Regulation of Human Lung Adenocarcinoma Cell Migration and Invasion by Macrophage Migration Inhibitory Factor

Macrophage migration inhibitory factor (MIF) is expressed and secreted in response to mitogens and integrin-dependent cell adhesion. Once released, autocrine MIF promotes the activation of RhoA GTPase leading to cell cycle progression in rodent fibroblasts. We now report that small interfering RNA-m...

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Veröffentlicht in:	The Journal of biological chemistry 2007-10, Vol.282 (41), p.29910-29918
Hauptverfasser:	Rendon, Beatriz E., Roger, Thierry, Teneng, Ivo, Zhao, Ming, Al-Abed, Yousef, Calandra, Thierry, Mitchell, Robert A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - embryology Adenocarcinoma - pathology Adenoviridae - genetics Adenovirus Caveolin 1 - metabolism Cell Line, Tumor Cell Movement Gene Expression Regulation, Neoplastic Humans Lung Neoplasms - metabolism Lung Neoplasms - pathology Macrophage Migration-Inhibitory Factors - physiology Membrane Microdomains - metabolism Models, Biological Mutation Neoplasm Invasiveness rhoA GTP-Binding Protein - metabolism RNA, Small Interfering - metabolism
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