Bucillamine mechanism inhibiting IL-1beta-induced VEGF production from fibroblast-like synoviocytes

We investigated the bucillamine (Buc) mechanism inhibiting interleukin (IL)-1beta-induced vascular endothelial growth factor (VEGF) production from human fibroblast-like synoviocytes (HFLS) which derived from the inflamed synovium of an RA patient using SA981, its active metabolite. HFLS did not pro...

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Veröffentlicht in:	International immunopharmacology 2007-12, Vol.7 (12), p.1569-1576
Hauptverfasser:	Tsuji, Fumio, Seki, Iwao, Aono, Hiroyuki, Odani, Noriko, Mizutani, Keiko, Okamoto, Masahiro, Sasano, Minoru
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Inflammatory Agents, Non-Steroidal - pharmacology Aryl Hydrocarbon Receptor Nuclear Translocator - metabolism Cell Line Cysteine - analogs & derivatives Cysteine - pharmacology Dose-Response Relationship, Drug Fibroblasts - cytology Fibroblasts - drug effects Fibroblasts - metabolism Humans Hypoxia-Inducible Factor 1, alpha Subunit - metabolism I-kappa B Proteins - metabolism Interleukin-1beta - pharmacology Interleukin-6 - metabolism Interleukin-6 - pharmacology Mitogen-Activated Protein Kinases - metabolism NF-KappaB Inhibitor alpha Phosphorylation - drug effects Proto-Oncogene Proteins c-akt - metabolism Proto-Oncogene Proteins c-jun - metabolism Sp1 Transcription Factor - metabolism Synovial Membrane - cytology Synovial Membrane - drug effects Synovial Membrane - metabolism Transcription Factor AP-1 - metabolism Vascular Endothelial Growth Factor A - metabolism
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