Negative Binomial Meta-Regression Analysis of Combined Glycosylated Hemoglobin and Hypoglycemia Outcomes Across Eleven Phase III and IV Studies of Insulin Glargine Compared with Neutral Protamine Hagedorn Insulin in Type 1 and Type 2 Diabetes Mellitus

Abstract Objectives: This analysis first modeled the interaction between hypoglycemia and glycosylated hemoglobin (HbA2c ) in clinical trials that compared insulin glargine (glargine) with human neutral protamine Hagedorn insulin (NPH) in patients with type 1 or type 2 diabetes mellitus. The model w...

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Veröffentlicht in:	Clinical therapeutics 2007-08, Vol.29 (8), p.1607-1619
Hauptverfasser:	Mullins, Peter, MSc, Sharplin, Peter, MSc, Yki-Jarvinen, Hannele, MD, FRCp, Riddle, Matthew C., MD, Haring, Hans-Ulrich, MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Binomial Distribution Biological and medical sciences Blood Glucose - drug effects Clinical Trials, Phase III as Topic Clinical Trials, Phase IV as Topic Diabetes Diabetes Mellitus, Type 1 - blood Diabetes Mellitus, Type 1 - drug therapy Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - drug therapy Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinology Endocrinopathies Epidemiology Etiopathogenesis. Screening. Investigations. Target tissue resistance glargine Glycated Hemoglobin A - metabolism HbA 1c Hemoglobin Humans Hypoglycemia Hypoglycemia - blood Hypoglycemia - prevention & control Hypoglycemic Agents - therapeutic use Insulin Insulin - analogs & derivatives Insulin - therapeutic use Insulin Glargine Insulin, Isophane - therapeutic use Insulin, Long-Acting Internal Medicine Medical Education Medical sciences Models, Statistical negative binomial regression NPH insulin Patients Pediatrics Pharmacology. Drug treatments Randomized Controlled Trials as Topic Teenagers Treatment Outcome
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