Lobectomy for treating bronchial carcinoma: analysis of comorbidities and their impact on postoperative morbidity and mortality
To analyze the impact that comorbidities have on the postoperative outcomes in patients submitted to lobectomy for the treatment of bronchial carcinoma. A retrospective study of 493 patients submitted to lobectomy for the treatment of bronchial carcinoma was conducted, and 305 of those patients met...
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| Veröffentlicht in: | Jornal brasileiro de pneumologia 2006-11, Vol.32 (6), p.495-504 |
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| creator | Sánchez, Pablo Gerardo Vendrame, Giovani Schirmer Madke, Gabriel Ribeiro Pilla, Eduardo Sperb Camargo, José de Jesus Peixoto Andrade, Cristiano Feijó Felicetti, José Carlos Cardoso, Paulo Francisco Guerreiro |
| description | To analyze the impact that comorbidities have on the postoperative outcomes in patients submitted to lobectomy for the treatment of bronchial carcinoma.
A retrospective study of 493 patients submitted to lobectomy for the treatment of bronchial carcinoma was conducted, and 305 of those patients met the criteria for inclusion in the final study sample. The surgical technique used was similar in all cases. The Torrington-Henderson scale and the Charlson scale were used to analyze comorbidities and to categorize patients into groups based on degree of risk for postoperative complications or death.
The postoperative (30-day) mortality rate was 2.9%, and the postoperative complications index was 44%. Prolonged air leakage was the most common complication (in 20.6%). The univariate analysis revealed that gender, age, smoking, neoadjuvant therapy and diabetes all had a significant impact on the incidence of complications. The factors found to be predictive of complications were body mass index (23.8 +/- 4.4), forced expiratory volume in one second (74.1 +/- 24%) and the ratio between forced expiratory volume in one second and forced vital capacity (0.65 +/- 0.1). The scales employed proved efficacious in the identification of the risk groups, as well as in drawing correlations with morbidity and mortality (p = 0.001 and p < 0.001). In the multivariate analysis, body mass index and the Charlson index were found to be the principal determinants of complications. In addition, prolonged air leakage was found to be the principal factor involved in mortality (p = 0.01).
Reductions in forced expiratory volume in one second, in the ratio between forced expiratory volume in one second and forced vital capacity, and in body mass index, as well as a Charlson score of 3 or 4 and a Torrington-Henderson score of 3, were associated with a greater number of postoperative complications in patients submitted to lobectomy for the treatment of bronchial carcinoma. Air leakage was found to be strongly associated with mortality. |
| format | Article |
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A retrospective study of 493 patients submitted to lobectomy for the treatment of bronchial carcinoma was conducted, and 305 of those patients met the criteria for inclusion in the final study sample. The surgical technique used was similar in all cases. The Torrington-Henderson scale and the Charlson scale were used to analyze comorbidities and to categorize patients into groups based on degree of risk for postoperative complications or death.
The postoperative (30-day) mortality rate was 2.9%, and the postoperative complications index was 44%. Prolonged air leakage was the most common complication (in 20.6%). The univariate analysis revealed that gender, age, smoking, neoadjuvant therapy and diabetes all had a significant impact on the incidence of complications. The factors found to be predictive of complications were body mass index (23.8 +/- 4.4), forced expiratory volume in one second (74.1 +/- 24%) and the ratio between forced expiratory volume in one second and forced vital capacity (0.65 +/- 0.1). The scales employed proved efficacious in the identification of the risk groups, as well as in drawing correlations with morbidity and mortality (p = 0.001 and p < 0.001). In the multivariate analysis, body mass index and the Charlson index were found to be the principal determinants of complications. In addition, prolonged air leakage was found to be the principal factor involved in mortality (p = 0.01).
Reductions in forced expiratory volume in one second, in the ratio between forced expiratory volume in one second and forced vital capacity, and in body mass index, as well as a Charlson score of 3 or 4 and a Torrington-Henderson score of 3, were associated with a greater number of postoperative complications in patients submitted to lobectomy for the treatment of bronchial carcinoma. Air leakage was found to be strongly associated with mortality.</description><identifier>EISSN: 1806-3756</identifier><identifier>PMID: 17435899</identifier><language>eng ; por</language><publisher>Brazil</publisher><subject>Aged ; Carcinoma, Bronchogenic - mortality ; Carcinoma, Bronchogenic - surgery ; Comorbidity ; Epidemiologic Methods ; Female ; Humans ; Lung Neoplasms - mortality ; Lung Neoplasms - surgery ; Male ; Middle Aged ; Pneumonectomy - mortality ; Postoperative Complications - mortality</subject><ispartof>Jornal brasileiro de pneumologia, 2006-11, Vol.32 (6), p.495-504</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17435899$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sánchez, Pablo Gerardo</creatorcontrib><creatorcontrib>Vendrame, Giovani Schirmer</creatorcontrib><creatorcontrib>Madke, Gabriel Ribeiro</creatorcontrib><creatorcontrib>Pilla, Eduardo Sperb</creatorcontrib><creatorcontrib>Camargo, José de Jesus Peixoto</creatorcontrib><creatorcontrib>Andrade, Cristiano Feijó</creatorcontrib><creatorcontrib>Felicetti, José Carlos</creatorcontrib><creatorcontrib>Cardoso, Paulo Francisco Guerreiro</creatorcontrib><title>Lobectomy for treating bronchial carcinoma: analysis of comorbidities and their impact on postoperative morbidity and mortality</title><title>Jornal brasileiro de pneumologia</title><addtitle>J Bras Pneumol</addtitle><description>To analyze the impact that comorbidities have on the postoperative outcomes in patients submitted to lobectomy for the treatment of bronchial carcinoma.
A retrospective study of 493 patients submitted to lobectomy for the treatment of bronchial carcinoma was conducted, and 305 of those patients met the criteria for inclusion in the final study sample. The surgical technique used was similar in all cases. The Torrington-Henderson scale and the Charlson scale were used to analyze comorbidities and to categorize patients into groups based on degree of risk for postoperative complications or death.
The postoperative (30-day) mortality rate was 2.9%, and the postoperative complications index was 44%. Prolonged air leakage was the most common complication (in 20.6%). The univariate analysis revealed that gender, age, smoking, neoadjuvant therapy and diabetes all had a significant impact on the incidence of complications. The factors found to be predictive of complications were body mass index (23.8 +/- 4.4), forced expiratory volume in one second (74.1 +/- 24%) and the ratio between forced expiratory volume in one second and forced vital capacity (0.65 +/- 0.1). The scales employed proved efficacious in the identification of the risk groups, as well as in drawing correlations with morbidity and mortality (p = 0.001 and p < 0.001). In the multivariate analysis, body mass index and the Charlson index were found to be the principal determinants of complications. In addition, prolonged air leakage was found to be the principal factor involved in mortality (p = 0.01).
Reductions in forced expiratory volume in one second, in the ratio between forced expiratory volume in one second and forced vital capacity, and in body mass index, as well as a Charlson score of 3 or 4 and a Torrington-Henderson score of 3, were associated with a greater number of postoperative complications in patients submitted to lobectomy for the treatment of bronchial carcinoma. Air leakage was found to be strongly associated with mortality.</description><subject>Aged</subject><subject>Carcinoma, Bronchogenic - mortality</subject><subject>Carcinoma, Bronchogenic - surgery</subject><subject>Comorbidity</subject><subject>Epidemiologic Methods</subject><subject>Female</subject><subject>Humans</subject><subject>Lung Neoplasms - mortality</subject><subject>Lung Neoplasms - surgery</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Pneumonectomy - mortality</subject><subject>Postoperative Complications - mortality</subject><issn>1806-3756</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kM1KxDAYRYsgzjj6CpKVu0KbNH_uZPAPBtzMvnxNvziRpqlJRujKV7fozOpyuIe7uBfFulaVKJnkYlVcp_RZVVxoUV0Vq1o2jCut18XPLnRocvAzsSGSHBGyGz9IF8NoDg4GYiAaNwYPDwRGGObkEgmWmOBD7FzvssO0ND3JB3SROD-BySSMZAophwnjMviN5GzPf-5CGYaFbopLC0PC21Nuiv3z0377Wu7eX962j7ty4o0uBaAFi8poi5KymiJoBYIq2wAKLXnXay4kWou604ZKyyqgHbO1ZYqjZJvi_n92iuHriCm33iWDwwAjhmNqhWINp1Qt4t1JPHYe-3aKzkOc2_Nj7Be822sp</recordid><startdate>200611</startdate><enddate>200611</enddate><creator>Sánchez, Pablo Gerardo</creator><creator>Vendrame, Giovani Schirmer</creator><creator>Madke, Gabriel Ribeiro</creator><creator>Pilla, Eduardo Sperb</creator><creator>Camargo, José de Jesus Peixoto</creator><creator>Andrade, Cristiano Feijó</creator><creator>Felicetti, José Carlos</creator><creator>Cardoso, Paulo Francisco Guerreiro</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>200611</creationdate><title>Lobectomy for treating bronchial carcinoma: analysis of comorbidities and their impact on postoperative morbidity and mortality</title><author>Sánchez, Pablo Gerardo ; Vendrame, Giovani Schirmer ; Madke, Gabriel Ribeiro ; Pilla, Eduardo Sperb ; Camargo, José de Jesus Peixoto ; Andrade, Cristiano Feijó ; Felicetti, José Carlos ; Cardoso, Paulo Francisco Guerreiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p549-6aefafe8c9fe72312ea98a628f4ae6975bd9567effe9b9c27f30a2b3f1f385e73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng ; por</language><creationdate>2006</creationdate><topic>Aged</topic><topic>Carcinoma, Bronchogenic - mortality</topic><topic>Carcinoma, Bronchogenic - surgery</topic><topic>Comorbidity</topic><topic>Epidemiologic Methods</topic><topic>Female</topic><topic>Humans</topic><topic>Lung Neoplasms - mortality</topic><topic>Lung Neoplasms - surgery</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Pneumonectomy - mortality</topic><topic>Postoperative Complications - mortality</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sánchez, Pablo Gerardo</creatorcontrib><creatorcontrib>Vendrame, Giovani Schirmer</creatorcontrib><creatorcontrib>Madke, Gabriel Ribeiro</creatorcontrib><creatorcontrib>Pilla, Eduardo Sperb</creatorcontrib><creatorcontrib>Camargo, José de Jesus Peixoto</creatorcontrib><creatorcontrib>Andrade, Cristiano Feijó</creatorcontrib><creatorcontrib>Felicetti, José Carlos</creatorcontrib><creatorcontrib>Cardoso, Paulo Francisco Guerreiro</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Jornal brasileiro de pneumologia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sánchez, Pablo Gerardo</au><au>Vendrame, Giovani Schirmer</au><au>Madke, Gabriel Ribeiro</au><au>Pilla, Eduardo Sperb</au><au>Camargo, José de Jesus Peixoto</au><au>Andrade, Cristiano Feijó</au><au>Felicetti, José Carlos</au><au>Cardoso, Paulo Francisco Guerreiro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lobectomy for treating bronchial carcinoma: analysis of comorbidities and their impact on postoperative morbidity and mortality</atitle><jtitle>Jornal brasileiro de pneumologia</jtitle><addtitle>J Bras Pneumol</addtitle><date>2006-11</date><risdate>2006</risdate><volume>32</volume><issue>6</issue><spage>495</spage><epage>504</epage><pages>495-504</pages><eissn>1806-3756</eissn><abstract>To analyze the impact that comorbidities have on the postoperative outcomes in patients submitted to lobectomy for the treatment of bronchial carcinoma.
A retrospective study of 493 patients submitted to lobectomy for the treatment of bronchial carcinoma was conducted, and 305 of those patients met the criteria for inclusion in the final study sample. The surgical technique used was similar in all cases. The Torrington-Henderson scale and the Charlson scale were used to analyze comorbidities and to categorize patients into groups based on degree of risk for postoperative complications or death.
The postoperative (30-day) mortality rate was 2.9%, and the postoperative complications index was 44%. Prolonged air leakage was the most common complication (in 20.6%). The univariate analysis revealed that gender, age, smoking, neoadjuvant therapy and diabetes all had a significant impact on the incidence of complications. The factors found to be predictive of complications were body mass index (23.8 +/- 4.4), forced expiratory volume in one second (74.1 +/- 24%) and the ratio between forced expiratory volume in one second and forced vital capacity (0.65 +/- 0.1). The scales employed proved efficacious in the identification of the risk groups, as well as in drawing correlations with morbidity and mortality (p = 0.001 and p < 0.001). In the multivariate analysis, body mass index and the Charlson index were found to be the principal determinants of complications. In addition, prolonged air leakage was found to be the principal factor involved in mortality (p = 0.01).
Reductions in forced expiratory volume in one second, in the ratio between forced expiratory volume in one second and forced vital capacity, and in body mass index, as well as a Charlson score of 3 or 4 and a Torrington-Henderson score of 3, were associated with a greater number of postoperative complications in patients submitted to lobectomy for the treatment of bronchial carcinoma. Air leakage was found to be strongly associated with mortality.</abstract><cop>Brazil</cop><pmid>17435899</pmid><tpages>10</tpages></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals |
| subjects | Aged Carcinoma, Bronchogenic - mortality Carcinoma, Bronchogenic - surgery Comorbidity Epidemiologic Methods Female Humans Lung Neoplasms - mortality Lung Neoplasms - surgery Male Middle Aged Pneumonectomy - mortality Postoperative Complications - mortality |
| title | Lobectomy for treating bronchial carcinoma: analysis of comorbidities and their impact on postoperative morbidity and mortality |
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