c) having the general formula α-(EtO)3Si(CH2)2-oligodimethylsiloxane n -block-poly(ethylene oxide)8-OCH3 (...
Gespeichert in:
| Veröffentlicht in: | Biomacromolecules 2007-10, Vol.8 (10), p.3244-3252 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 3252 |
|---|---|
| container_issue | 10 |
| container_start_page | 3244 |
| container_title | Biomacromolecules |
| container_volume | 8 |
| creator | Murthy, Ranjini Cox, Casey D Hahn, Mariah S Grunlan, Melissa A |
| description | Silicones with enhanced protein resistance were prepared by introducing poly(ethylene oxide) (PEO) chains via siloxane tethers (a−c) of varying lengths. Three unique ambifunctional molecules (a−c) having the general formula α-(EtO)3Si(CH2)2-oligodimethylsiloxane n -block-poly(ethylene oxide)8-OCH3 (n = 0 (a), 4, (b), and 13 (c)) were prepared via regioselective Rh-catalyzed hydrosilylation. Nine films were subsequently produced by the H3PO4-catalyzed sol−gel cross-linking of a−c each with α,ω-bis(Si−OH)polydimethylsiloxane (P, M n = 3000 g/mol) in varying ratios (1:1, 1:2, and 2:3 molar ratio a, b, or c to P). Films prepared with a 2:3 molar ratio (a−c to P) contained the least amount of un-cross-linked materials, which may migrate to the film surface. For this set of films, surface hydrophilicity and protein resistance increased with siloxane tether length (a−c). These results indicate that PEO was more effectively mobilized to the surface if incorporated into silicones via longer siloxane tethers. |
| doi_str_mv | 10.1021/bm700543c |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_68358006</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>68358006</sourcerecordid><originalsourceid>FETCH-LOGICAL-a343t-88e8ea83fb3332945b079626d6b6c35bacfe95ac70e786d156c459c4f27863983</originalsourceid><addsrcrecordid>eNptkLtOwzAUhi0EolAYeAGUBUSHgBNfw4YqLpUqUUFZWCLHORGu0rjYCWo3Vl6TJyGlEV2Yzu07_zn6ETqJ8GWE4-gqmwuMGSV6Bx1ELOYh5Tje_c1ZKEQieujQ-xnGOCGU7aNeJETMCCcH6HXibA2mCp_AG1-rqg6eTWm0rcBff39-BaNKW7ewTtXGVoEtgoktVxdQv61KqCCwS5PDIPgwar1nl6rtTdspOH-E9gpVejjuYh-93N1Ohw_h-PF-NLwZh4pQUodSggQlSZERQuKEsgyLhMc85xnXhGVKF5AwpQUGIXkeMa4pSzQt4rYkiSR9dL7RXTj73oCv07nxGsqy_cU2PuWSMIkxb8HBBtTOeu-gSBfOzJVbpRFO10amf0a27Gkn2mRzyLdk51wLnHWA8lqVhVOVNn7LJZGQVIotp7RPZ7ZxVevFPwd_AMiHh3U</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>68358006</pqid></control><display><type>article</type><title>Protein-Resistant Silicones: Incorporation of Poly(ethylene oxide) via Siloxane Tethers</title><source>MEDLINE</source><source>ACS Publications</source><creator>Murthy, Ranjini ; Cox, Casey D ; Hahn, Mariah S ; Grunlan, Melissa A</creator><creatorcontrib>Murthy, Ranjini ; Cox, Casey D ; Hahn, Mariah S ; Grunlan, Melissa A</creatorcontrib><description>Silicones with enhanced protein resistance were prepared by introducing poly(ethylene oxide) (PEO) chains via siloxane tethers (a−c) of varying lengths. Three unique ambifunctional molecules (a−c) having the general formula α-(EtO)3Si(CH2)2-oligodimethylsiloxane n -block-poly(ethylene oxide)8-OCH3 (n = 0 (a), 4, (b), and 13 (c)) were prepared via regioselective Rh-catalyzed hydrosilylation. Nine films were subsequently produced by the H3PO4-catalyzed sol−gel cross-linking of a−c each with α,ω-bis(Si−OH)polydimethylsiloxane (P, M n = 3000 g/mol) in varying ratios (1:1, 1:2, and 2:3 molar ratio a, b, or c to P). Films prepared with a 2:3 molar ratio (a−c to P) contained the least amount of un-cross-linked materials, which may migrate to the film surface. For this set of films, surface hydrophilicity and protein resistance increased with siloxane tether length (a−c). These results indicate that PEO was more effectively mobilized to the surface if incorporated into silicones via longer siloxane tethers.</description><identifier>ISSN: 1525-7797</identifier><identifier>EISSN: 1526-4602</identifier><identifier>DOI: 10.1021/bm700543c</identifier><identifier>PMID: 17725363</identifier><language>eng</language><publisher>Washington, DC: American Chemical Society</publisher><subject>Adsorption ; Animals ; Applied sciences ; Biocompatible Materials - chemistry ; Cattle ; Cross-Linking Reagents - chemistry ; Exact sciences and technology ; Inorganic and organomineral polymers ; Models, Chemical ; Phase Transition ; Physicochemistry of polymers ; Polyethylene Glycols - chemistry ; Polymers - chemistry ; Preparation ; Serum Albumin - chemistry ; Silicones - chemistry ; Siloxanes - chemistry ; Spectrometry, X-Ray Emission ; Spectrophotometry, Infrared - methods ; Surface Properties ; Thermogravimetry</subject><ispartof>Biomacromolecules, 2007-10, Vol.8 (10), p.3244-3252</ispartof><rights>Copyright © 2007 American Chemical Society</rights><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a343t-88e8ea83fb3332945b079626d6b6c35bacfe95ac70e786d156c459c4f27863983</citedby><cites>FETCH-LOGICAL-a343t-88e8ea83fb3332945b079626d6b6c35bacfe95ac70e786d156c459c4f27863983</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/bm700543c$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/bm700543c$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,780,784,2763,27075,27923,27924,56737,56787</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19178487$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17725363$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Murthy, Ranjini</creatorcontrib><creatorcontrib>Cox, Casey D</creatorcontrib><creatorcontrib>Hahn, Mariah S</creatorcontrib><creatorcontrib>Grunlan, Melissa A</creatorcontrib><title>Protein-Resistant Silicones: Incorporation of Poly(ethylene oxide) via Siloxane Tethers</title><title>Biomacromolecules</title><addtitle>Biomacromolecules</addtitle><description>Silicones with enhanced protein resistance were prepared by introducing poly(ethylene oxide) (PEO) chains via siloxane tethers (a−c) of varying lengths. Three unique ambifunctional molecules (a−c) having the general formula α-(EtO)3Si(CH2)2-oligodimethylsiloxane n -block-poly(ethylene oxide)8-OCH3 (n = 0 (a), 4, (b), and 13 (c)) were prepared via regioselective Rh-catalyzed hydrosilylation. Nine films were subsequently produced by the H3PO4-catalyzed sol−gel cross-linking of a−c each with α,ω-bis(Si−OH)polydimethylsiloxane (P, M n = 3000 g/mol) in varying ratios (1:1, 1:2, and 2:3 molar ratio a, b, or c to P). Films prepared with a 2:3 molar ratio (a−c to P) contained the least amount of un-cross-linked materials, which may migrate to the film surface. For this set of films, surface hydrophilicity and protein resistance increased with siloxane tether length (a−c). These results indicate that PEO was more effectively mobilized to the surface if incorporated into silicones via longer siloxane tethers.</description><subject>Adsorption</subject><subject>Animals</subject><subject>Applied sciences</subject><subject>Biocompatible Materials - chemistry</subject><subject>Cattle</subject><subject>Cross-Linking Reagents - chemistry</subject><subject>Exact sciences and technology</subject><subject>Inorganic and organomineral polymers</subject><subject>Models, Chemical</subject><subject>Phase Transition</subject><subject>Physicochemistry of polymers</subject><subject>Polyethylene Glycols - chemistry</subject><subject>Polymers - chemistry</subject><subject>Preparation</subject><subject>Serum Albumin - chemistry</subject><subject>Silicones - chemistry</subject><subject>Siloxanes - chemistry</subject><subject>Spectrometry, X-Ray Emission</subject><subject>Spectrophotometry, Infrared - methods</subject><subject>Surface Properties</subject><subject>Thermogravimetry</subject><issn>1525-7797</issn><issn>1526-4602</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkLtOwzAUhi0EolAYeAGUBUSHgBNfw4YqLpUqUUFZWCLHORGu0rjYCWo3Vl6TJyGlEV2Yzu07_zn6ETqJ8GWE4-gqmwuMGSV6Bx1ELOYh5Tje_c1ZKEQieujQ-xnGOCGU7aNeJETMCCcH6HXibA2mCp_AG1-rqg6eTWm0rcBff39-BaNKW7ewTtXGVoEtgoktVxdQv61KqCCwS5PDIPgwar1nl6rtTdspOH-E9gpVejjuYh-93N1Ohw_h-PF-NLwZh4pQUodSggQlSZERQuKEsgyLhMc85xnXhGVKF5AwpQUGIXkeMa4pSzQt4rYkiSR9dL7RXTj73oCv07nxGsqy_cU2PuWSMIkxb8HBBtTOeu-gSBfOzJVbpRFO10amf0a27Gkn2mRzyLdk51wLnHWA8lqVhVOVNn7LJZGQVIotp7RPZ7ZxVevFPwd_AMiHh3U</recordid><startdate>20071001</startdate><enddate>20071001</enddate><creator>Murthy, Ranjini</creator><creator>Cox, Casey D</creator><creator>Hahn, Mariah S</creator><creator>Grunlan, Melissa A</creator><general>American Chemical Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20071001</creationdate><title>Protein-Resistant Silicones: Incorporation of Poly(ethylene oxide) via Siloxane Tethers</title><author>Murthy, Ranjini ; Cox, Casey D ; Hahn, Mariah S ; Grunlan, Melissa A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a343t-88e8ea83fb3332945b079626d6b6c35bacfe95ac70e786d156c459c4f27863983</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adsorption</topic><topic>Animals</topic><topic>Applied sciences</topic><topic>Biocompatible Materials - chemistry</topic><topic>Cattle</topic><topic>Cross-Linking Reagents - chemistry</topic><topic>Exact sciences and technology</topic><topic>Inorganic and organomineral polymers</topic><topic>Models, Chemical</topic><topic>Phase Transition</topic><topic>Physicochemistry of polymers</topic><topic>Polyethylene Glycols - chemistry</topic><topic>Polymers - chemistry</topic><topic>Preparation</topic><topic>Serum Albumin - chemistry</topic><topic>Silicones - chemistry</topic><topic>Siloxanes - chemistry</topic><topic>Spectrometry, X-Ray Emission</topic><topic>Spectrophotometry, Infrared - methods</topic><topic>Surface Properties</topic><topic>Thermogravimetry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Murthy, Ranjini</creatorcontrib><creatorcontrib>Cox, Casey D</creatorcontrib><creatorcontrib>Hahn, Mariah S</creatorcontrib><creatorcontrib>Grunlan, Melissa A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biomacromolecules</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Murthy, Ranjini</au><au>Cox, Casey D</au><au>Hahn, Mariah S</au><au>Grunlan, Melissa A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Protein-Resistant Silicones: Incorporation of Poly(ethylene oxide) via Siloxane Tethers</atitle><jtitle>Biomacromolecules</jtitle><addtitle>Biomacromolecules</addtitle><date>2007-10-01</date><risdate>2007</risdate><volume>8</volume><issue>10</issue><spage>3244</spage><epage>3252</epage><pages>3244-3252</pages><issn>1525-7797</issn><eissn>1526-4602</eissn><abstract>Silicones with enhanced protein resistance were prepared by introducing poly(ethylene oxide) (PEO) chains via siloxane tethers (a−c) of varying lengths. Three unique ambifunctional molecules (a−c) having the general formula α-(EtO)3Si(CH2)2-oligodimethylsiloxane n -block-poly(ethylene oxide)8-OCH3 (n = 0 (a), 4, (b), and 13 (c)) were prepared via regioselective Rh-catalyzed hydrosilylation. Nine films were subsequently produced by the H3PO4-catalyzed sol−gel cross-linking of a−c each with α,ω-bis(Si−OH)polydimethylsiloxane (P, M n = 3000 g/mol) in varying ratios (1:1, 1:2, and 2:3 molar ratio a, b, or c to P). Films prepared with a 2:3 molar ratio (a−c to P) contained the least amount of un-cross-linked materials, which may migrate to the film surface. For this set of films, surface hydrophilicity and protein resistance increased with siloxane tether length (a−c). These results indicate that PEO was more effectively mobilized to the surface if incorporated into silicones via longer siloxane tethers.</abstract><cop>Washington, DC</cop><pub>American Chemical Society</pub><pmid>17725363</pmid><doi>10.1021/bm700543c</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1525-7797 |
| ispartof | Biomacromolecules, 2007-10, Vol.8 (10), p.3244-3252 |
| issn | 1525-7797 1526-4602 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_68358006 |
| source | MEDLINE; ACS Publications |
| subjects | Adsorption Animals Applied sciences Biocompatible Materials - chemistry Cattle Cross-Linking Reagents - chemistry Exact sciences and technology Inorganic and organomineral polymers Models, Chemical Phase Transition Physicochemistry of polymers Polyethylene Glycols - chemistry Polymers - chemistry Preparation Serum Albumin - chemistry Silicones - chemistry Siloxanes - chemistry Spectrometry, X-Ray Emission Spectrophotometry, Infrared - methods Surface Properties Thermogravimetry |
| title | Protein-Resistant Silicones: Incorporation of Poly(ethylene oxide) via Siloxane Tethers |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-11T15%3A58%3A32IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Protein-Resistant%20Silicones:%E2%80%89%20Incorporation%20of%20Poly(ethylene%20oxide)%20via%20Siloxane%20Tethers&rft.jtitle=Biomacromolecules&rft.au=Murthy,%20Ranjini&rft.date=2007-10-01&rft.volume=8&rft.issue=10&rft.spage=3244&rft.epage=3252&rft.pages=3244-3252&rft.issn=1525-7797&rft.eissn=1526-4602&rft_id=info:doi/10.1021/bm700543c&rft_dat=%3Cproquest_cross%3E68358006%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=68358006&rft_id=info:pmid/17725363&rfr_iscdi=true |