CD8 T cell memory development: CD4 T cell help is appreciated
An important goal of vaccination strategies is to elicit long term, effective immunity. Therefore it is imperative to define the parameters that regulate the development and preservation of the numbers and functional quality of cells that confer this property to the host. CD8 T cells are a key compo...
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| Veröffentlicht in: | Immunologic research 2007-11, Vol.39 (1-3), p.94-104 |
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| container_title | Immunologic research |
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| creator | Khanolkar, Aaruni Badovinac, Vladimir P Harty, John T |
| description | An important goal of vaccination strategies is to elicit long term, effective immunity. Therefore it is imperative to define the parameters that regulate the development and preservation of the numbers and functional quality of cells that confer this property to the host. CD8 T cells are a key component of the host adaptive immune response that helps eradicate invading viruses and other cell-associated pathogens. Once the primary infection is controlled, the CD8 T cells transition from being effector cells into memory cells that act as sentinels of the immune system capable of rapidly purging the host of recurrent infections by the same pathogen. The factors that regulate and orchestrate this transition from effector CD8 T cells into functionally robust memory CD8 T cells are poorly understood. In recent years it has been determined that CD4 T cells play a vital role in the survival and functional responsiveness of memory CD8 T cells. However, the mechanism(s) of this interaction are still unclear. |
| doi_str_mv | 10.1007/s12026-007-0081-4 |
| format | Article |
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Therefore it is imperative to define the parameters that regulate the development and preservation of the numbers and functional quality of cells that confer this property to the host. CD8 T cells are a key component of the host adaptive immune response that helps eradicate invading viruses and other cell-associated pathogens. Once the primary infection is controlled, the CD8 T cells transition from being effector cells into memory cells that act as sentinels of the immune system capable of rapidly purging the host of recurrent infections by the same pathogen. The factors that regulate and orchestrate this transition from effector CD8 T cells into functionally robust memory CD8 T cells are poorly understood. In recent years it has been determined that CD4 T cells play a vital role in the survival and functional responsiveness of memory CD8 T cells. However, the mechanism(s) of this interaction are still unclear.</description><subject>Adaptive immunity</subject><subject>Animals</subject><subject>CD4 antigen</subject><subject>CD4-Positive T-Lymphocytes - immunology</subject><subject>CD4-Positive T-Lymphocytes - metabolism</subject><subject>CD40 Antigens - immunology</subject><subject>CD40 Antigens - metabolism</subject><subject>CD40 Ligand - immunology</subject><subject>CD40 Ligand - metabolism</subject><subject>CD8 antigen</subject><subject>CD8-Positive T-Lymphocytes - immunology</subject><subject>CD8-Positive T-Lymphocytes - metabolism</subject><subject>Effector cells</subject><subject>Humans</subject><subject>Immune response</subject><subject>Immune system</subject><subject>Immunologic Memory</subject><subject>Immunological memory</subject><subject>Immunology</subject><subject>Infections</subject><subject>Interleukin-2 - immunology</subject><subject>Interleukin-2 - metabolism</subject><subject>Lymphocytes</subject><subject>Lymphocytes T</subject><subject>Medical research</subject><subject>Memory cells</subject><subject>Pathogens</subject><subject>Pathology</subject><subject>T cell receptors</subject><subject>T-Lymphocytes, Helper-Inducer - immunology</subject><subject>T-Lymphocytes, Helper-Inducer - metabolism</subject><subject>TNF-Related Apoptosis-Inducing Ligand - immunology</subject><subject>TNF-Related Apoptosis-Inducing Ligand - metabolism</subject><subject>Vaccination</subject><subject>Viruses</subject><issn>0257-277X</issn><issn>1559-0755</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkVtLxDAQhYMo7rr6A3yRouBbNZNLkwg-SNcbLPiygm-hlwS7tNuatML-e1N2RRDEh2EG5pvDHA5Cp4CvAGNx7YFgksRhDCUhZntoCpyrGAvO99EUEy5iIsTbBB15v8IYEsboIZqAUCAwl1N0m85ltIwKU9dRY5rWbaLSfJq67Rqz7m-idM6-1--m7qLKR1nXOVNUWW_KY3Rgs9qbk12fodeH-2X6FC9eHp_Tu0VcMCL7WOGcU8ISKohUimVJKbEgiSkxsZjnlkHJLMsLYq0qgFBLheClUhy4lMpyOkOXW93OtR-D8b1uKj8-la1NO3idSMqUSNS_IChOIVgP4MUvcNUObh1MaJIoTojESgbq_C8qKCkMQo4QbKHCtd47Y3XnqiZzGw1YjznpbU56HMecNAs3ZzvhIW9M-XOxC4Z-ASVmiJM</recordid><startdate>200711</startdate><enddate>200711</enddate><creator>Khanolkar, Aaruni</creator><creator>Badovinac, Vladimir P</creator><creator>Harty, John T</creator><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>200711</creationdate><title>CD8 T cell memory development: CD4 T cell help is appreciated</title><author>Khanolkar, Aaruni ; 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Therefore it is imperative to define the parameters that regulate the development and preservation of the numbers and functional quality of cells that confer this property to the host. CD8 T cells are a key component of the host adaptive immune response that helps eradicate invading viruses and other cell-associated pathogens. Once the primary infection is controlled, the CD8 T cells transition from being effector cells into memory cells that act as sentinels of the immune system capable of rapidly purging the host of recurrent infections by the same pathogen. The factors that regulate and orchestrate this transition from effector CD8 T cells into functionally robust memory CD8 T cells are poorly understood. In recent years it has been determined that CD4 T cells play a vital role in the survival and functional responsiveness of memory CD8 T cells. 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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Adaptive immunity Animals CD4 antigen CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - metabolism CD40 Antigens - immunology CD40 Antigens - metabolism CD40 Ligand - immunology CD40 Ligand - metabolism CD8 antigen CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - metabolism Effector cells Humans Immune response Immune system Immunologic Memory Immunological memory Immunology Infections Interleukin-2 - immunology Interleukin-2 - metabolism Lymphocytes Lymphocytes T Medical research Memory cells Pathogens Pathology T cell receptors T-Lymphocytes, Helper-Inducer - immunology T-Lymphocytes, Helper-Inducer - metabolism TNF-Related Apoptosis-Inducing Ligand - immunology TNF-Related Apoptosis-Inducing Ligand - metabolism Vaccination Viruses |
| title | CD8 T cell memory development: CD4 T cell help is appreciated |
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