Evaluation of a rapid strip and a particle agglutination tests for syphilis diagnosis
Abstract The availability of new diagnostic approaches, which are easier and faster to perform than conventional tests, offers the opportunity to improve the attention given to public health problems as syphilis. This study aimed to evaluate a rapid immunochromatographic strip test (Determine TP; Ab...
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Veröffentlicht in: | Diagnostic microbiology and infectious disease 2007-10, Vol.59 (2), p.123-126 |
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creator | Juárez-Figueroa, Luis Uribe-Salas, Felipe García-Cisneros, Santa Olamendi-Portugal, María Conde-Glez, Carlos J |
description | Abstract The availability of new diagnostic approaches, which are easier and faster to perform than conventional tests, offers the opportunity to improve the attention given to public health problems as syphilis. This study aimed to evaluate a rapid immunochromatographic strip test (Determine TP; Abbott Laboratories, Chicago, IL) and a nonequipment demanding particle microagglutination test (Serodia TP-PA; Fujirebio, Japan) for qualitative detection of treponemic antibodies. Sera from 548 women belonging to 3 population groups were tested; one of them showing low syphilis seroprevalence (1.5%) and the other 2 showing higher seroprevalences (>15%). By comparison with the gold standard (Venereal Disease Research Laboratories plus fluorescent treponemal antibody absorption), sensitivity and specificity values for both diagnostic tests were calculated. Sensitivity values of both tests evaluated were higher than 95% for 2 groups of 3 addressed; in one of the high syphilis prevalence groups, Serodia TP-PA showed 88.6% sensitivity. Specificity values were above 95% for all 3 groups. The use of simple/rapid treponemic tests as those included here may prove to be a suitable replacement for the traditional syphilis serology diagnosis approach, particularly at primary care settings. |
doi_str_mv | 10.1016/j.diagmicrobio.2007.04.008 |
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This study aimed to evaluate a rapid immunochromatographic strip test (Determine TP; Abbott Laboratories, Chicago, IL) and a nonequipment demanding particle microagglutination test (Serodia TP-PA; Fujirebio, Japan) for qualitative detection of treponemic antibodies. Sera from 548 women belonging to 3 population groups were tested; one of them showing low syphilis seroprevalence (1.5%) and the other 2 showing higher seroprevalences (>15%). By comparison with the gold standard (Venereal Disease Research Laboratories plus fluorescent treponemal antibody absorption), sensitivity and specificity values for both diagnostic tests were calculated. Sensitivity values of both tests evaluated were higher than 95% for 2 groups of 3 addressed; in one of the high syphilis prevalence groups, Serodia TP-PA showed 88.6% sensitivity. Specificity values were above 95% for all 3 groups. 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This study aimed to evaluate a rapid immunochromatographic strip test (Determine TP; Abbott Laboratories, Chicago, IL) and a nonequipment demanding particle microagglutination test (Serodia TP-PA; Fujirebio, Japan) for qualitative detection of treponemic antibodies. Sera from 548 women belonging to 3 population groups were tested; one of them showing low syphilis seroprevalence (1.5%) and the other 2 showing higher seroprevalences (>15%). By comparison with the gold standard (Venereal Disease Research Laboratories plus fluorescent treponemal antibody absorption), sensitivity and specificity values for both diagnostic tests were calculated. Sensitivity values of both tests evaluated were higher than 95% for 2 groups of 3 addressed; in one of the high syphilis prevalence groups, Serodia TP-PA showed 88.6% sensitivity. Specificity values were above 95% for all 3 groups. The use of simple/rapid treponemic tests as those included here may prove to be a suitable replacement for the traditional syphilis serology diagnosis approach, particularly at primary care settings.</description><subject>Agglutination Tests</subject><subject>Antibodies, Bacterial - blood</subject><subject>Bacterial diseases</subject><subject>Bacterial diseases of the genital system</subject><subject>Biological and medical sciences</subject><subject>Female</subject><subject>Fluorescent Treponemal Antibody-Absorption Test</subject><subject>Human bacterial diseases</subject><subject>Humans</subject><subject>Infectious Disease</subject><subject>Infectious diseases</subject><subject>Internal Medicine</subject><subject>Medical sciences</subject><subject>Primary care</subject><subject>Rapid diagnosis</subject><subject>Reagent Kits, Diagnostic</subject><subject>Reagent Strips</subject><subject>Sensitivity and Specificity</subject><subject>Syphilis</subject><subject>Syphilis - diagnosis</subject><subject>Syphilis - epidemiology</subject><subject>Syphilis Serodiagnosis</subject><subject>Time Factors</subject><subject>Treponema pallidum</subject><subject>Treponema pallidum - immunology</subject><issn>0732-8893</issn><issn>1879-0070</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNktuL1DAUh4so7rj6L0gR9K3jyaVN4oMg63qBBR90n0Oay3jGTlOTdmH-e1NnYMUXfQocvnPhy6-qXhDYEiDd6_3Wodkd0KbYY9xSALEFvgWQD6oNkUI1pQIPqw0IRhspFbuonuS8ByBUcXhcXRDRCi4k31S313dmWMyMcaxjqE2dzISuznPCqTajK5XJpBnt4Guz2w3LjOOJnn2ecx1iqvNx-o4D5no9a4wZ89PqUTBD9s_O72V1--H629Wn5ubLx89X724ayxWfm9ZQJbxjSgVvhHQqSGopp70LQGyw4Prg-p52jPtgZNsyJVXoeklbrizz7LJ6dZo7pfhzKQfpA2brh8GMPi5Zd5IxITr6T5CC5F33G3xzAovcnJMPekp4MOmoCejVvt7rP-3r1b4Grov90vz8vGXpD97dt551F-DlGTDZmiEkM1rM95wisgOuCvf-xPki7w590tmiH613mLydtYv4f_e8_WuMHXDEsvmHP_q8j0say_doojPVoL-ueVnjUtIDRAhgvwB39MAL</recordid><startdate>20071001</startdate><enddate>20071001</enddate><creator>Juárez-Figueroa, Luis</creator><creator>Uribe-Salas, Felipe</creator><creator>García-Cisneros, Santa</creator><creator>Olamendi-Portugal, María</creator><creator>Conde-Glez, Carlos J</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>20071001</creationdate><title>Evaluation of a rapid strip and a particle agglutination tests for syphilis diagnosis</title><author>Juárez-Figueroa, Luis ; 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This study aimed to evaluate a rapid immunochromatographic strip test (Determine TP; Abbott Laboratories, Chicago, IL) and a nonequipment demanding particle microagglutination test (Serodia TP-PA; Fujirebio, Japan) for qualitative detection of treponemic antibodies. Sera from 548 women belonging to 3 population groups were tested; one of them showing low syphilis seroprevalence (1.5%) and the other 2 showing higher seroprevalences (>15%). By comparison with the gold standard (Venereal Disease Research Laboratories plus fluorescent treponemal antibody absorption), sensitivity and specificity values for both diagnostic tests were calculated. Sensitivity values of both tests evaluated were higher than 95% for 2 groups of 3 addressed; in one of the high syphilis prevalence groups, Serodia TP-PA showed 88.6% sensitivity. Specificity values were above 95% for all 3 groups. 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subjects | Agglutination Tests Antibodies, Bacterial - blood Bacterial diseases Bacterial diseases of the genital system Biological and medical sciences Female Fluorescent Treponemal Antibody-Absorption Test Human bacterial diseases Humans Infectious Disease Infectious diseases Internal Medicine Medical sciences Primary care Rapid diagnosis Reagent Kits, Diagnostic Reagent Strips Sensitivity and Specificity Syphilis Syphilis - diagnosis Syphilis - epidemiology Syphilis Serodiagnosis Time Factors Treponema pallidum Treponema pallidum - immunology |
title | Evaluation of a rapid strip and a particle agglutination tests for syphilis diagnosis |
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