Collecting duct epithelium and injury: Not all cells are created equal

Studies by Butt et al. in the developing fetus provide new and timely insights into the regulation of repair and fibrosis in the injured kidney. Using a clinically relevant model, they have examined the response of the medullary collecting duct to ureteral obstruction, with some unexpected findings.

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Bibliographische Detailangaben
Veröffentlicht in:	Kidney international 2007-10, Vol.72 (8), p.914-915
1. Verfasser:	Hewitson, T.D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aquaporin 2 - metabolism Carbonic Anhydrase II - metabolism Cell Communication - physiology Cell Differentiation - physiology Cell Movement - physiology Disease Models, Animal Epithelial Cells - metabolism Epithelial Cells - pathology Female Fibrosis Kidney Medulla - embryology Kidney Medulla - metabolism Kidney Medulla - pathology Kidney Tubules, Collecting - embryology Kidney Tubules, Collecting - metabolism Kidney Tubules, Collecting - pathology Macaca mulatta Mesoderm - metabolism Mesoderm - pathology Pregnancy Ureteral Obstruction - metabolism Ureteral Obstruction - pathology
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Beschreibung
Zusammenfassung:	Studies by Butt et al. in the developing fetus provide new and timely insights into the regulation of repair and fibrosis in the injured kidney. Using a clinically relevant model, they have examined the response of the medullary collecting duct to ureteral obstruction, with some unexpected findings.
ISSN:	0085-2538 1523-1755
DOI:	10.1038/sj.ki.5002508