Resveratrol induces pro-apoptotic endoplasmic reticulum stress in human colon cancer cells
Resveratrol (3,4',5 tri-hydroxystilbene), a naturally occurring polyphenolic compound highly enriched in grapes and red wine, has been shown to induce anti-proliferation and apoptosis of human cancer cell lines. Resveratrol-induced dose-dependent apoptotic cell death in colon carcinoma cells, w...
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| Veröffentlicht in: | Oncology reports 2007-11, Vol.18 (5), p.1269-1273 |
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| container_title | Oncology reports |
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| creator | PARK, Jong-Wook KYUNG JIN WOO LEE, Jung-Tae JUN HEE LIM LEE, Tae-Jin SANG HYUN KIM YUNG HYUN CHOI TAEG KYU KWON |
| description | Resveratrol (3,4',5 tri-hydroxystilbene), a naturally occurring polyphenolic compound highly enriched in grapes and red wine, has been shown to induce anti-proliferation and apoptosis of human cancer cell lines. Resveratrol-induced dose-dependent apoptotic cell death in colon carcinoma cells, was measured by FACS analysis. Treatment of HT29 human colon carcinoma cells with resveratrol was found to induce a number of signature ER stress markers; phosphorylation of eukaryotic initiation factor-2alpha (eIF-2alpha), ER stress-specific XBP1 splicing and CCAAT/enhancer-binding protein-homologous protein (CHOP). In addition, resveratrol induced up-regulation of glucose-regulated protein (GRP)-78, suggesting the induction of ER stress. Furthermore, the inhibition of caspase-4 activity by z-LEVD-fmk significantly reduced resveratrol-induced apoptosis. Taken together, the present study therefore provides strong evidence to support an important role of ER stress response in mediating the resveratrol-induced apoptosis. |
| doi_str_mv | 10.3892/or.18.5.1269 |
| format | Article |
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Resveratrol-induced dose-dependent apoptotic cell death in colon carcinoma cells, was measured by FACS analysis. Treatment of HT29 human colon carcinoma cells with resveratrol was found to induce a number of signature ER stress markers; phosphorylation of eukaryotic initiation factor-2alpha (eIF-2alpha), ER stress-specific XBP1 splicing and CCAAT/enhancer-binding protein-homologous protein (CHOP). In addition, resveratrol induced up-regulation of glucose-regulated protein (GRP)-78, suggesting the induction of ER stress. Furthermore, the inhibition of caspase-4 activity by z-LEVD-fmk significantly reduced resveratrol-induced apoptosis. Taken together, the present study therefore provides strong evidence to support an important role of ER stress response in mediating the resveratrol-induced apoptosis.</description><identifier>ISSN: 1021-335X</identifier><identifier>EISSN: 1791-2431</identifier><identifier>DOI: 10.3892/or.18.5.1269</identifier><identifier>PMID: 17914584</identifier><language>eng</language><publisher>Athens: S.n.</publisher><subject>Anticarcinogenic Agents - pharmacology ; Apoptosis - drug effects ; Biological and medical sciences ; Blotting, Western ; Caspases - metabolism ; Colonic Neoplasms - drug therapy ; Colonic Neoplasms - metabolism ; DNA-Binding Proteins - genetics ; Endoplasmic Reticulum - drug effects ; Endoplasmic Reticulum - metabolism ; Eukaryotic Initiation Factor-2 - genetics ; Eukaryotic Initiation Factor-2 - metabolism ; Flow Cytometry ; Gastroenterology. Liver. Pancreas. Abdomen ; Heat-Shock Proteins - genetics ; Heat-Shock Proteins - metabolism ; HT29 Cells - drug effects ; Humans ; Medical sciences ; Molecular Chaperones - genetics ; Molecular Chaperones - metabolism ; Nuclear Proteins - genetics ; Phosphorylation - drug effects ; Regulatory Factor X Transcription Factors ; Reverse Transcriptase Polymerase Chain Reaction ; RNA, Messenger - genetics ; RNA, Messenger - metabolism ; Stilbenes - pharmacology ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Transcription Factor CHOP - genetics ; Transcription Factor CHOP - metabolism ; Transcription Factors ; Tumors ; X-Box Binding Protein 1</subject><ispartof>Oncology reports, 2007-11, Vol.18 (5), p.1269-1273</ispartof><rights>2007 INIST-CNRS</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-fb0dbfaa555786385504184efd2fa81b6f02f156fa27d95f52c3d358d22337573</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19189402$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17914584$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>PARK, Jong-Wook</creatorcontrib><creatorcontrib>KYUNG JIN WOO</creatorcontrib><creatorcontrib>LEE, Jung-Tae</creatorcontrib><creatorcontrib>JUN HEE LIM</creatorcontrib><creatorcontrib>LEE, Tae-Jin</creatorcontrib><creatorcontrib>SANG HYUN KIM</creatorcontrib><creatorcontrib>YUNG HYUN CHOI</creatorcontrib><creatorcontrib>TAEG KYU KWON</creatorcontrib><title>Resveratrol induces pro-apoptotic endoplasmic reticulum stress in human colon cancer cells</title><title>Oncology reports</title><addtitle>Oncol Rep</addtitle><description>Resveratrol (3,4',5 tri-hydroxystilbene), a naturally occurring polyphenolic compound highly enriched in grapes and red wine, has been shown to induce anti-proliferation and apoptosis of human cancer cell lines. Resveratrol-induced dose-dependent apoptotic cell death in colon carcinoma cells, was measured by FACS analysis. Treatment of HT29 human colon carcinoma cells with resveratrol was found to induce a number of signature ER stress markers; phosphorylation of eukaryotic initiation factor-2alpha (eIF-2alpha), ER stress-specific XBP1 splicing and CCAAT/enhancer-binding protein-homologous protein (CHOP). In addition, resveratrol induced up-regulation of glucose-regulated protein (GRP)-78, suggesting the induction of ER stress. Furthermore, the inhibition of caspase-4 activity by z-LEVD-fmk significantly reduced resveratrol-induced apoptosis. Taken together, the present study therefore provides strong evidence to support an important role of ER stress response in mediating the resveratrol-induced apoptosis.</description><subject>Anticarcinogenic Agents - pharmacology</subject><subject>Apoptosis - drug effects</subject><subject>Biological and medical sciences</subject><subject>Blotting, Western</subject><subject>Caspases - metabolism</subject><subject>Colonic Neoplasms - drug therapy</subject><subject>Colonic Neoplasms - metabolism</subject><subject>DNA-Binding Proteins - genetics</subject><subject>Endoplasmic Reticulum - drug effects</subject><subject>Endoplasmic Reticulum - metabolism</subject><subject>Eukaryotic Initiation Factor-2 - genetics</subject><subject>Eukaryotic Initiation Factor-2 - metabolism</subject><subject>Flow Cytometry</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Heat-Shock Proteins - genetics</subject><subject>Heat-Shock Proteins - metabolism</subject><subject>HT29 Cells - drug effects</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Molecular Chaperones - genetics</subject><subject>Molecular Chaperones - metabolism</subject><subject>Nuclear Proteins - genetics</subject><subject>Phosphorylation - drug effects</subject><subject>Regulatory Factor X Transcription Factors</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>RNA, Messenger - genetics</subject><subject>RNA, Messenger - metabolism</subject><subject>Stilbenes - pharmacology</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</subject><subject>Transcription Factor CHOP - genetics</subject><subject>Transcription Factor CHOP - metabolism</subject><subject>Transcription Factors</subject><subject>Tumors</subject><subject>X-Box Binding Protein 1</subject><issn>1021-335X</issn><issn>1791-2431</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkM1LxDAQxYMo7rp68yy96MnWfDRtepTFL1gQREG8hDRNsJI2NdMK_vembMHLm2H4zWPmIXROcMZERW98yIjIeEZoUR2gNSkrktKckcPYY0pSxvj7Cp0AfGFMS1xUx2g1QzkX-Rp9vBj4MUGNwbuk7ZtJG0iG4FM1-GH0Y6sT0zd-cAq62AcTJ5ObugTGYADiSvI5dapPtHc-quq1CYk2zsEpOrLKgTlb6ga93d-9bh_T3fPD0_Z2l2rGyzG1NW5qqxTnvBQFE5zjnIjc2IZaJUhdWEwt4YVVtGwqbjnVrGFcNJQyVvKSbdDV3jee_T0ZGGXXwnyB6o2fQBaC5biKukHXe1AHDxCMlUNoOxV-JcFyzlL6IImQXM5ZRvxi8Z3qzjT_8BJeBC4XQIFWzob4fAv_XEVElWPK_gA46X2t</recordid><startdate>20071101</startdate><enddate>20071101</enddate><creator>PARK, Jong-Wook</creator><creator>KYUNG JIN WOO</creator><creator>LEE, Jung-Tae</creator><creator>JUN HEE LIM</creator><creator>LEE, Tae-Jin</creator><creator>SANG HYUN KIM</creator><creator>YUNG HYUN CHOI</creator><creator>TAEG KYU KWON</creator><general>S.n.</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20071101</creationdate><title>Resveratrol induces pro-apoptotic endoplasmic reticulum stress in human colon cancer cells</title><author>PARK, Jong-Wook ; KYUNG JIN WOO ; LEE, Jung-Tae ; JUN HEE LIM ; LEE, Tae-Jin ; SANG HYUN KIM ; YUNG HYUN CHOI ; TAEG KYU KWON</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-fb0dbfaa555786385504184efd2fa81b6f02f156fa27d95f52c3d358d22337573</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Anticarcinogenic Agents - pharmacology</topic><topic>Apoptosis - drug effects</topic><topic>Biological and medical sciences</topic><topic>Blotting, Western</topic><topic>Caspases - metabolism</topic><topic>Colonic Neoplasms - drug therapy</topic><topic>Colonic Neoplasms - metabolism</topic><topic>DNA-Binding Proteins - genetics</topic><topic>Endoplasmic Reticulum - drug effects</topic><topic>Endoplasmic Reticulum - metabolism</topic><topic>Eukaryotic Initiation Factor-2 - genetics</topic><topic>Eukaryotic Initiation Factor-2 - metabolism</topic><topic>Flow Cytometry</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Heat-Shock Proteins - genetics</topic><topic>Heat-Shock Proteins - metabolism</topic><topic>HT29 Cells - drug effects</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Molecular Chaperones - genetics</topic><topic>Molecular Chaperones - metabolism</topic><topic>Nuclear Proteins - genetics</topic><topic>Phosphorylation - drug effects</topic><topic>Regulatory Factor X Transcription Factors</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><topic>RNA, Messenger - genetics</topic><topic>RNA, Messenger - metabolism</topic><topic>Stilbenes - pharmacology</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><topic>Transcription Factor CHOP - genetics</topic><topic>Transcription Factor CHOP - metabolism</topic><topic>Transcription Factors</topic><topic>Tumors</topic><topic>X-Box Binding Protein 1</topic><toplevel>online_resources</toplevel><creatorcontrib>PARK, Jong-Wook</creatorcontrib><creatorcontrib>KYUNG JIN WOO</creatorcontrib><creatorcontrib>LEE, Jung-Tae</creatorcontrib><creatorcontrib>JUN HEE LIM</creatorcontrib><creatorcontrib>LEE, Tae-Jin</creatorcontrib><creatorcontrib>SANG HYUN KIM</creatorcontrib><creatorcontrib>YUNG HYUN CHOI</creatorcontrib><creatorcontrib>TAEG KYU KWON</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Oncology reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>PARK, Jong-Wook</au><au>KYUNG JIN WOO</au><au>LEE, Jung-Tae</au><au>JUN HEE LIM</au><au>LEE, Tae-Jin</au><au>SANG HYUN KIM</au><au>YUNG HYUN CHOI</au><au>TAEG KYU KWON</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Resveratrol induces pro-apoptotic endoplasmic reticulum stress in human colon cancer cells</atitle><jtitle>Oncology reports</jtitle><addtitle>Oncol Rep</addtitle><date>2007-11-01</date><risdate>2007</risdate><volume>18</volume><issue>5</issue><spage>1269</spage><epage>1273</epage><pages>1269-1273</pages><issn>1021-335X</issn><eissn>1791-2431</eissn><abstract>Resveratrol (3,4',5 tri-hydroxystilbene), a naturally occurring polyphenolic compound highly enriched in grapes and red wine, has been shown to induce anti-proliferation and apoptosis of human cancer cell lines. 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| subjects | Anticarcinogenic Agents - pharmacology Apoptosis - drug effects Biological and medical sciences Blotting, Western Caspases - metabolism Colonic Neoplasms - drug therapy Colonic Neoplasms - metabolism DNA-Binding Proteins - genetics Endoplasmic Reticulum - drug effects Endoplasmic Reticulum - metabolism Eukaryotic Initiation Factor-2 - genetics Eukaryotic Initiation Factor-2 - metabolism Flow Cytometry Gastroenterology. Liver. Pancreas. Abdomen Heat-Shock Proteins - genetics Heat-Shock Proteins - metabolism HT29 Cells - drug effects Humans Medical sciences Molecular Chaperones - genetics Molecular Chaperones - metabolism Nuclear Proteins - genetics Phosphorylation - drug effects Regulatory Factor X Transcription Factors Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics RNA, Messenger - metabolism Stilbenes - pharmacology Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Transcription Factor CHOP - genetics Transcription Factor CHOP - metabolism Transcription Factors Tumors X-Box Binding Protein 1 |
| title | Resveratrol induces pro-apoptotic endoplasmic reticulum stress in human colon cancer cells |
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