Evaluation of a rapid strip and a particle agglutination tests for syphilis diagnosis

Abstract The availability of new diagnostic approaches, which are easier and faster to perform than conventional tests, offers the opportunity to improve the attention given to public health problems as syphilis. This study aimed to evaluate a rapid immunochromatographic strip test (Determine TP; Ab...

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Veröffentlicht in:Diagnostic microbiology and infectious disease 2007-10, Vol.59 (2), p.123-126
Hauptverfasser: Juárez-Figueroa, Luis, Uribe-Salas, Felipe, García-Cisneros, Santa, Olamendi-Portugal, María, Conde-Glez, Carlos J
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container_end_page 126
container_issue 2
container_start_page 123
container_title Diagnostic microbiology and infectious disease
container_volume 59
creator Juárez-Figueroa, Luis
Uribe-Salas, Felipe
García-Cisneros, Santa
Olamendi-Portugal, María
Conde-Glez, Carlos J
description Abstract The availability of new diagnostic approaches, which are easier and faster to perform than conventional tests, offers the opportunity to improve the attention given to public health problems as syphilis. This study aimed to evaluate a rapid immunochromatographic strip test (Determine TP; Abbott Laboratories, Chicago, IL) and a nonequipment demanding particle microagglutination test (Serodia TP-PA; Fujirebio, Japan) for qualitative detection of treponemic antibodies. Sera from 548 women belonging to 3 population groups were tested; one of them showing low syphilis seroprevalence (1.5%) and the other 2 showing higher seroprevalences (>15%). By comparison with the gold standard (Venereal Disease Research Laboratories plus fluorescent treponemal antibody absorption), sensitivity and specificity values for both diagnostic tests were calculated. Sensitivity values of both tests evaluated were higher than 95% for 2 groups of 3 addressed; in one of the high syphilis prevalence groups, Serodia TP-PA showed 88.6% sensitivity. Specificity values were above 95% for all 3 groups. The use of simple/rapid treponemic tests as those included here may prove to be a suitable replacement for the traditional syphilis serology diagnosis approach, particularly at primary care settings.
doi_str_mv 10.1016/j.diagmicrobio.2007.04.008
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subjects Agglutination Tests
Antibodies, Bacterial - blood
Bacterial diseases
Bacterial diseases of the genital system
Biological and medical sciences
Female
Fluorescent Treponemal Antibody-Absorption Test
Human bacterial diseases
Humans
Infectious Disease
Infectious diseases
Internal Medicine
Medical sciences
Primary care
Rapid diagnosis
Reagent Kits, Diagnostic
Reagent Strips
Sensitivity and Specificity
Syphilis
Syphilis - diagnosis
Syphilis - epidemiology
Syphilis Serodiagnosis
Time Factors
Treponema pallidum
Treponema pallidum - immunology
title Evaluation of a rapid strip and a particle agglutination tests for syphilis diagnosis
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