A new approach to control condylar growth by regulating angiogenesis
Abstract Objective To provide a comprehensive review of the mechanisms of growth of mandibular condyle, the roles of angiogenesis enhancers and inhibitors during endochondral ossification in mandibular condyle and newly developed delivery methods for local gene delivery that may represent strategies...
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| Veröffentlicht in: | Archives of oral biology 2007-11, Vol.52 (11), p.1009-1017 |
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| container_title | Archives of oral biology |
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| creator | Li, Q.F Rabie, A.B.M |
| description | Abstract Objective To provide a comprehensive review of the mechanisms of growth of mandibular condyle, the roles of angiogenesis enhancers and inhibitors during endochondral ossification in mandibular condyle and newly developed delivery methods for local gene delivery that may represent strategies to regulate condylar growth. Design Narrative review. Results Angiogenesis is the crucial step in mandibular condylar growth for it regulates the transformation from cartilage to bone. Angiognesis enhancers, especially VEGF and FGF, play important roles in the process of new blood lumen formation and invasion. On the other hand, angiostatin and endostatin inhibit angiogenesis by targeting endothelial cells and several signal cascades. Delivery methods such as liposomes, stem cells and virus vectors have been studied. Recombinant AAV-mediated gene therapy is considered as one of the most promising strategies of condylar growth management. Conclusion AAV-mediated gene therapy using VEGF or angiogenesis inhibitor will be a promising way to regulate condylar growth at an early stage. |
| doi_str_mv | 10.1016/j.archoralbio.2007.05.009 |
| format | Article |
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Design Narrative review. Results Angiogenesis is the crucial step in mandibular condylar growth for it regulates the transformation from cartilage to bone. Angiognesis enhancers, especially VEGF and FGF, play important roles in the process of new blood lumen formation and invasion. On the other hand, angiostatin and endostatin inhibit angiogenesis by targeting endothelial cells and several signal cascades. Delivery methods such as liposomes, stem cells and virus vectors have been studied. Recombinant AAV-mediated gene therapy is considered as one of the most promising strategies of condylar growth management. Conclusion AAV-mediated gene therapy using VEGF or angiogenesis inhibitor will be a promising way to regulate condylar growth at an early stage.</description><identifier>ISSN: 0003-9969</identifier><identifier>EISSN: 1879-1506</identifier><identifier>DOI: 10.1016/j.archoralbio.2007.05.009</identifier><identifier>PMID: 17640614</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Advanced Basic Science ; Angiogenesis ; Angiogenesis Inhibitors - genetics ; Angiostatin ; Animals ; Cartilage - growth & development ; Condylar growth ; Craniofacial growth deformities ; Dentistry ; Dependovirus - genetics ; Endostatin ; FGF ; Genetic Therapy - methods ; Genetic Vectors - administration & dosage ; Humans ; Intercellular Signaling Peptides and Proteins - genetics ; Mandibular Condyle - abnormalities ; Mandibular Condyle - blood supply ; Mandibular Condyle - growth & development ; Nanotechnology ; Neovascularization, Physiologic ; rAAV ; Stem Cell Transplantation ; Stem cells ; VEGF</subject><ispartof>Archives of oral biology, 2007-11, Vol.52 (11), p.1009-1017</ispartof><rights>Elsevier Ltd</rights><rights>2007 Elsevier Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c430t-50d6f53aff188d3edb380b012133112233dd47e4ce052abb00936b1b78720a0e3</citedby><cites>FETCH-LOGICAL-c430t-50d6f53aff188d3edb380b012133112233dd47e4ce052abb00936b1b78720a0e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.archoralbio.2007.05.009$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,782,786,3552,27931,27932,46002</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17640614$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Q.F</creatorcontrib><creatorcontrib>Rabie, A.B.M</creatorcontrib><title>A new approach to control condylar growth by regulating angiogenesis</title><title>Archives of oral biology</title><addtitle>Arch Oral Biol</addtitle><description>Abstract Objective To provide a comprehensive review of the mechanisms of growth of mandibular condyle, the roles of angiogenesis enhancers and inhibitors during endochondral ossification in mandibular condyle and newly developed delivery methods for local gene delivery that may represent strategies to regulate condylar growth. Design Narrative review. Results Angiogenesis is the crucial step in mandibular condylar growth for it regulates the transformation from cartilage to bone. Angiognesis enhancers, especially VEGF and FGF, play important roles in the process of new blood lumen formation and invasion. On the other hand, angiostatin and endostatin inhibit angiogenesis by targeting endothelial cells and several signal cascades. Delivery methods such as liposomes, stem cells and virus vectors have been studied. Recombinant AAV-mediated gene therapy is considered as one of the most promising strategies of condylar growth management. Conclusion AAV-mediated gene therapy using VEGF or angiogenesis inhibitor will be a promising way to regulate condylar growth at an early stage.</description><subject>Advanced Basic Science</subject><subject>Angiogenesis</subject><subject>Angiogenesis Inhibitors - genetics</subject><subject>Angiostatin</subject><subject>Animals</subject><subject>Cartilage - growth & development</subject><subject>Condylar growth</subject><subject>Craniofacial growth deformities</subject><subject>Dentistry</subject><subject>Dependovirus - genetics</subject><subject>Endostatin</subject><subject>FGF</subject><subject>Genetic Therapy - methods</subject><subject>Genetic Vectors - administration & dosage</subject><subject>Humans</subject><subject>Intercellular Signaling Peptides and Proteins - genetics</subject><subject>Mandibular Condyle - abnormalities</subject><subject>Mandibular Condyle - blood supply</subject><subject>Mandibular Condyle - growth & development</subject><subject>Nanotechnology</subject><subject>Neovascularization, Physiologic</subject><subject>rAAV</subject><subject>Stem Cell Transplantation</subject><subject>Stem cells</subject><subject>VEGF</subject><issn>0003-9969</issn><issn>1879-1506</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU2P0zAQhi0EYruFv4DChVvC2E6c5IK0Kh-LtBIH4Gz5Y5K6uHaxE1b99yRqJRAnTqOR3pl33mcIeU2hokDF20OlktnHpLx2sWIAbQVNBdA_IRvatX1JGxBPyQYAeNn3or8htzkflrYRgj4nN7QVNQhab8j7uyLgY6FOpxSV2RdTLEwMU4p-rfbsVSrGFB-nfaHPRcJx9mpyYSxUGF0cMWB2-QV5Niif8eW1bsn3jx--7e7Lhy-fPu_uHkpTc5jKBqwYGq6GgXad5Wg170ADZZRzShnj3Nq6xdogNExpvQTiQlPddi0DBci35M1l73LszxnzJI8uG_ReBYxzlqLjdc-YWIT9RWhSzDnhIE_JHVU6SwpyRSgP8i-EckUooZGr45a8uprM-oj2z-SV2SLYXQS4RP3lMMlsHAaD1iU0k7TR_ZfNu3-2GO-CM8r_wDPmQ5xTWFhKKjOTIL-uv1xfCS0ArRdYvwFxSpzm</recordid><startdate>20071101</startdate><enddate>20071101</enddate><creator>Li, Q.F</creator><creator>Rabie, A.B.M</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20071101</creationdate><title>A new approach to control condylar growth by regulating angiogenesis</title><author>Li, Q.F ; Rabie, A.B.M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c430t-50d6f53aff188d3edb380b012133112233dd47e4ce052abb00936b1b78720a0e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Advanced Basic Science</topic><topic>Angiogenesis</topic><topic>Angiogenesis Inhibitors - genetics</topic><topic>Angiostatin</topic><topic>Animals</topic><topic>Cartilage - growth & development</topic><topic>Condylar growth</topic><topic>Craniofacial growth deformities</topic><topic>Dentistry</topic><topic>Dependovirus - genetics</topic><topic>Endostatin</topic><topic>FGF</topic><topic>Genetic Therapy - methods</topic><topic>Genetic Vectors - administration & dosage</topic><topic>Humans</topic><topic>Intercellular Signaling Peptides and Proteins - genetics</topic><topic>Mandibular Condyle - abnormalities</topic><topic>Mandibular Condyle - blood supply</topic><topic>Mandibular Condyle - growth & development</topic><topic>Nanotechnology</topic><topic>Neovascularization, Physiologic</topic><topic>rAAV</topic><topic>Stem Cell Transplantation</topic><topic>Stem cells</topic><topic>VEGF</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Q.F</creatorcontrib><creatorcontrib>Rabie, A.B.M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Archives of oral biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Q.F</au><au>Rabie, A.B.M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A new approach to control condylar growth by regulating angiogenesis</atitle><jtitle>Archives of oral biology</jtitle><addtitle>Arch Oral Biol</addtitle><date>2007-11-01</date><risdate>2007</risdate><volume>52</volume><issue>11</issue><spage>1009</spage><epage>1017</epage><pages>1009-1017</pages><issn>0003-9969</issn><eissn>1879-1506</eissn><abstract>Abstract Objective To provide a comprehensive review of the mechanisms of growth of mandibular condyle, the roles of angiogenesis enhancers and inhibitors during endochondral ossification in mandibular condyle and newly developed delivery methods for local gene delivery that may represent strategies to regulate condylar growth. Design Narrative review. Results Angiogenesis is the crucial step in mandibular condylar growth for it regulates the transformation from cartilage to bone. Angiognesis enhancers, especially VEGF and FGF, play important roles in the process of new blood lumen formation and invasion. On the other hand, angiostatin and endostatin inhibit angiogenesis by targeting endothelial cells and several signal cascades. Delivery methods such as liposomes, stem cells and virus vectors have been studied. Recombinant AAV-mediated gene therapy is considered as one of the most promising strategies of condylar growth management. Conclusion AAV-mediated gene therapy using VEGF or angiogenesis inhibitor will be a promising way to regulate condylar growth at an early stage.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>17640614</pmid><doi>10.1016/j.archoralbio.2007.05.009</doi><tpages>9</tpages></addata></record> |
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| ispartof | Archives of oral biology, 2007-11, Vol.52 (11), p.1009-1017 |
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| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Advanced Basic Science Angiogenesis Angiogenesis Inhibitors - genetics Angiostatin Animals Cartilage - growth & development Condylar growth Craniofacial growth deformities Dentistry Dependovirus - genetics Endostatin FGF Genetic Therapy - methods Genetic Vectors - administration & dosage Humans Intercellular Signaling Peptides and Proteins - genetics Mandibular Condyle - abnormalities Mandibular Condyle - blood supply Mandibular Condyle - growth & development Nanotechnology Neovascularization, Physiologic rAAV Stem Cell Transplantation Stem cells VEGF |
| title | A new approach to control condylar growth by regulating angiogenesis |
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