Loss of TP53-DNA interaction induced by p.C135R in lung cancer

The p53 tumor suppressor gene (TP53; OMIM: 191170) plays an important role in tumorigenesis in lung epithelial cells. TP53 encodes a sequence-specific DNA-binding protein that regulates transcription of several genes in response to DNA damage promoting cell cycle arrest, DNA repair or apoptosis. A m...

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Veröffentlicht in:	Oncology reports 2007-11, Vol.18 (5), p.1213-1217
Hauptverfasser:	ARANDA, Marcela, GONZALEZ-NILO, Fernando, RIADI, Gonzalo, DIAZ, Victor, PEREZ, Jose, MARTEL, Ghyslaine, HAINAUT, Pierre, MIMBACAS, Adriana
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding, Competitive Biological and medical sciences Carcinoma, Non-Small-Cell Lung - genetics Carcinoma, Non-Small-Cell Lung - metabolism Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - metabolism DNA, Neoplasm - genetics DNA, Neoplasm - metabolism Electrophoretic Mobility Shift Assay Escherichia coli - growth & development Escherichia coli - metabolism Humans Lung Neoplasms - genetics Lung Neoplasms - metabolism Medical sciences Pneumology Point Mutation - genetics Polymerase Chain Reaction Saccharomyces cerevisiae - growth & development Saccharomyces cerevisiae - metabolism Static Electricity Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism Tumors Tumors of the respiratory system and mediastinum
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