Assessing Bias in Experiment Design for Large Scale Mass Spectrometry-based Quantitative Proteomics

Mass spectrometry-based proteomics holds great promise as a discovery tool for biomarker candidates in the early detection of diseases. Recently much emphasis has been placed upon producing highly reliable data for quantitative profiling for which highly reproducible methodologies are indispensable....

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Veröffentlicht in:	Molecular & cellular proteomics 2007-10, Vol.6 (10), p.1741-1748
Hauptverfasser:	Prakash, Amol, Piening, Brian, Whiteaker, Jeff, Zhang, Heidi, Shaffer, Scott A., Martin, Daniel, Hohmann, Laura, Cooke, Kelly, Olson, James M., Hansen, Stacey, Flory, Mark R., Lee, Hookeun, Watts, Julian, Goodlett, David R., Aebersold, Ruedi, Paulovich, Amanda, Schwikowski, Benno
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin II - pharmacology Animals Bias Biomarkers - metabolism Cell Cycle - drug effects Chromatography, Liquid Disease Models, Animal Freezing Humans Huntington Disease - metabolism Mass Spectrometry Mice Proteomics - methods Reproducibility of Results Research Design Saccharomyces cerevisiae - cytology Saccharomyces cerevisiae - drug effects Time Factors
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