Genomics of TGF-beta1 signaling in stem cell commitment and dendritic cell development
Dendritic cells are professional antigen presenting cells and central for establishing and maintaining immunity and immunological tolerance. They develop from hematopoietic stem cells through successive steps of lineage commitment and differentiation. Dendritic cell development and function are regu...
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| Veröffentlicht in: | Cellular immunology 2006-12, Vol.244 (2), p.116-120 |
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| container_title | Cellular immunology |
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| creator | Ruau, David Ju, Xin-Sheng Zenke, Martin |
| description | Dendritic cells are professional antigen presenting cells and central for establishing and maintaining immunity and immunological tolerance. They develop from hematopoietic stem cells through successive steps of lineage commitment and differentiation. Dendritic cell development and function are regulated by specific cytokines, including transforming growth factor type beta1 (TGF-beta1). Our previous work demonstrated the importance of TGF-beta1 signaling for dendritic cell development and subset specification. Here, we used genome-wide gene expression profiling with DNA microarrays to investigate the activity of TGF-beta1 on gene expression in dendritic cell development. This study identified specific gene categories induced by TGF-beta1 with an impact on dendritic cell biology. |
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This study identified specific gene categories induced by TGF-beta1 with an impact on dendritic cell biology.</description><subject>Dendritic Cells - cytology</subject><subject>Dendritic Cells - immunology</subject><subject>Genomics</subject><subject>Humans</subject><subject>Oligonucleotide Array Sequence Analysis</subject><subject>Principal Component Analysis</subject><subject>Signal Transduction</subject><subject>Stem Cells - cytology</subject><subject>Stem Cells - immunology</subject><subject>Transforming Growth Factor beta1 - genetics</subject><subject>Transforming Growth Factor beta1 - immunology</subject><subject>Transforming Growth Factor beta1 - metabolism</subject><issn>0008-8749</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kM1OwzAQhH0A0VJ4BeQTt0h2bMfxEVU0IFXiQMU18s-mMoqdEDtIvD2p2p5GO_NpdzU3aE0IqYtacrVC9yl9E0IpV-QOrajkjPNKrtFXA3EI3iY8dPjQ7AoDWVOc_DHq3scj9hGnDAFb6HtshxB8DhAz1tFhB9FNPnt7Th38Qj-Mp_gB3Xa6T_B40Q363L0etm_F_qN5377si1FwWVAmaamgrCww55SVwoElZc0WiwiqqFLOWie0KfUyODC8ZrxWxrLOdIJt0PN56zgNPzOk3AafTq_oCMOc2qpmYjlxAp8u4GwCuHacfNDTX3vtgf0D-vhYyw</recordid><startdate>200612</startdate><enddate>200612</enddate><creator>Ruau, David</creator><creator>Ju, Xin-Sheng</creator><creator>Zenke, Martin</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>200612</creationdate><title>Genomics of TGF-beta1 signaling in stem cell commitment and dendritic cell development</title><author>Ruau, David ; Ju, Xin-Sheng ; Zenke, Martin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p547-137129e26ce3dd9c75dec0283e260519199dccd5ab2a919deb483489bc3fbf53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Dendritic Cells - cytology</topic><topic>Dendritic Cells - immunology</topic><topic>Genomics</topic><topic>Humans</topic><topic>Oligonucleotide Array Sequence Analysis</topic><topic>Principal Component Analysis</topic><topic>Signal Transduction</topic><topic>Stem Cells - cytology</topic><topic>Stem Cells - immunology</topic><topic>Transforming Growth Factor beta1 - genetics</topic><topic>Transforming Growth Factor beta1 - immunology</topic><topic>Transforming Growth Factor beta1 - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ruau, David</creatorcontrib><creatorcontrib>Ju, Xin-Sheng</creatorcontrib><creatorcontrib>Zenke, Martin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Cellular immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ruau, David</au><au>Ju, Xin-Sheng</au><au>Zenke, Martin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genomics of TGF-beta1 signaling in stem cell commitment and dendritic cell development</atitle><jtitle>Cellular immunology</jtitle><addtitle>Cell Immunol</addtitle><date>2006-12</date><risdate>2006</risdate><volume>244</volume><issue>2</issue><spage>116</spage><epage>120</epage><pages>116-120</pages><issn>0008-8749</issn><abstract>Dendritic cells are professional antigen presenting cells and central for establishing and maintaining immunity and immunological tolerance. 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| ispartof | Cellular immunology, 2006-12, Vol.244 (2), p.116-120 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Dendritic Cells - cytology Dendritic Cells - immunology Genomics Humans Oligonucleotide Array Sequence Analysis Principal Component Analysis Signal Transduction Stem Cells - cytology Stem Cells - immunology Transforming Growth Factor beta1 - genetics Transforming Growth Factor beta1 - immunology Transforming Growth Factor beta1 - metabolism |
| title | Genomics of TGF-beta1 signaling in stem cell commitment and dendritic cell development |
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