Functional changes in the vanilloid receptor subtype 1 channel during and after acute desensitization

Abstract Agonist-induced desensitization of the transient receptor potential vanilloid receptor-1 (TRPV1) is one of the key strategies that offer a way to alleviate neuropathic and inflammatory pain. This process is initiated by TRPV1 receptor activation and the subsequent entry of extracellular Ca2...

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Veröffentlicht in:	Neuroscience 2007-10, Vol.149 (1), p.144-154
Hauptverfasser:	Novakova-Tousova, K, Vyklicky, L, Susankova, K, Benedikt, J, Samad, A, Teisinger, J, Vlachova, V
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Calcium - metabolism Calcium-Calmodulin-Dependent Protein Kinase Type 2 - metabolism capsaicin Capsaicin - pharmacology Cell Line, Transformed desensitization Dose-Response Relationship, Drug Electric Stimulation - methods Fundamental and applied biological sciences. Psychology Humans Membrane Potentials - drug effects Membrane Potentials - genetics Membrane Potentials - physiology Membrane Potentials - radiation effects Mutation - physiology Neurology Patch-Clamp Techniques - methods Phosphatidylinositol 4,5-Diphosphate - pharmacology Rats Structure-Activity Relationship structure-function relationship Temperature Transfection TRP channels TRPV Cation Channels - genetics TRPV Cation Channels - physiology vanilloid receptor Vertebrates: nervous system and sense organs
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