Dose-dependent hypocholesterolemic actions of dietary apple polyphenol in rats fed cholesterol
The dose-dependent hypocholesterolemic and antiatherogenic effects of dietary apple polyphenol (AP) from unripe apple, which contains approximately 85% catechin oligomers (procyanidins), were examined in male Sprague-Dawley rats (4 wk of age) given a purified diet containing 0.5% cholesterol. Dietar...
Gespeichert in:
| Veröffentlicht in: | Lipids 2006-02, Vol.41 (2), p.133-139 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 139 |
|---|---|
| container_issue | 2 |
| container_start_page | 133 |
| container_title | Lipids |
| container_volume | 41 |
| creator | Osada, K Suzuki, T Kawakami, Y Senda, M Kasai, A Sami, M Ohta, Y Kanda, T Ikeda, M |
| description | The dose-dependent hypocholesterolemic and antiatherogenic effects of dietary apple polyphenol (AP) from unripe apple, which contains approximately 85% catechin oligomers (procyanidins), were examined in male Sprague-Dawley rats (4 wk of age) given a purified diet containing 0.5% cholesterol. Dietary AP at 0.5 and 1.0% levels significantly decreased the liver cholesterol level compared with that in the control (AP-free dietfed) group. Dietary AP also significantly lowered the serum cholesterol level compared with that in the control group. However, the HDL cholesterol level was significantly higher in the 1.0% AP fed group than in the control group. Accordingly, the ratio of HDL-cholesterol/total cholesterol was significantly higher in the 0.5% AP-fed group and 1.0% AP-fed group than in the control group. Moreover, the atherogenic indices in the 0.5 and 1.0% AP-fed groups were significantly lower than those in the control group. The activity of hepatic cholesterol 7α-hydroxylase tended to be increased by dietary AP in a dose-dependent manner. In accord with this observation, dietary AP increased the excretion of acidic steroids in feces. Dietary AP also significantly promoted the fecal excretion of neutral steroids in a dose-dependent manner. These observations suggest that dietary AP at 0.5 or 1.0% level exerts hypocholesterolemic and antiatherogenic effects through the promotion of cholesterol catabolism and inhibition of intestinal absorption of cholesterol. |
| doi_str_mv | 10.1007/s11745-006-5081-y |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_68348603</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>68348603</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4643-29786e24be60d7e28abc94f6954f9db83bef0728ec42f4955a7ca03776df992a3</originalsourceid><addsrcrecordid>eNqFkU1v1DAQhi0EotvCD-ACFofeDOOP2PER9QMqrUQl6BXLScZsqmwc7KxQ_n29ykogLpxGIz3vOzPvEPKGwwcOYD5mzo2qGIBmFdScLc_IhldVzawE85xsAIRiSgA_I-c5P5aWK1u9JGfcGDDW2A35cR0zsg4nHDscZ7pbptju4oB5xlTKvm-pb-c-jpnGQLseZ58W6qdpQDrFYZl2OMaB9iNNfs40YEf_0r8iL4IfMr4-1QvycHvz_eoL2379fHf1actapZVkwppao1ANaugMito3rVVB20oF2zW1bDCAETW2SoRyQuVN60Eao7tgrfDyglyuvlOKvw5luNv3ucVh8CPGQ3a6lqrWIAv4_h_wMR7SWHZzwihTyUqLAvEValPMOWFwU-r35W7HwR2Td2vyriTvjsm7pWjenowPzR67P4pT1AUwK_C7H3D5v6Pb3t1fA5fHnd-tyuCj8z9Tn93Dt_JVCRyM1grkE8wimak</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>274753562</pqid></control><display><type>article</type><title>Dose-dependent hypocholesterolemic actions of dietary apple polyphenol in rats fed cholesterol</title><source>MEDLINE</source><source>Wiley Online Library All Journals</source><source>SpringerLink Journals - AutoHoldings</source><creator>Osada, K ; Suzuki, T ; Kawakami, Y ; Senda, M ; Kasai, A ; Sami, M ; Ohta, Y ; Kanda, T ; Ikeda, M</creator><creatorcontrib>Osada, K ; Suzuki, T ; Kawakami, Y ; Senda, M ; Kasai, A ; Sami, M ; Ohta, Y ; Kanda, T ; Ikeda, M</creatorcontrib><description>The dose-dependent hypocholesterolemic and antiatherogenic effects of dietary apple polyphenol (AP) from unripe apple, which contains approximately 85% catechin oligomers (procyanidins), were examined in male Sprague-Dawley rats (4 wk of age) given a purified diet containing 0.5% cholesterol. Dietary AP at 0.5 and 1.0% levels significantly decreased the liver cholesterol level compared with that in the control (AP-free dietfed) group. Dietary AP also significantly lowered the serum cholesterol level compared with that in the control group. However, the HDL cholesterol level was significantly higher in the 1.0% AP fed group than in the control group. Accordingly, the ratio of HDL-cholesterol/total cholesterol was significantly higher in the 0.5% AP-fed group and 1.0% AP-fed group than in the control group. Moreover, the atherogenic indices in the 0.5 and 1.0% AP-fed groups were significantly lower than those in the control group. The activity of hepatic cholesterol 7α-hydroxylase tended to be increased by dietary AP in a dose-dependent manner. In accord with this observation, dietary AP increased the excretion of acidic steroids in feces. Dietary AP also significantly promoted the fecal excretion of neutral steroids in a dose-dependent manner. These observations suggest that dietary AP at 0.5 or 1.0% level exerts hypocholesterolemic and antiatherogenic effects through the promotion of cholesterol catabolism and inhibition of intestinal absorption of cholesterol.</description><identifier>ISSN: 0024-4201</identifier><identifier>EISSN: 1558-9307</identifier><identifier>DOI: 10.1007/s11745-006-5081-y</identifier><identifier>PMID: 17707979</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer‐Verlag</publisher><subject>animal disease models ; Animals ; Anticholesteremic Agents - administration & dosage ; Anticholesteremic Agents - therapeutic use ; Apples ; blood serum ; Body Weight - drug effects ; catechin ; Cholesterol ; Cholesterol 7-alpha-Hydroxylase - metabolism ; Cholesterol, Dietary ; dietary supplements ; disease control ; Excretion ; Feces - chemistry ; Flavonoids - administration & dosage ; Flavonoids - therapeutic use ; human health ; hypercholesterolemia ; Lipid Metabolism - drug effects ; Lipids - blood ; Liver - drug effects ; Male ; Malus - chemistry ; Organ Size - drug effects ; Phenols - administration & dosage ; Phenols - therapeutic use ; Polyphenols ; Rats ; Rats, Sprague-Dawley ; Steroids ; Steroids - metabolism</subject><ispartof>Lipids, 2006-02, Vol.41 (2), p.133-139</ispartof><rights>2006 American Oil Chemists' Society (AOCS)</rights><rights>Copyright AOCS Press Feb 2006</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4643-29786e24be60d7e28abc94f6954f9db83bef0728ec42f4955a7ca03776df992a3</citedby><cites>FETCH-LOGICAL-c4643-29786e24be60d7e28abc94f6954f9db83bef0728ec42f4955a7ca03776df992a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1007%2Fs11745-006-5081-y$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1007%2Fs11745-006-5081-y$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17707979$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Osada, K</creatorcontrib><creatorcontrib>Suzuki, T</creatorcontrib><creatorcontrib>Kawakami, Y</creatorcontrib><creatorcontrib>Senda, M</creatorcontrib><creatorcontrib>Kasai, A</creatorcontrib><creatorcontrib>Sami, M</creatorcontrib><creatorcontrib>Ohta, Y</creatorcontrib><creatorcontrib>Kanda, T</creatorcontrib><creatorcontrib>Ikeda, M</creatorcontrib><title>Dose-dependent hypocholesterolemic actions of dietary apple polyphenol in rats fed cholesterol</title><title>Lipids</title><addtitle>Lipids</addtitle><description>The dose-dependent hypocholesterolemic and antiatherogenic effects of dietary apple polyphenol (AP) from unripe apple, which contains approximately 85% catechin oligomers (procyanidins), were examined in male Sprague-Dawley rats (4 wk of age) given a purified diet containing 0.5% cholesterol. Dietary AP at 0.5 and 1.0% levels significantly decreased the liver cholesterol level compared with that in the control (AP-free dietfed) group. Dietary AP also significantly lowered the serum cholesterol level compared with that in the control group. However, the HDL cholesterol level was significantly higher in the 1.0% AP fed group than in the control group. Accordingly, the ratio of HDL-cholesterol/total cholesterol was significantly higher in the 0.5% AP-fed group and 1.0% AP-fed group than in the control group. Moreover, the atherogenic indices in the 0.5 and 1.0% AP-fed groups were significantly lower than those in the control group. The activity of hepatic cholesterol 7α-hydroxylase tended to be increased by dietary AP in a dose-dependent manner. In accord with this observation, dietary AP increased the excretion of acidic steroids in feces. Dietary AP also significantly promoted the fecal excretion of neutral steroids in a dose-dependent manner. These observations suggest that dietary AP at 0.5 or 1.0% level exerts hypocholesterolemic and antiatherogenic effects through the promotion of cholesterol catabolism and inhibition of intestinal absorption of cholesterol.</description><subject>animal disease models</subject><subject>Animals</subject><subject>Anticholesteremic Agents - administration & dosage</subject><subject>Anticholesteremic Agents - therapeutic use</subject><subject>Apples</subject><subject>blood serum</subject><subject>Body Weight - drug effects</subject><subject>catechin</subject><subject>Cholesterol</subject><subject>Cholesterol 7-alpha-Hydroxylase - metabolism</subject><subject>Cholesterol, Dietary</subject><subject>dietary supplements</subject><subject>disease control</subject><subject>Excretion</subject><subject>Feces - chemistry</subject><subject>Flavonoids - administration & dosage</subject><subject>Flavonoids - therapeutic use</subject><subject>human health</subject><subject>hypercholesterolemia</subject><subject>Lipid Metabolism - drug effects</subject><subject>Lipids - blood</subject><subject>Liver - drug effects</subject><subject>Male</subject><subject>Malus - chemistry</subject><subject>Organ Size - drug effects</subject><subject>Phenols - administration & dosage</subject><subject>Phenols - therapeutic use</subject><subject>Polyphenols</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Steroids</subject><subject>Steroids - metabolism</subject><issn>0024-4201</issn><issn>1558-9307</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkU1v1DAQhi0EotvCD-ACFofeDOOP2PER9QMqrUQl6BXLScZsqmwc7KxQ_n29ykogLpxGIz3vOzPvEPKGwwcOYD5mzo2qGIBmFdScLc_IhldVzawE85xsAIRiSgA_I-c5P5aWK1u9JGfcGDDW2A35cR0zsg4nHDscZ7pbptju4oB5xlTKvm-pb-c-jpnGQLseZ58W6qdpQDrFYZl2OMaB9iNNfs40YEf_0r8iL4IfMr4-1QvycHvz_eoL2379fHf1actapZVkwppao1ANaugMito3rVVB20oF2zW1bDCAETW2SoRyQuVN60Eao7tgrfDyglyuvlOKvw5luNv3ucVh8CPGQ3a6lqrWIAv4_h_wMR7SWHZzwihTyUqLAvEValPMOWFwU-r35W7HwR2Td2vyriTvjsm7pWjenowPzR67P4pT1AUwK_C7H3D5v6Pb3t1fA5fHnd-tyuCj8z9Tn93Dt_JVCRyM1grkE8wimak</recordid><startdate>200602</startdate><enddate>200602</enddate><creator>Osada, K</creator><creator>Suzuki, T</creator><creator>Kawakami, Y</creator><creator>Senda, M</creator><creator>Kasai, A</creator><creator>Sami, M</creator><creator>Ohta, Y</creator><creator>Kanda, T</creator><creator>Ikeda, M</creator><general>Springer‐Verlag</general><general>Springer Nature B.V</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7T7</scope><scope>7TK</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BKSAR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P64</scope><scope>PCBAR</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>200602</creationdate><title>Dose-dependent hypocholesterolemic actions of dietary apple polyphenol in rats fed cholesterol</title><author>Osada, K ; Suzuki, T ; Kawakami, Y ; Senda, M ; Kasai, A ; Sami, M ; Ohta, Y ; Kanda, T ; Ikeda, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4643-29786e24be60d7e28abc94f6954f9db83bef0728ec42f4955a7ca03776df992a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>animal disease models</topic><topic>Animals</topic><topic>Anticholesteremic Agents - administration & dosage</topic><topic>Anticholesteremic Agents - therapeutic use</topic><topic>Apples</topic><topic>blood serum</topic><topic>Body Weight - drug effects</topic><topic>catechin</topic><topic>Cholesterol</topic><topic>Cholesterol 7-alpha-Hydroxylase - metabolism</topic><topic>Cholesterol, Dietary</topic><topic>dietary supplements</topic><topic>disease control</topic><topic>Excretion</topic><topic>Feces - chemistry</topic><topic>Flavonoids - administration & dosage</topic><topic>Flavonoids - therapeutic use</topic><topic>human health</topic><topic>hypercholesterolemia</topic><topic>Lipid Metabolism - drug effects</topic><topic>Lipids - blood</topic><topic>Liver - drug effects</topic><topic>Male</topic><topic>Malus - chemistry</topic><topic>Organ Size - drug effects</topic><topic>Phenols - administration & dosage</topic><topic>Phenols - therapeutic use</topic><topic>Polyphenols</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Steroids</topic><topic>Steroids - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Osada, K</creatorcontrib><creatorcontrib>Suzuki, T</creatorcontrib><creatorcontrib>Kawakami, Y</creatorcontrib><creatorcontrib>Senda, M</creatorcontrib><creatorcontrib>Kasai, A</creatorcontrib><creatorcontrib>Sami, M</creatorcontrib><creatorcontrib>Ohta, Y</creatorcontrib><creatorcontrib>Kanda, T</creatorcontrib><creatorcontrib>Ikeda, M</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Earth, Atmospheric & Aquatic Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Earth, Atmospheric & Aquatic Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Lipids</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Osada, K</au><au>Suzuki, T</au><au>Kawakami, Y</au><au>Senda, M</au><au>Kasai, A</au><au>Sami, M</au><au>Ohta, Y</au><au>Kanda, T</au><au>Ikeda, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dose-dependent hypocholesterolemic actions of dietary apple polyphenol in rats fed cholesterol</atitle><jtitle>Lipids</jtitle><addtitle>Lipids</addtitle><date>2006-02</date><risdate>2006</risdate><volume>41</volume><issue>2</issue><spage>133</spage><epage>139</epage><pages>133-139</pages><issn>0024-4201</issn><eissn>1558-9307</eissn><abstract>The dose-dependent hypocholesterolemic and antiatherogenic effects of dietary apple polyphenol (AP) from unripe apple, which contains approximately 85% catechin oligomers (procyanidins), were examined in male Sprague-Dawley rats (4 wk of age) given a purified diet containing 0.5% cholesterol. Dietary AP at 0.5 and 1.0% levels significantly decreased the liver cholesterol level compared with that in the control (AP-free dietfed) group. Dietary AP also significantly lowered the serum cholesterol level compared with that in the control group. However, the HDL cholesterol level was significantly higher in the 1.0% AP fed group than in the control group. Accordingly, the ratio of HDL-cholesterol/total cholesterol was significantly higher in the 0.5% AP-fed group and 1.0% AP-fed group than in the control group. Moreover, the atherogenic indices in the 0.5 and 1.0% AP-fed groups were significantly lower than those in the control group. The activity of hepatic cholesterol 7α-hydroxylase tended to be increased by dietary AP in a dose-dependent manner. In accord with this observation, dietary AP increased the excretion of acidic steroids in feces. Dietary AP also significantly promoted the fecal excretion of neutral steroids in a dose-dependent manner. These observations suggest that dietary AP at 0.5 or 1.0% level exerts hypocholesterolemic and antiatherogenic effects through the promotion of cholesterol catabolism and inhibition of intestinal absorption of cholesterol.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer‐Verlag</pub><pmid>17707979</pmid><doi>10.1007/s11745-006-5081-y</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0024-4201 |
| ispartof | Lipids, 2006-02, Vol.41 (2), p.133-139 |
| issn | 0024-4201 1558-9307 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_68348603 |
| source | MEDLINE; Wiley Online Library All Journals; SpringerLink Journals - AutoHoldings |
| subjects | animal disease models Animals Anticholesteremic Agents - administration & dosage Anticholesteremic Agents - therapeutic use Apples blood serum Body Weight - drug effects catechin Cholesterol Cholesterol 7-alpha-Hydroxylase - metabolism Cholesterol, Dietary dietary supplements disease control Excretion Feces - chemistry Flavonoids - administration & dosage Flavonoids - therapeutic use human health hypercholesterolemia Lipid Metabolism - drug effects Lipids - blood Liver - drug effects Male Malus - chemistry Organ Size - drug effects Phenols - administration & dosage Phenols - therapeutic use Polyphenols Rats Rats, Sprague-Dawley Steroids Steroids - metabolism |
| title | Dose-dependent hypocholesterolemic actions of dietary apple polyphenol in rats fed cholesterol |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-08T04%3A40%3A20IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Dose-dependent%20hypocholesterolemic%20actions%20of%20dietary%20apple%20polyphenol%20in%20rats%20fed%20cholesterol&rft.jtitle=Lipids&rft.au=Osada,%20K&rft.date=2006-02&rft.volume=41&rft.issue=2&rft.spage=133&rft.epage=139&rft.pages=133-139&rft.issn=0024-4201&rft.eissn=1558-9307&rft_id=info:doi/10.1007/s11745-006-5081-y&rft_dat=%3Cproquest_cross%3E68348603%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=274753562&rft_id=info:pmid/17707979&rfr_iscdi=true |