Sex Specific Associations between Common Glucocorticoid Receptor Gene Variants and Hypothalamus-Pituitary-Adrenal Axis Responses to Psychosocial Stress

Background Alterations in glucocorticoid (GC) signaling have been associated with a number of psychiatric disorders. Genetic variation of the glucocorticoid receptor (GR) might be one of the factors underlying susceptibility to stress related disease. Methods We investigated 206 healthy subjects and...

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Veröffentlicht in:	Biological psychiatry (1969) 2007-10, Vol.62 (8), p.863-869
Hauptverfasser:	Kumsta, Robert, Entringer, Sonja, Koper, Jan W, van Rossum, Elisabeth F.C, Hellhammer, Dirk H, Wüst, Stefan
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptation, Physiological - genetics Adaptation, Psychological Adrenocorticotropic Hormone - blood Adrenocorticotropic Hormone - drug effects Adult Analysis of Variance Contraceptives, Oral - pharmacology Ethinyl Estradiol - pharmacology Female Genetic Variation Glucocortcoid receptor gene polymorphism glucocorticoid sensitivity Haplotypes Humans Hydrocortisone - metabolism Hypothalamo-Hypophyseal System - drug effects Hypothalamo-Hypophyseal System - physiology hypothalamus-pituitary-adrenal (HPA) axis Linkage Disequilibrium Male Pituitary-Adrenal System - drug effects Pituitary-Adrenal System - physiology Polymorphism, Genetic Psychiatry Psychologie. Psychanalyse. Psychiatrie Psychopathologie. Psychiatrie psychosocial stress Receptors, Glucocorticoid - genetics Reference Values Saliva - metabolism Sciences biologiques et medicales Sciences medicales Sex Factors Stress, Psychological - genetics Stress, Psychological - metabolism
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