Dll3 is expressed in developing hair cells in the mammalian cochlea
Notch mediates the process of lateral inhibition that controls the production of hair cells in the inner ear. Hair cells are known to express Notch ligands Dll1 and Jag2, which signal through Notch1 in adjacent supporting cells. However, recent genetic and pharmacological studies indicate that the l...
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| Veröffentlicht in: | Developmental dynamics 2007-10, Vol.236 (10), p.2875-2883 |
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| container_title | Developmental dynamics |
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| creator | Hartman, Byron H. Hayashi, Toshinori Nelson, Branden R. Bermingham‐McDonogh, Olivia Reh, Thomas A. |
| description | Notch mediates the process of lateral inhibition that controls the production of hair cells in the inner ear. Hair cells are known to express Notch ligands Dll1 and Jag2, which signal through Notch1 in adjacent supporting cells. However, recent genetic and pharmacological studies indicate that the level of Notch‐mediated lateral inhibition is greater than can be accounted for by Dll1 and Jag2. Here, we report that another Notch ligand, Dll3, is expressed in developing hair cells, in a pattern that overlaps that of Dll1 and Jag2. We analyzed the cochleae of Dll3pu mutant mice, but did not detect any abnormalities. However, earlier studies have demonstrated that there is functional redundancy among Notch ligands in cochlear development and loss of one ligand can be at least partially compensated for by another. Thus Dll3 may play a role in lateral inhibition similar to that of Dll1 and Jag2. Developmental Dynamics 236:2875–2883, 2007. © 2007 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/dvdy.21307 |
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Hair cells are known to express Notch ligands Dll1 and Jag2, which signal through Notch1 in adjacent supporting cells. However, recent genetic and pharmacological studies indicate that the level of Notch‐mediated lateral inhibition is greater than can be accounted for by Dll1 and Jag2. Here, we report that another Notch ligand, Dll3, is expressed in developing hair cells, in a pattern that overlaps that of Dll1 and Jag2. We analyzed the cochleae of Dll3pu mutant mice, but did not detect any abnormalities. However, earlier studies have demonstrated that there is functional redundancy among Notch ligands in cochlear development and loss of one ligand can be at least partially compensated for by another. Thus Dll3 may play a role in lateral inhibition similar to that of Dll1 and Jag2. 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Hair cells are known to express Notch ligands Dll1 and Jag2, which signal through Notch1 in adjacent supporting cells. However, recent genetic and pharmacological studies indicate that the level of Notch‐mediated lateral inhibition is greater than can be accounted for by Dll1 and Jag2. Here, we report that another Notch ligand, Dll3, is expressed in developing hair cells, in a pattern that overlaps that of Dll1 and Jag2. We analyzed the cochleae of Dll3pu mutant mice, but did not detect any abnormalities. However, earlier studies have demonstrated that there is functional redundancy among Notch ligands in cochlear development and loss of one ligand can be at least partially compensated for by another. Thus Dll3 may play a role in lateral inhibition similar to that of Dll1 and Jag2. Developmental Dynamics 236:2875–2883, 2007. © 2007 Wiley‐Liss, Inc.</description><subject>Animals</subject><subject>Cell Differentiation</subject><subject>cochlea</subject><subject>Dll1</subject><subject>Dll3</subject><subject>DSL ligands</subject><subject>hair cells</subject><subject>Hair Cells, Auditory - cytology</subject><subject>Hair Cells, Auditory - metabolism</subject><subject>Intercellular Signaling Peptides and Proteins - genetics</subject><subject>Intercellular Signaling Peptides and Proteins - metabolism</subject><subject>Intracellular Signaling Peptides and Proteins - genetics</subject><subject>Intracellular Signaling Peptides and Proteins - metabolism</subject><subject>Jag2</subject><subject>Jagged-2 Protein</subject><subject>Ligands</subject><subject>Math1</subject><subject>Membrane Proteins - genetics</subject><subject>Membrane Proteins - metabolism</subject><subject>Mice</subject><subject>Mice, Mutant Strains</subject><subject>Notch</subject><subject>organ of Corti</subject><subject>Receptors, Notch - genetics</subject><subject>Receptors, Notch - metabolism</subject><issn>1058-8388</issn><issn>1097-0177</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LwzAYgIMobk4v_gDJyYPQmY82SY-y-QWCFxU8hTR56yJpO5ttun9vawfe9JQX8vDwvg9Cp5RMKSHs0m3cdsooJ3IPjSnJZUKolPv9nKlEcaVG6CjGd0KIEik9RCMqFeM5F2M0m4fAsY8YvpYtxAgO-xo72EBolr5-wwvjW2whhNh_rBaAK1NVJnhTY9vYRQBzjA5KEyKc7N4Jer65fprdJQ-Pt_ezq4fEpoLIxBUFhUxJanIOpLRZoQriLFMgjBEUbOa4kYyWWZZalbPUdTcVtiy5EtZxySfofPAu2-ZjDXGlKx_71UwNzTpqoTiXecr-BRlJGcmF6MCLAbRtE2MLpV62vjLtVlOi-7a6b6t_2nbw2c66Lipwv-guZgfQAfj0AbZ_qPT8Zf46SL8B5ciDxg</recordid><startdate>200710</startdate><enddate>200710</enddate><creator>Hartman, Byron H.</creator><creator>Hayashi, Toshinori</creator><creator>Nelson, Branden R.</creator><creator>Bermingham‐McDonogh, Olivia</creator><creator>Reh, Thomas A.</creator><general>Wiley‐Liss, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>200710</creationdate><title>Dll3 is expressed in developing hair cells in the mammalian cochlea</title><author>Hartman, Byron H. ; Hayashi, Toshinori ; Nelson, Branden R. ; Bermingham‐McDonogh, Olivia ; Reh, Thomas A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4607-dbb1e5871a93e0fc5b8b0dc28e6aa61ec5d3a721f554c8924d213bcff386cd373</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Animals</topic><topic>Cell Differentiation</topic><topic>cochlea</topic><topic>Dll1</topic><topic>Dll3</topic><topic>DSL ligands</topic><topic>hair cells</topic><topic>Hair Cells, Auditory - cytology</topic><topic>Hair Cells, Auditory - metabolism</topic><topic>Intercellular Signaling Peptides and Proteins - genetics</topic><topic>Intercellular Signaling Peptides and Proteins - metabolism</topic><topic>Intracellular Signaling Peptides and Proteins - genetics</topic><topic>Intracellular Signaling Peptides and Proteins - metabolism</topic><topic>Jag2</topic><topic>Jagged-2 Protein</topic><topic>Ligands</topic><topic>Math1</topic><topic>Membrane Proteins - genetics</topic><topic>Membrane Proteins - metabolism</topic><topic>Mice</topic><topic>Mice, Mutant Strains</topic><topic>Notch</topic><topic>organ of Corti</topic><topic>Receptors, Notch - genetics</topic><topic>Receptors, Notch - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hartman, Byron H.</creatorcontrib><creatorcontrib>Hayashi, Toshinori</creatorcontrib><creatorcontrib>Nelson, Branden R.</creatorcontrib><creatorcontrib>Bermingham‐McDonogh, Olivia</creatorcontrib><creatorcontrib>Reh, Thomas A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Developmental dynamics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hartman, Byron H.</au><au>Hayashi, Toshinori</au><au>Nelson, Branden R.</au><au>Bermingham‐McDonogh, Olivia</au><au>Reh, Thomas A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dll3 is expressed in developing hair cells in the mammalian cochlea</atitle><jtitle>Developmental dynamics</jtitle><addtitle>Dev Dyn</addtitle><date>2007-10</date><risdate>2007</risdate><volume>236</volume><issue>10</issue><spage>2875</spage><epage>2883</epage><pages>2875-2883</pages><issn>1058-8388</issn><eissn>1097-0177</eissn><abstract>Notch mediates the process of lateral inhibition that controls the production of hair cells in the inner ear. Hair cells are known to express Notch ligands Dll1 and Jag2, which signal through Notch1 in adjacent supporting cells. However, recent genetic and pharmacological studies indicate that the level of Notch‐mediated lateral inhibition is greater than can be accounted for by Dll1 and Jag2. Here, we report that another Notch ligand, Dll3, is expressed in developing hair cells, in a pattern that overlaps that of Dll1 and Jag2. We analyzed the cochleae of Dll3pu mutant mice, but did not detect any abnormalities. However, earlier studies have demonstrated that there is functional redundancy among Notch ligands in cochlear development and loss of one ligand can be at least partially compensated for by another. Thus Dll3 may play a role in lateral inhibition similar to that of Dll1 and Jag2. 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| source | Wiley Online Library - AutoHoldings Journals; MEDLINE; Wiley Online Library Free Content; Alma/SFX Local Collection; EZB* |
| subjects | Animals Cell Differentiation cochlea Dll1 Dll3 DSL ligands hair cells Hair Cells, Auditory - cytology Hair Cells, Auditory - metabolism Intercellular Signaling Peptides and Proteins - genetics Intercellular Signaling Peptides and Proteins - metabolism Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism Jag2 Jagged-2 Protein Ligands Math1 Membrane Proteins - genetics Membrane Proteins - metabolism Mice Mice, Mutant Strains Notch organ of Corti Receptors, Notch - genetics Receptors, Notch - metabolism |
| title | Dll3 is expressed in developing hair cells in the mammalian cochlea |
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