CD8 T cell memory development: CD4 T cell help is appreciated

An important goal of vaccination strategies is to elicit long term, effective immunity. Therefore it is imperative to define the parameters that regulate the development and preservation of the numbers and functional quality of cells that confer this property to the host. CD8 T cells are a key compo...

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Veröffentlicht in:	Immunologic research 2007-11, Vol.39 (1-3), p.94-104
Hauptverfasser:	Khanolkar, Aaruni, Badovinac, Vladimir P, Harty, John T
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptive immunity Animals CD4 antigen CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - metabolism CD40 Antigens - immunology CD40 Antigens - metabolism CD40 Ligand - immunology CD40 Ligand - metabolism CD8 antigen CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - metabolism Effector cells Humans Immune response Immune system Immunologic Memory Immunological memory Immunology Infections Interleukin-2 - immunology Interleukin-2 - metabolism Lymphocytes Lymphocytes T Medical research Memory cells Pathogens Pathology T cell receptors T-Lymphocytes, Helper-Inducer - immunology T-Lymphocytes, Helper-Inducer - metabolism TNF-Related Apoptosis-Inducing Ligand - immunology TNF-Related Apoptosis-Inducing Ligand - metabolism Vaccination Viruses
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