Rho/Rho kinase is a key enzyme system involved in the angiotensin II signaling pathway of liver fibrosis and steatosis

Background and Aim: The molecular mechanisms underlying the involvement of the renin‐angiotensin system in hepatic fibrosis are unclear. Recently, it was reported that a Rho kinase inhibitor prevented fibrosis of various tissues and that the Rho/Rho kinase pathway was involved in the renin‐angioten...

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Veröffentlicht in:	Journal of gastroenterology and hepatology 2007-11, Vol.22 (11), p.2022-2033
Hauptverfasser:	Kitamura, Kumi, Tada, Shinichiro, Nakamoto, Nobuhiro, Toda, Kyoko, Horikawa, Hitomi, Kurita, Satoshi, Tsunematsu, Satoshi, Kumagai, Naoki, Ishii, Hiromasa, Saito, Hidetsugu, Hibi, Toshifumi
Format:	Artikel
Sprache:	eng
Schlagworte:	Alanine Transaminase - blood Amides - pharmacology Amides - therapeutic use Angiotensin II - metabolism Angiotensin II Type 1 Receptor Blockers - pharmacology Angiotensin II Type 1 Receptor Blockers - therapeutic use Animals Aspartate Aminotransferases - blood Benzimidazoles - pharmacology Benzimidazoles - therapeutic use Biological and medical sciences Biphenyl Compounds - pharmacology Biphenyl Compounds - therapeutic use Cells, Cultured Choline Deficiency - complications Choline Deficiency - enzymology Choline Deficiency - metabolism Choline Deficiency - pathology Disease Models, Animal DNA Damage Fatty Liver - drug therapy Fatty Liver - enzymology Fatty Liver - etiology Fatty Liver - metabolism Fatty Liver - pathology free radical Gastroenterology. Liver. Pancreas. Abdomen hepatic fibrosis hepatic stellate cells Liver - drug effects Liver - enzymology Liver - metabolism Liver Cirrhosis - drug therapy Liver Cirrhosis - enzymology Liver Cirrhosis - etiology Liver Cirrhosis - metabolism Liver Cirrhosis - pathology Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Medical sciences Organ Size Other diseases. Semiology Oxidative Stress Protein Kinase Inhibitors - pharmacology Protein Kinase Inhibitors - therapeutic use Pyridines - pharmacology Pyridines - therapeutic use Rats Rats, Wistar Reactive Oxygen Species - metabolism renin-angiotensin system rho GTP-Binding Proteins - metabolism rho-Associated Kinases - antagonists & inhibitors rho-Associated Kinases - metabolism Rho/Rho kinase system RNA, Messenger - metabolism Signal Transduction - drug effects Tetrazoles - pharmacology Tetrazoles - therapeutic use Time Factors Tumor Necrosis Factor-alpha - genetics Tumor Necrosis Factor-alpha - metabolism
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