High nerve growth factor receptor (p75NTR) expression is a favourable prognostic factor in paediatric B cell precursor‐acute lymphoblastic leukaemia
Summary Nerve growth factor (NGF) plays a pivotal role in cellular survival/death decisions with the low affinity receptor p75NTR predominately transmitting anti‐proliferative signals. In spite of its established role in B‐cell function and identification as a prognostically favourable marker in a n...
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| Veröffentlicht in: | British journal of haematology 2007-11, Vol.139 (3), p.450-457 |
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| creator | Troeger, Anja Gudowius, Sonja Escherich, Gabriele Den Boer, Monique L. Glouchkova, Ludmila Ackermann, Birgit Meisel, Roland Laws, Hans‐Juergen Groeger, Marketa Wessalowski, Ruediger Willers, Reinhart Harbott, Jochen Pieters, Rob Goebel, Ulrich Janka‐Schaub, Gritta E. Hanenberg, Helmut Dilloo, Dagmar |
| description | Summary
Nerve growth factor (NGF) plays a pivotal role in cellular survival/death decisions with the low affinity receptor p75NTR predominately transmitting anti‐proliferative signals. In spite of its established role in B‐cell function and identification as a prognostically favourable marker in a number of malignancies, little is known about the expression pattern and prognostic significance of p75NTR in B cell precursor‐acute lymphoblastic leukaemia (BCP‐ALL). p75NTR expression was prospectively studied on primary ALL‐blasts in a cohort of paediatric patients with common ALL (n = 86) and preB‐ALL (n = 34) treated within the Co‐operative study group for childhood acute lymphoblastic leukaemia (CoALL) protocol, CoALL06‐97. Flow cytometric analysis showed that almost half of the patients expressed no or negligible amounts of p75NTR ( |
| doi_str_mv | 10.1111/j.1365-2141.2007.06818.x |
| format | Article |
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Nerve growth factor (NGF) plays a pivotal role in cellular survival/death decisions with the low affinity receptor p75NTR predominately transmitting anti‐proliferative signals. In spite of its established role in B‐cell function and identification as a prognostically favourable marker in a number of malignancies, little is known about the expression pattern and prognostic significance of p75NTR in B cell precursor‐acute lymphoblastic leukaemia (BCP‐ALL). p75NTR expression was prospectively studied on primary ALL‐blasts in a cohort of paediatric patients with common ALL (n = 86) and preB‐ALL (n = 34) treated within the Co‐operative study group for childhood acute lymphoblastic leukaemia (CoALL) protocol, CoALL06‐97. Flow cytometric analysis showed that almost half of the patients expressed no or negligible amounts of p75NTR (<10%). The median expression in patients expressing p75NTR beyond that threshold was 49% (range 11–100%). In patients classified as low‐risk at diagnosis, p75NTR expression was significantly higher than in high‐risk patients (P = 0·001). Of note, p75NTR expression was lower in the 21 patients who subsequently developed relapse compared with those remaining in remission (P = 0·038). Accordingly, relapse‐free survival was significantly better in patients expressing high surface p75NTR (P = 0·041). Thus, in this prospective analysis, high p75NTR expression was a strong prognostic marker that identified a group of paediatric ALL patients with favourable outcome.</description><identifier>ISSN: 0007-1048</identifier><identifier>EISSN: 1365-2141</identifier><identifier>DOI: 10.1111/j.1365-2141.2007.06818.x</identifier><identifier>PMID: 17910636</identifier><identifier>CODEN: BJHEAL</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adolescent ; B cell precursor‐acute lymphoblastic leukaemia ; Biological and medical sciences ; Biomarkers, Tumor - metabolism ; Child ; Child, Preschool ; children ; Female ; Flow Cytometry ; Hematologic and hematopoietic diseases ; Humans ; Infant ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Leukocyte Count ; Male ; Medical sciences ; Neoplasm Proteins - blood ; Nerve Tissue Proteins - blood ; p75NTR ; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - blood ; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - therapy ; Prognosis ; Prospective Studies ; Receptors, Nerve Growth Factor - blood ; Survival Analysis ; Treatment Outcome</subject><ispartof>British journal of haematology, 2007-11, Vol.139 (3), p.450-457</ispartof><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4288-93c500cf01322820e7d0f0c78e6eeed6b136577c9ba4c93564be45aa9c4cc0bb3</citedby><cites>FETCH-LOGICAL-c4288-93c500cf01322820e7d0f0c78e6eeed6b136577c9ba4c93564be45aa9c4cc0bb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-2141.2007.06818.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-2141.2007.06818.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,1427,27901,27902,45550,45551,46384,46808</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19156131$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17910636$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Troeger, Anja</creatorcontrib><creatorcontrib>Gudowius, Sonja</creatorcontrib><creatorcontrib>Escherich, Gabriele</creatorcontrib><creatorcontrib>Den Boer, Monique L.</creatorcontrib><creatorcontrib>Glouchkova, Ludmila</creatorcontrib><creatorcontrib>Ackermann, Birgit</creatorcontrib><creatorcontrib>Meisel, Roland</creatorcontrib><creatorcontrib>Laws, Hans‐Juergen</creatorcontrib><creatorcontrib>Groeger, Marketa</creatorcontrib><creatorcontrib>Wessalowski, Ruediger</creatorcontrib><creatorcontrib>Willers, Reinhart</creatorcontrib><creatorcontrib>Harbott, Jochen</creatorcontrib><creatorcontrib>Pieters, Rob</creatorcontrib><creatorcontrib>Goebel, Ulrich</creatorcontrib><creatorcontrib>Janka‐Schaub, Gritta E.</creatorcontrib><creatorcontrib>Hanenberg, Helmut</creatorcontrib><creatorcontrib>Dilloo, Dagmar</creatorcontrib><title>High nerve growth factor receptor (p75NTR) expression is a favourable prognostic factor in paediatric B cell precursor‐acute lymphoblastic leukaemia</title><title>British journal of haematology</title><addtitle>Br J Haematol</addtitle><description>Summary
Nerve growth factor (NGF) plays a pivotal role in cellular survival/death decisions with the low affinity receptor p75NTR predominately transmitting anti‐proliferative signals. In spite of its established role in B‐cell function and identification as a prognostically favourable marker in a number of malignancies, little is known about the expression pattern and prognostic significance of p75NTR in B cell precursor‐acute lymphoblastic leukaemia (BCP‐ALL). p75NTR expression was prospectively studied on primary ALL‐blasts in a cohort of paediatric patients with common ALL (n = 86) and preB‐ALL (n = 34) treated within the Co‐operative study group for childhood acute lymphoblastic leukaemia (CoALL) protocol, CoALL06‐97. Flow cytometric analysis showed that almost half of the patients expressed no or negligible amounts of p75NTR (<10%). The median expression in patients expressing p75NTR beyond that threshold was 49% (range 11–100%). In patients classified as low‐risk at diagnosis, p75NTR expression was significantly higher than in high‐risk patients (P = 0·001). Of note, p75NTR expression was lower in the 21 patients who subsequently developed relapse compared with those remaining in remission (P = 0·038). Accordingly, relapse‐free survival was significantly better in patients expressing high surface p75NTR (P = 0·041). Thus, in this prospective analysis, high p75NTR expression was a strong prognostic marker that identified a group of paediatric ALL patients with favourable outcome.</description><subject>Adolescent</subject><subject>B cell precursor‐acute lymphoblastic leukaemia</subject><subject>Biological and medical sciences</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>children</subject><subject>Female</subject><subject>Flow Cytometry</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Humans</subject><subject>Infant</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Leukocyte Count</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Neoplasm Proteins - blood</subject><subject>Nerve Tissue Proteins - blood</subject><subject>p75NTR</subject><subject>Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - blood</subject><subject>Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - therapy</subject><subject>Prognosis</subject><subject>Prospective Studies</subject><subject>Receptors, Nerve Growth Factor - blood</subject><subject>Survival Analysis</subject><subject>Treatment Outcome</subject><issn>0007-1048</issn><issn>1365-2141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkcFu1DAQhi0EokvhFZAvIDgk2HHi2AcOtAIWVIGEytlyvJNdL06c2km7e-MROPGAPAlOd6FH8MUjz_ePZ-ZHCFOS03RebXPKeJUVtKR5QUidEy6oyHf30OJv4j5akJTKKCnFCXoU45YQykhFH6ITWktKOOML9HNp1xvcQ7gGvA7-ZtzgVpvRBxzAwDAHL4a6-nT55SWG3RAgRut7bCPWCbz2U9CNAzwEv-59HK35I7c9HjSsrB5DejzDBpxLGJgpRB9-ff-hzTQCdvtu2PjG6Vutg-mbhs7qx-hBq12EJ8f7FH199_byfJldfH7_4fzNRWbKQohMMlMRYto0WFGIgkC9Ii0xtQAOACvezNuoayMbXRrJKl42UFZaS1MaQ5qGnaLnh7ppgKsJ4qg6G-dWdQ9-iooLxmQS_hMsSCXTfmUCxQE0wccYoFVDsJ0Oe0WJms1TWzV3pWaP1GyeujVP7ZL06fGPqelgdSc8upWAZ0dAR6NdG3RvbLzjJK04ZTRxrw_cjXWw_-8G1NnH5Ryx3-JJuJQ</recordid><startdate>200711</startdate><enddate>200711</enddate><creator>Troeger, Anja</creator><creator>Gudowius, Sonja</creator><creator>Escherich, Gabriele</creator><creator>Den Boer, Monique L.</creator><creator>Glouchkova, Ludmila</creator><creator>Ackermann, Birgit</creator><creator>Meisel, Roland</creator><creator>Laws, Hans‐Juergen</creator><creator>Groeger, Marketa</creator><creator>Wessalowski, Ruediger</creator><creator>Willers, Reinhart</creator><creator>Harbott, Jochen</creator><creator>Pieters, Rob</creator><creator>Goebel, Ulrich</creator><creator>Janka‐Schaub, Gritta E.</creator><creator>Hanenberg, Helmut</creator><creator>Dilloo, Dagmar</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>200711</creationdate><title>High nerve growth factor receptor (p75NTR) expression is a favourable prognostic factor in paediatric B cell precursor‐acute lymphoblastic leukaemia</title><author>Troeger, Anja ; Gudowius, Sonja ; Escherich, Gabriele ; Den Boer, Monique L. ; Glouchkova, Ludmila ; Ackermann, Birgit ; Meisel, Roland ; Laws, Hans‐Juergen ; Groeger, Marketa ; Wessalowski, Ruediger ; Willers, Reinhart ; Harbott, Jochen ; Pieters, Rob ; Goebel, Ulrich ; Janka‐Schaub, Gritta E. ; Hanenberg, Helmut ; Dilloo, Dagmar</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4288-93c500cf01322820e7d0f0c78e6eeed6b136577c9ba4c93564be45aa9c4cc0bb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adolescent</topic><topic>B cell precursor‐acute lymphoblastic leukaemia</topic><topic>Biological and medical sciences</topic><topic>Biomarkers, Tumor - metabolism</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>children</topic><topic>Female</topic><topic>Flow Cytometry</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Humans</topic><topic>Infant</topic><topic>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>Leukocyte Count</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Neoplasm Proteins - blood</topic><topic>Nerve Tissue Proteins - blood</topic><topic>p75NTR</topic><topic>Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - blood</topic><topic>Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - therapy</topic><topic>Prognosis</topic><topic>Prospective Studies</topic><topic>Receptors, Nerve Growth Factor - blood</topic><topic>Survival Analysis</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Troeger, Anja</creatorcontrib><creatorcontrib>Gudowius, Sonja</creatorcontrib><creatorcontrib>Escherich, Gabriele</creatorcontrib><creatorcontrib>Den Boer, Monique L.</creatorcontrib><creatorcontrib>Glouchkova, Ludmila</creatorcontrib><creatorcontrib>Ackermann, Birgit</creatorcontrib><creatorcontrib>Meisel, Roland</creatorcontrib><creatorcontrib>Laws, Hans‐Juergen</creatorcontrib><creatorcontrib>Groeger, Marketa</creatorcontrib><creatorcontrib>Wessalowski, Ruediger</creatorcontrib><creatorcontrib>Willers, Reinhart</creatorcontrib><creatorcontrib>Harbott, Jochen</creatorcontrib><creatorcontrib>Pieters, Rob</creatorcontrib><creatorcontrib>Goebel, Ulrich</creatorcontrib><creatorcontrib>Janka‐Schaub, Gritta E.</creatorcontrib><creatorcontrib>Hanenberg, Helmut</creatorcontrib><creatorcontrib>Dilloo, Dagmar</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of haematology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Troeger, Anja</au><au>Gudowius, Sonja</au><au>Escherich, Gabriele</au><au>Den Boer, Monique L.</au><au>Glouchkova, Ludmila</au><au>Ackermann, Birgit</au><au>Meisel, Roland</au><au>Laws, Hans‐Juergen</au><au>Groeger, Marketa</au><au>Wessalowski, Ruediger</au><au>Willers, Reinhart</au><au>Harbott, Jochen</au><au>Pieters, Rob</au><au>Goebel, Ulrich</au><au>Janka‐Schaub, Gritta E.</au><au>Hanenberg, Helmut</au><au>Dilloo, Dagmar</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>High nerve growth factor receptor (p75NTR) expression is a favourable prognostic factor in paediatric B cell precursor‐acute lymphoblastic leukaemia</atitle><jtitle>British journal of haematology</jtitle><addtitle>Br J Haematol</addtitle><date>2007-11</date><risdate>2007</risdate><volume>139</volume><issue>3</issue><spage>450</spage><epage>457</epage><pages>450-457</pages><issn>0007-1048</issn><eissn>1365-2141</eissn><coden>BJHEAL</coden><abstract>Summary
Nerve growth factor (NGF) plays a pivotal role in cellular survival/death decisions with the low affinity receptor p75NTR predominately transmitting anti‐proliferative signals. In spite of its established role in B‐cell function and identification as a prognostically favourable marker in a number of malignancies, little is known about the expression pattern and prognostic significance of p75NTR in B cell precursor‐acute lymphoblastic leukaemia (BCP‐ALL). p75NTR expression was prospectively studied on primary ALL‐blasts in a cohort of paediatric patients with common ALL (n = 86) and preB‐ALL (n = 34) treated within the Co‐operative study group for childhood acute lymphoblastic leukaemia (CoALL) protocol, CoALL06‐97. Flow cytometric analysis showed that almost half of the patients expressed no or negligible amounts of p75NTR (<10%). The median expression in patients expressing p75NTR beyond that threshold was 49% (range 11–100%). In patients classified as low‐risk at diagnosis, p75NTR expression was significantly higher than in high‐risk patients (P = 0·001). Of note, p75NTR expression was lower in the 21 patients who subsequently developed relapse compared with those remaining in remission (P = 0·038). Accordingly, relapse‐free survival was significantly better in patients expressing high surface p75NTR (P = 0·041). Thus, in this prospective analysis, high p75NTR expression was a strong prognostic marker that identified a group of paediatric ALL patients with favourable outcome.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>17910636</pmid><doi>10.1111/j.1365-2141.2007.06818.x</doi><tpages>8</tpages></addata></record> |
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| subjects | Adolescent B cell precursor‐acute lymphoblastic leukaemia Biological and medical sciences Biomarkers, Tumor - metabolism Child Child, Preschool children Female Flow Cytometry Hematologic and hematopoietic diseases Humans Infant Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Leukocyte Count Male Medical sciences Neoplasm Proteins - blood Nerve Tissue Proteins - blood p75NTR Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - blood Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - therapy Prognosis Prospective Studies Receptors, Nerve Growth Factor - blood Survival Analysis Treatment Outcome |
| title | High nerve growth factor receptor (p75NTR) expression is a favourable prognostic factor in paediatric B cell precursor‐acute lymphoblastic leukaemia |
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